Polymorphism
First genetic linkage map for the mud crab (Scylla paramamosain) constructed using microsatellite and AFLP markers
Authors: H.Y. Ma, S.J. Li, N.N. Feng, C.Y. Ma, W. Wang, W. Chen and L.B. Ma
The mud crab (Scylla paramamosain) is of economic importance for the fisheries and aquaculture industry in China. In this study, we constructed the first genetic linkage map for this species using microsatellite and amplified fragment length polymorphism (AFLP) markers. The map consisted of 65 linkage groups, including 34 trip.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15026929
- DOI:
- 10.4238/gmr.15026929
Correlation between the genetic polymorphism of ORMDL3 gene and asthma risk:a meta-analysis
Authors: W.H. Zhai, C.Y. Song, Z.G. Huang and H. Sha
While increasing scientific evidence suggests that the ORMDL3 rs7216389 polymorphism may contribute to a higher susceptibility to asthma, many of the current studies have yielded inconclusive results. This meta-analysis aimed to assess the association between the ORMDL3 rs7216389 polymorphism and the risk of asthma. An extensive literature search for rele.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.29.3
- DOI:
- 10.4238/2015.June.29.3
Myoglobin A79G polymorphism association with exercise-induced skeletal muscle damage
Authors: T. Cui and M.S. Jiang
We assessed the role of A79G, a polymorphism of the myoglobin gene (MB), in susceptibility to exercise-induced skeletal muscle damage. Between January 2012 and December 2014, a total of 166 cases with exercise-induced skeletal muscle damage and 166 controls were recruited into our study. Genotyping of MB A79G was carried out u.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027506
- DOI:
- 10.4238/gmr.15027506
ERCC2 rs13181 polymorphism association with glioma susceptibility in a Chinese population
Authors: X. Gao, Y.J. Tang, G.F. Zhang, L. Yu and S.T. Qi
We conducted a case-control study to investigate the role of ERCC2 rs13181 polymorphism in glioma development. A total of 165 patients who were histopathologically diagnosed to have gliomas and 330 controls were collected at Jiujiang First People’s Hospital between July 2012 and June 2014. The ERCC2 rs13181 polymorphism .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027585
- DOI:
- 10.4238/gmr.15027585
Association of CYP1A1 MspI polymorphism with oral cancer risk in Asian populations: a meta-analysis
Authors: J.L. Xu, R. Xia, L. Sun, X. Min, Z.H. Sun, C. Liu, H. Zhang and Y.M. Zhu
Numerous studies regarding the association between the CYP1A1 MspI polymorphism and oral cancer risk in Asian populations have shown controversial results. To get a more precise estimation of this relationship, we conducted a comprehensive meta-analysis. PubMed, the Cochrane Library, Elsevier Science Direct, Web of Knowledge, .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027688
- DOI:
- 10.4238/gmr.15027688
The insertion/deletion polymorphism in the ACE gene and chronic obstructive pulmonary disease
Authors: S. Simsek, S. Tekes, D. Oral, A. Turkyilmaz, B. Isik, M.R. Isik and H. Akkoc
An insertion/deletion (I/D) polymorphism was identified in intron 16 of the gene encoding the human angiotensin I-converting enzyme (ACE), a candidate gene for chronic obstructive pulmonary disease (COPD). We investigated the relationship between this polymorphism in the ACE gene and the risk of developing COPD. Sixty-six COPD in-patients and 40 non-smoki.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.April.25.10
- DOI:
- 10.4238/2013.April.25.10
CTLA-4 and CD86 genetic variants and haplotypes in patients with rheumatoid arthritis in southeastern China
Authors: C.-P. Liu, J.-A. Jiang, T. Wang, X.-M. Liu, L. Gao, R.-R. Zhu, Y. Shen, M. Wu, T. Xu and X.-G. Zhang
The cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and costimulatory molecule (CD80/CD86) genes are important susceptibility genes associated with autoimmune diseases. CTLA-4 polymorphisms have been found to be associated with various autoimmune diseases. However, the association data are inconsistent for rheumatoid arthritis (RA). We investigated t.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.April.25.8
- DOI:
- 10.4238/2013.April.25.8
ERCC1 C118T polymorphism has predictive value for platinum-based chemotherapy in patients with late-stage bladder cancer
Authors: Z.C. Xu, H.Z. Cai, X. Li, W.Z. Xu, T. Xu, B. Yu, Q. Zou and L. Xu
This study aims to investigate the association between ERCC1 codon C118T polymorphism and the response rate of platinum-based chemotherapy in patients with late-stage bladder cancer. A total of 41 eligible patients histologically confirmed as having stage IV muscle-invasive transitional cell carcinoma of the bladder were treat.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027801
- DOI:
- 10.4238/gmr.15027801
Association of the rs7903146 and rs12255372 polymorphisms in the TCF7L2 gene with type 2 diabetes in a population from northeastern Brazil
Authors: C.M.A.R. Barros, A.P. Araujo-Neto, T.R. Lopes, M.A.L. Barros, F.J.N. Motta, R. Canalle, L.C.C. Nunes, J.A. Rey, R.R. Burbano, M.A. Lima-Barros, F.K.N. Yoshioka and G.R. Pinto
Approximately 200 million people suffer from type 2 diabetes (T2D) worldwide, and the rapid increase in the prevalence of this disease is likely a result of multiple environmental factors, such as increased food intake and decreased physical activity in genetically predisposed individuals. Different population studies have dem.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.29.1
- DOI:
- 10.4238/2014.September.29.1
Candidate genes for carcass traits in a tropical-adapted Brazilian composite beef breed
Authors: G. Veneroni-Gouveia, P.C. Tizioto, S.L.C. Meirelles, A.C. Santiago, M.M. Alencar and L.C.A. Regitano
Backfat thickness (BFT) and ribeye area (REA) are important production traits but, because they are measured late in the animal’s life, they have not been efficiently included in breeding programs. The aim of this study was to evaluate whether single nucleotide polymorphisms (SNPs) mapped to the leptin, PPARGC1A, PSMC1, CRH, and FABP4 genes, which i.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.11.14
- DOI:
- 10.4238/2015.December.11.14