Polymorphism
Genetic variability of DNA repair mechanisms in chemotherapy treatment outcome of gastric cancer patients
Authors: G. Zhong, H.K. Li, T. Shan and N. Zhang
We investigate whether three common polymorphisms in ERCC1 and ERCC2 are predictor factors for the chemotherapy response, as well as the clinic outcome of patients with gastric cancer. Between May 2011 and May 2013, 263 patients with gastric cancer who were newly diagnosed by histopathology were enrolled in our study. Genotyping of the ERCC1 rs11615 and r.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.16.22
- DOI:
- 10.4238/2015.December.16.22
Associations between HIF-1�± polymorphisms C1772T and G1790A and susceptibility to chronic obstructive pulmonary disease
Authors: W.T. Wei, B. Li, M. Chen, H.R. Jia and H.X. Zhang
In the present study, we examined whether hypoxia-inducible factor-1α (HIF-1α) polymorphisms are associated with the susceptibility to chronic obstructive pulmonary disease (COPD). One hundred and twenty patients with COPD and 112 healthy controls were recruited from the Han population in Southern China. Polymerase chain reaction-restriction f.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.21.2
- DOI:
- 10.4238/2015.December.21.2
Lack of association between potential prothrombotic genetic risk factors and arterial and venous thrombosis
Authors: F.C.G. Evangelista, D.R.A. Rios, D.D. Ribeiro, M.G. Carvalho, L.M.S. Dusse, A.P. Fernandes and A.P. Sabino
Recent studies have shown an association between thrombosis and factor VII (FVII), tissue factor (TF), and angiotensin-converting enzyme (ACE). This suggests that individuals with FVII-402 G/A, FVII-401 G/T, TF+5466 A/G, and ACE-287 insertion/deletion (I/D) polymorphisms present an increased risk of venous thrombosis, heart disease, and ischemic stroke co.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.14.21
- DOI:
- 10.4238/2015.August.14.21
Investigating paraoxonase-1 gene Q192R and L55M polymorphism in patients with renal cell cancer
Authors: O.A. Uyar, M. Kara, D. Erol, A. Ardicoglu and H. Yuce
Increased oxidative stress can help promote carcinogenesis, including development of renal cell carcinoma. The enzyme protects low-density lipoproteins from oxidation and can be a factor in this process. PON1 Q192R and L55M paraoxonase gene polymorphisms were assessed in 60 renal cell carcinoma patients and 60 healthy controls.. Read More»
- Genet. Mol. Res. 10(1):
- vol10-1gmr927
- DOI:
- 10.4238/vol10-1gmr927
Polymorphisms in the promoter regions of the CXCL1 and CXCL2 genes contribute to increased risk of alopecia areata in the Korean population
Authors: S.K. Kim, J-H. Chung, H.J. Park, S.W. Kang, D.-J. Lim, S.H. Byun, D.G. Baek, H.Y. Ko, B.-L. Lew, H.H. Baik and W.-Y. Sim
Alopecia areata (AA) is a common disease, which causes hair loss in humans. AA has a genetically complex inheritance. This study investigated the possible correlations between single nucleotide polymorphisms (SNPs) in the promoter regions of the chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) (CXCL1) and chemokine (C-X-C mot.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.14.29
- DOI:
- 10.4238/2015.August.14.29
Investigation into the association between NLRP3 gene polymorphisms and susceptibility to type 2 diabetes mellitus
Authors: S. Wang, F. Fang, W.B. Jin, X. Wang and X.S. Zheng
We conducted a case-control study to investigate the role of three common polymorphisms (rs10754558, rs7512998, and rs12137901) of the gene NLR family, pyrin domain containing 3 (NLRP3) in the development of type 2 diabetes mellitus (T2DM). Between May 2013 and May 2014, 385 patients with T2DM and 401 control subjects were enrolled in our study. Genotypin.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.21.15
- DOI:
- 10.4238/2015.December.21.15
Lack of association between ERCC5 gene polymorphisms and gastric cancer risk in a Chinese population
Authors: J.J. Lu, H.Q. Zhang, P. Mai, X. Ma, X. Chen, Y.X. Yang and L.P. Zhang
We conducted a case-control study to assess the association between single nucleotide polymorphisms in the ERCC5 promoter (rs2094258 and rs751402) and development of gastric cancer in a Chinese population. This investigation included 184 patients with pathologically diagnosed gastric cancer and 206 healthy subjects recruited b.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027779
- DOI:
- 10.4238/gmr.15027779
Association between PDCD1, CTLA4, and MECP2 gene polymorphisms and systemic lupus erythematosus in the Chinese Northern Han
Authors: H.R. Dong, H.S. Li, S.C. Wang, Q.M. Balin and P.Y. Chang
Systemic lupus erythematosus (SLE) is an autoimmune disease that results in chronic inflammation of different organ systems. Several susceptibility loci for SLE have been suggested in different populations, but the nature of the susceptibility genes has yet to be determined. The programmed cell death 1 gene (PDCD1), the cytotoxic T-lymphocyte-associated p.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.21.29
- DOI:
- 10.4238/2015.December.21.29
Association between polymorphisms in the interleukin-10 gene and risk of abdominal aortic aneurysm
Authors: F. Wang, Q.Q. Quan, C.L. Zhang, Y.B. Li and T.B. Jiang
In this case-control study, we attempted to investigate the role of three common single nucleotide polymorphisms (SNPs; -1082G/A rs1800896, -819T/C rs1800871, and -592A/C rs1800872) in the IL-10 gene in the development of abdominal aortic aneurysm in a Chinese population. Three hundred and eighty-one patients with abdominal aortic aneurysm and age- and ge.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.21.32
- DOI:
- 10.4238/2015.December.21.32
Isolation and characterization of novel polymorphic microsatellite loci in large yellow croaker (Larimichthys crocea)
Authors: X.Q. Wang, D. Zeng, X. Ma, G. Xiong, Z.Y. Wang and T. Sakamoto
The large yellow croaker (Larimichthys crocea) is one of the largest marine net-cage cultured species in the oceans around China. In the present study, we isolated and characterized 13 polymorphic microsatellite markers from genomic libraries of L. crocea. Loci were screened for 10 wild specimens from 2 sites in southeast of China. All loci were polymorph.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.14.7
- DOI:
- 10.4238/2015.August.14.7