Polymorphism
Association between the PADI4 -94G/A polymorphism and rheumatoid arthritis: a meta-analysis in the Chinese population
Authors: H.X. Chang, B. Zhu, J.H. Yao, J. Wu, J. Wang and W. Sun
Although a number of studies have been conducted on the association between the peptidylarginine deiminase (PADI4) -94G/A polymorphism and rheumatoid arthritis (RA) in the Chinese population, the association remains elusive and controversial. To clarify the impact of the PADI4 -94G/A polymorphism on the risk of RA, a meta-analysis was performed in the Chi.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017391
- DOI:
- 10.4238/gmr.15017391
Correlations between the COMT gene rs4680 polymorphism and susceptibility to ovarian cancer
Authors: W. Pan and H. Liao
The objective of this study was to perform a systematic review of the correlations between the single nucleotide polymorphism rs4680 in the catechol-O-methyltransferase (COMT) gene and susceptibility to ovarian cancer. A computer search was carried out for relevant case-control studies published between January 2000 to January 2014 in databases such as Ov.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.14.8
- DOI:
- 10.4238/2015.December.14.8
Association of the interleukin-6 gene -572G/C polymorphism with cancer risk: a meta-analysis
Authors: Q. Zhao, B. Zhang, Y. Chen, M. Li, X. Zhao, H. Fan and S.M. Li
The -572G/C polymorphism in interleukin-6 (IL-6) gene is associated with the development of cancer. However, previous studies have shown conflicting results; therefore, the association must be verified by an appropriate meta-analysis. For this purpose, we performed a literature search of the PubMed database to identify all reports on association between t.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.14.20
- DOI:
- 10.4238/2015.December.14.20
Effect of GSTM1, GSTT1, and GSTP1 IIe105Val polymorphisms on susceptiblity to gestational diabetes mellitus
Authors: Y.H. Qiu, Y.L. Xu and W.H. Zhang
We investigate the role of the GSTM1, GSTT1, and GSTP1 IIe105Val genetic polymorphisms in the susceptibility to gestational diabetes mellitus. A total of 223 pregnant women with gestational diabetes mellitus and 265 healthy pregnant women were examined at The Second Affiliated Hospital of Shaanxi University of Chinese Medicine.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027711
- DOI:
- 10.4238/gmr.15027711
An SduI polymorphism at intron 20 of the Chinese Holstein cow STAT4 gene and its effect on milk performance traits
Authors: X.M. Song, L. Zhang, J.F. Jiang, F.X. Shi and Y.Q. Jiang
The signal transducer and activator of transcription (STAT) genes are responsive to a wide range of cytokines, growth factors, and hormones, and thus control important biological processes. In humans, STAT4 mutations have been identified as genetic markers for rheumatoid arthritis, systemic lupus erythematosus, and primary Sjögren’s syndrome, w.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.May.13.13
- DOI:
- 10.4238/2013.May.13.13
HuGE systematic review and meta-analysis demonstrate association of CASP-3 and CASP-7 genetic polymorphisms with cancer risk
Authors: S. Yan, Y.Z. Li, X.W. Zhu, C.L. Liu, P. Wang and Y.L. Liu
Genetic variations in the caspase genes CASP-3 and CASP-7 are known to be involved in apoptosis, cytokine maturation, cell growth and differentiation. Polymorphisms of CASP-3 and CASP-7 genes have been increasingly recognized as important regulators in the development of cancer. However, whether there is a specific association is still controversial. Ther.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.May.13.10
- DOI:
- 10.4238/2013.May.13.10
IL-17 rs2275913 genetic variation contributes to the development of gastric cancer in a Chinese population
Authors: B.L. Xu, Y.T. Li, S.X. Dong, J. Qi, H.M. Feng, L. Zi and D.Y. Yang
The purpose of this hospital-based case-control study was to assess whether the interleukin (IL)-17 rs2275913 genetic variation can influence susceptibility to gastric cancer. Samples from a total of 202 gastric cancer patients and 237 controls were collected from the Linyi People’s Hospital between March 2013 and March .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027756
- DOI:
- 10.4238/gmr.15027756
Ethnic variation of the C677T and A1298C polymorphisms in the methylenetetrahydrofolate-reductase (MTHFR) gene in southwestern Mexico.
Authors: V. Antonio-V�©jar, O. del Moral-Hern�¡ndez, L.C. Alarc�³n-Romero, E. Flores-Alfaro, M.A. Leyva-V�¡zquez, D. Hern�¡ndez-Sotelo and B. Illades-Aguiar
In this study, we examined the distribution of genotype and allele frequencies of the C677T and A1298C polymorphisms in the methylenetetrahydrofolate-reductase gene (MTHFR) in two ethnic groups in the State of Guerrero, Mexico, which were compared with those of the Mestizo population of the region. A comparative study was cond.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.29.8
- DOI:
- 10.4238/2014.September.29.8
Investigation of polymorphisms in anti-inflammatory cytokine genes in hematogenous osteomyelitis
Authors: A.E. Osman, M. Mubasher, N.E. ElSheikh, H. AlHarthi, I.A. AlAlallah, A.A. Elbeshir, M. Abashar, N. Elsidig, G. ElGhazali and A.-S.A. Fadil
Osteomyelitis is a progressive bone infection disease caused by destructive immunological inflammatory reactions following new bone formation. Anti-inflammatory cytokines are a series of immunoregulatory molecules that control the pro-inflammatory cytokine response. In this study, we investigated 9 single nucleotide polymorphisms in 5 different cytokine/c.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.15.4
- DOI:
- 10.4238/2015.December.15.4
Analysis of the polymorphisms XRCC1Arg194Trp and XRCC1Arg399Gln in gliomas
Authors: A.C. Cust�³dio, L.O. Almeida, G.R. Pinto, M.J. Santos, J.R.W. Almeida, C.A. Clara, J.A. Rey and C. Casartelli
XRCC genes (X-ray cross-complementing group) were discovered mainly for their roles in protecting mammalian cells against damage caused by ionizing radiation. Studies determined that these genes are important in the genetic stability of DNA. Although the loss of some of these genes does not necessarily confer high levels of se.. Read More»
- Genet. Mol. Res. 10(2):
- vol10-2gmr1125
- DOI:
- 10.4238/vol10-2gmr1125