Polymorphism
G�±q gene promoter polymorphisms and rheumatoid arthritis in the Han Chinese population are not associated
Authors: Y. Li, Y. Wang, Y. He, D. Wang, L. Deng, Y. Du and G. Shi
Mice that lose Gαq from their immune system can spontaneously develop inflammatory arthritis. Gαq expression in the peripheral blood lymphocytes of rheumatoid arthritis (RA) patients is significantly decreased in comparison to that in healthy individuals, and reduced Gαq expression is closely correlated with RA disease activity. These in.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.January.4.6
- DOI:
- 10.4238/2013.January.4.6
Meta-analysis of microsomal epoxide hydrolase gene polymorphism and the risk of breast carcinoma
Authors: J.H. Zhong,L.Q. Li,X.S. Mo,W.F. Gong,L. Ma,J. Chen and X.-M. You
Carcinogenesis of breast carcinoma is very complicated. Previous studies have suggested conflicting results regarding the association between Tyr113His and His139Arg microsomal epoxide hydrolase (mEH) gene polymorphisms and risk of breast carcinoma. We conducted a meta-analysis to examine the relationship between these polymorphisms and breast carcinoma r.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.27.28
- DOI:
- http://dx.doi.org/10.4238/2015.April.27.28
Estrogen receptor 1 PvuII and XbaI polymorphisms and susceptibility to Alzheimer�s disease: a meta-analysis
Authors: Y.H. Lee and G.G. Song
The aim of this study was to explore whether estrogen receptor 1 (ESR1) PvuII and XbaI polymorphisms are associated with susceptibility to Alzheimer’s disease (AD). We conducted a meta-analysis of the associations between AD and ESR1 PvuII and XbaI polymorphisms as well as haplotypes of the ESR1 PvuII and XbaI polymorphisms. A total of 1359 patients.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.10.17
- DOI:
- 10.4238/2015.August.10.17
Association between polymorphisms in the adiponectin gene (APM-1) and atherosclerotic cerebral infarction in a Hainan Chinese Han population
Authors: P. He, X.L.Chen and Y.P. Ding
We investigated the association between polymorphisms in the adiponectin gene (APM-1) and atherosclerotic cerebral infarction (ACI) in a Chinese Han population of Hainan Province. Polymerase chain reaction-restriction fragment length polymorphism and gene sequencing were used to analyze the distribution of APM-1 +45T/G and +276G/T genotypes and their alle.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.27.29
- DOI:
- http://dx.doi.org/10.4238/2015.April.27.29
Allelic polymorphism, gene duplication and balancing selection of the MHC class II DAB gene of Cynoglossus semilaevis (Cynoglossidae)
Authors: T.J. Xu*, Y.N. Sun* and R.X. Wang
Major histocompatibility complex (MHC) genes play an important role in the immune response of vertebrates. Allelic polymorphism and evolutionary mechanism of MHC genes have been investigated in many mammals, but much less is known in teleosts. We examined the polymorphism, gene duplication and balancing selection of the MHC cl.. Read More»
- Genet. Mol. Res. 10(1):
- vol10-1gmr960
- DOI:
- 10.4238/vol10-1gmr960
Investigation of polymorphisms in exon7 of the NSUN7 gene among Chinese Han men with asthenospermia
Authors: H.Y. Ren, R. Zhong, X.P. Ding, Z.Y. Chen and Y.L. Jing
Previous studies have shown that genetic polymorphisms in exon7 of the NSUN7 gene can be used as an infertility marker in Iranian men with asthenospermia. However, there have been no equivalent studies in China. In the present study, we investigated the possible association between the genetic polymorphisms in exon7 of NSUN7 and asthenospermia in a Chines.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.10.6
- DOI:
- 10.4238/2015.August.10.6
Association of methylenetetrahydrofolate reductase (MTHFR) gene polymorphism with ischemic stroke in the Eastern Chinese Han population
Authors: Q.-Q. Lv,J. Lu,H. Sun and J.-S. Zhang
The association between the MTHFR genetic polymorphism and ischemic stroke has been reported by a number of investigators. However, the results have been controversial and conflicting. The aim of this study was to explore the association between the MTHFR variants C677T and A1298C and the risk of ischemic stroke in an Eastern Chinese Han population. A tot.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.27.31
- DOI:
- http://dx.doi.org/10.4238/2015.April.27.31
Association of TIRAP (MAL) gene polymorhisms with susceptibility to tuberculosis in a Chinese population
Authors: Y.X. Zhang, Y. Xue, J.Y. Liu, M.Y. Zhao, F.J. Li, J.M. Zhou, H.J. Wang and J.C. Li
Toll-interleukin 1 receptor (TIR) domain containing adaptor protein (TIRAP; also known as MAL) is an essential adaptor molecule in Toll-like receptor signaling, involved in activating the innate immune response during infection. Genetic variations in the TIRAP gene may influence human susceptibility to infectious disease. To d.. Read More»
- Genet. Mol. Res. 10(1):
- vol10-1gmr980
- DOI:
- 10.4238/vol10-1gmr980
Analysis of polymorphisms in the FUT1 and TAP1 genes and their influence on immune performance in Pudong White pigs
Authors: Y. Zhang, M. Wang, X.Q. Yu, C.R. Ye and J.G. Zhu
FUT1 and TAP1 have been identified as candidate genes that offer resistance against Escherichia coli F18 infection, with the AA genotype in FUT1 and the GG genotype in TAP1 conferring resistance. In order to confirm polymorphisms at FUT1 M307 and TAP1 G729, and evaluate their influence on immunity performance in Pudong White pigs, we performed polymerase .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.16.19
- DOI:
- 10.4238/2015.December.16.19
Investigation of ABCB1 gene polymorphism with colchicine response in Beh�§etâ��s disease
Authors: H. Saricaoglu, M. Yilmaz, M. Karkucak, H.Z.Y. Ozturk, T. Yakut, T. Gulten, E.B. Baskan, K. Aydogan and K. Dilek
Colchicine is commonly used in the treatment of Behçet’s disease. However, some patients are unresponsive to colchicine treatment. Adenosine triphosphate-binding cassette subfamily B member 1 (ABCB1) transports colchicine out of cells. We investigated a possible association of C3435T polymorphism of the ABCB1 (MDR.. Read More»
- Genet. Mol. Res. 10(1):
- vol10-1gmr824
- DOI:
- 10.4238/vol10-1gmr824