Polymorphism
Matrix metalloproteinase 9 -1562C/T polymorphism increased protein levels in patients with colorectal cancer in a sample from southeastern Brazil
Authors: C.R. Hoelzle, K.C.S.F. Magalh�£es, S.S. Carvalho, G.A. Santos, I.M. Maia, M.C.P.S. Sousa, J.S. Andrade-Filho, G.M.G. Cruz and R.T. Sim�µes
We examined whether the allelic and/or genotypic profile of locus -1562C/T of the matrix metalloproteinase (MMP-9) gene influences the protein expression levels of MMP-9 in patients with colorectal cancer (CRC) compared with controls. A total of 104 patients with CRC and 84 controls were evaluated. Peripheral blood was collected from both groups and DNA e.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017478
- DOI:
- 10.4238/gmr.15017478
Association between ERCC5 gene polymorphisms and gastric cancer risk in a Chinese population
Authors: R.J. Li, M. Li, G.J. Liu, Y.W. Guo, H. Bai, P. Xiao and J.Z. Mei
We conducted a hospital-based case-control study to investigate the association between 3 common SNPs in the ERCC5 gene (rs1047768, rs751402, and rs17655) and the risk of developing gastric cancer. Between January 2013 and December 2014, samples were collected from 216 gastric cancer patients and 216 control subjects. ERCC5 rs1047768, rs751402, and rs1765.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017510
- DOI:
- 10.4238/gmr.15017510
Association of the interleukin-10 gene -1082A/G genetic polymorphism with risk of ischemic stroke in a Chinese population
Authors: W.Z. Li, C.Y. Gao, W.L. He and H.M. Zhang
We investigated the possible association between two single nucleotide polymorphisms of IL10 (-1082A/G and -592C/A) and susceptibility to ischemic stroke. In total, 335 patients with proven ischemic stroke and 335 control subjects were recruited from Xinxiang Central Hospital between March 2013 and May 2015. The IL10 -1082A/G and -529C/A polymorphisms wer.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017541
- DOI:
- 10.4238/gmr.15017541
Angiotensin-converting enzyme gene polymorphism (insertion/deletion) and liver fibrosis in Turkish patients from the western Black Sea region, Turkey
Authors: N.K. Turhan, S. Uygun Ilikhan, A.C. Hamamcioglu, Y. Ustundag, A. Dursun and F. Kokturk
Chronic viral hepatitis B, chronic viral hepatitis C, non-alcoholic steatohepatitis, alcoholic liver disease, autoimmune hepatitis, primary biliary cirrhosis, and secondary biliary cirrhosis are important health issues worldwide. While an association between angiotensin-converting enzyme gene insertion/deletion (ACE gene I/D) polymorphism and liver fibros.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.16.8
- DOI:
- 10.4238/2015.December.16.8
Association of the C677T polymorphism in the methylenetetrahydrofolate reductase gene with breast cancer in a Mexican population
Authors: A. Ramos-Silva,L.E. Figuera,O.M. Soto-Quintana,A.M. Puebla-PÃ?©rez,R. RamÃ?Ârez-PatiÃ?±o,I. GutiÃ?©rrez-Hurtado,D.I. Carrillo-Moreno, G.M. ZÃ?ºÃ?±iga-GonzÃ?¡lez,I.P. DÃ?¡valos-RodrÃ?Âguez and M.P. Gallegos-Arreola
The methylenetetrahydrofolate reductase (MTHFR) gene plays an important role in the steps involved in the processing of amino acids. The analysis of polymorphisms in the MTHFR gene has revealed associations with cancer; in particular the C677T polymorphism, which has been suggested to affect folate metabolism, DNA methylation, synthesis, and repair, and t.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.27.16
- DOI:
- http://dx.doi.org/10.4238/2015.April.27.16
MCP-1 gene polymorphisms in North Chinese patients with pulmonary tuberculosis
Authors: G.L. Shi,L. Yang,Y. Sun,Y.J. Yin and C.X. Song
Pulmonary tuberculosis (PTB) remains one of the most important infectious diseases worldwide. Several studies have suggested that genetic factors may affect the susceptibility to PTB, but the specific genes involved have not been fully characterized. The gene for monocyte chemoattractant protein 1 (MCP-1) has been linked to an increased risk of tuberculos.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.27.18
- DOI:
- http://dx.doi.org/10.4238/2015.April.27.18
Isolation and characterization of polymorphic microsatellite markers for blue fox (Alopex lagopus)
Authors: Y.M. Li, P.C. Guo, J.Y. Lu, C.Y. Bai, Z.H. Zhao and S.Q. Yan
The blue fox, belonging to the family Canidae, is a coat color variant of the native arctic fox (Alopex lagopus). To date, microsatellite loci in blue fox are typically amplified using canine simple sequence repeat primers. In the present study, we constructed an (AC)n enrichment library, and isolated and identified 17 polymor.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027990
- DOI:
- 10.4238/gmr.15027990
Study of the relationship between IL-10 polymorphism and serum lipoprotein levels in Han Chinese individuals
Authors: W.Q. Yang
Previous studies have shown that cytokines can affect serum lipoprotein concentrations. The aim of this study was to examine the association between IL-10 gene polymorphisms and serum lipoprotein levels of Han Chinese individuals. A total of 359 Han Chinese people were enrolled in this investigation. IL-10 -592, -819, and -108.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028016
- DOI:
- 10.4238/gmr.15028016
Single-nucleotide polymorphisms in dopamine receptor D1 are associated with heroin dependence but not impulsive behavior
Authors: J.H. Liu,H.J. Zhong,J. Dang,L. Peng and Y.S. Zhu
Previous studies suggested that dopamine receptors may be associated with drug dependence and impulsive behavior. In this study, we examined whether dopamine receptor D1 (DRD1) is associated with heroin dependence and the impulsive behavior in patients with heroin dependence. The participants included 367 patients with heroin dependence and 372 healthy co.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.27.19
- DOI:
- http://dx.doi.org/10.4238/2015.April.27.19
Association between NOS3 genetic variants and coronary artery disease in the Han population
Authors: G.L. Zhao, Q.J. Li and H.Y. Lu
The enzyme endothelial nitric oxide synthase (NOS3) is an important mediator of atherosclerotic disease and is associated with coronary artery disease (CAD). There is growing evidence that polymorphisms in NOS3 influence the progression of CAD; however, there is also a controversy regarding the association of polymorphisms in .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028044
- DOI:
- 10.4238/gmr.15028044