Polymorphism
Predictive potential role of glutathione S-transferases polymorphisms in response to chemotherapy and breast cancer prognosis
Authors: P. Yuan, L. Yuan, B.L. Xu, C.Z. Wang, H.Z. Yang and Y. Li
The aim of this study was to evaluate the role of GSTM1 null/present, GSTT1 null/present, and GSTP1 polymorphisms in the clinical response to chemotherapy and treatment outcome of breast cancer. The GSTM1, GSTT1, and GSTP1 IIe105Val polymorphism genotypes were analyzed using polymerase chain reaction coupled with restriction fragment length polymorphism. .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.11.15
- DOI:
- 10.4238/2015.December.11.15
Updated analysis of studies on the cytotoxic T-lymphocyte-associated antigen-4 gene A49G polymorphism and Hashimoto�s thyroiditis risk
Authors: R. Ji, Y. Feng and W.W. Zhan
Published data on the association between the cytotoxic T-lymphocyte-associated antigen-4 gene A49G polymorphism and the risk for Hashimoto’s thyroiditis (HT) are inconclusive. A meta-analysis was performed to derive a more precise estimation. Published case-control studies in English or Chinese were identified. In total, 24 studies with 2295 cases .. Read More»
- Genet. Mol. Res. 12(2):
- 2013.April.26.4
- DOI:
- 10.4238/2013.April.26.4
CYP2C19 polymorphisms in acute coronary syndrome patients undergoing clopidogrel therapy in Zhengzhou population
Authors: Y.M. Guo, Z.C. Zhao, L. Zhang, H.Z. Li, Z. Li and H.L. Sun
The goal of this study was to explore the polymorphisms of CYP2C19 (CYP2C19*2, CYP2C19*3) in patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI) on clopidogrel therapy in Zhengzhou city for guidance on clinical medication and reduction in the incidence of thromboembolic events. Two h.. Read More»
- Genet. Mol. Res. 15(2):
Relationship between TBX20 gene polymorphism and congenital heart disease
Authors: X.F. Yang, Y.F. Zhang, C.F. Zhao, M.M. Liu, J.P. Si, Y.F. Fang,W.W. Xing and F.L. Wang
Congenital heart disease in children is a type of birth defect. Previous studies have suggested that the transcription factor, TBX20, is involved in the occurrence and development of congenital heart disease in children; however, the specific regulatory mechanisms are yet to be evaluated. Hence, this study aimed to evaluate th.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027374
- DOI:
- 10.4238/gmr.15027374
Meta-analysis of the association between the rs7903146 polymorphism at the TCF7L2 locus and type 2 diabetes mellitus susceptibility
Authors: X.H. Liu, C.G. Xie, Y. An, X.X. Zhang and W.B. Wu
Type 2 diabetes mellitus (T2DM) is a chronic disease caused by genetic and environmental factors. T2DM has been associated with specific polymorphisms in the TCF7L2 gene. This study evaluates the relationship between the rs7903146 locus polymorphism of the TCF7L2 gene and T2DM susceptibility through meta-analysis; the overall aim is to provide a basis for.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.14.12
- DOI:
- 10.4238/2015.December.14.12
Frequency of glutathione-S-transferase null-M1 and null-T1 genotypes among the Turabah population in Saudi Arabia
Authors: A.A. Mansour, O.M. Saleh, T. Askar, A.M. Salim and A. Mergani
Glutathione-S-transferases (GST) are key phase II detoxifying enzymes that play critical roles in protection against products of oxidative stress and against electrophiles. Glutathione S-transferase mu (GST-M1) and theta (GST-T1) are isoforms of glutathione transferase enzymes that participate in the metabolism of a wide range of chemicals. Deletion varia.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.14.13
- DOI:
- 10.4238/2015.December.14.13
Association of MMP3 genotype with susceptibility to frozen shoulder: a case-control study in a Chinese Han population
Authors: Q. Xu, P.Y. Gai, H.L. Lv, G.R. Li and X.Y. Liu
Genetic factors may play an important role in frozen shoulder etiology, which may involve matrix metalloproteinase-3 (MMP3) gene polymorphisms. In this study, we examined single nucleotide polymorphisms in MMP3 for their association with frozen shoulder susceptibility in a Chinese Han population. The rs591058, rs650108, and rs679620 polymorphisms in the M.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017228
- DOI:
- 10.4238/gmr.15017228
Association between the -607 C > A polymorphism in interleukin-18 gene promoter with gastrointestinal cancer risk: a meta-analysis
Authors: J. Yao, Z.H. Li, Y.X. Li, R. Zhang, D.G. Zhang, Z.L. Xu, L.S. Wang and J.Y. Wang
The interleukin-18 (IL-18) gene -607 C/A polymorphism has been reported to be associated with gastrointestinal cancer, but there are conflicting results from previous studies on said topic. Therefore, the aim of this meta-analysis is to derive a more precise estimation of the association between the -607 C/A polymorphism in the IL-18 gene and gastrointest.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.14.15
- DOI:
- 10.4238/2015.December.14.15
Role of ERCC2 and ERCC3 gene polymorphisms in the development of osteosarcoma
Authors: X. Ma, Y. Zhang, T.S. Sun and J.H. Yao
We conducted a case-control study to investigate the role of common SNPs in ERCC2 (rs13181 and rs1799793) and ERCC3 (rs4150441 and rs4150506) in the development of osteosarcoma. A 1:2 matched case-control study was conducted. Between January 2012 and December 2013, 141 patients with pathologically diagnosed osteosarcoma and 282 controls were recruited in .. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017302
- DOI:
- 10.4238/gmr.15017302
Association of a let-7 KRAS rs712 polymorphism with the risk of breast cancer
Authors: X. Huang, Y. Yang, Y. Guo, Z.L. Cao, Z.W. Cui, T.C. Hu and L.B. Gao
Breast cancer (BC) is a common malignancy affecting women, with increasing incidences of this disease in China every year. Recent studies have extensively investigated a single nucleotide polymorphism in the let-7 miRNA binding site of the 3'-untranslated region of KRAS mRNA. The aim of this study was to determine the genotype frequency of the KRAS rs712 .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.14.19
- DOI:
- 10.4238/2015.December.14.19