Polymorphism
CXCL12 G801A polymorphism and susceptibility to glioma: a case�control study
Authors: S.F. Chang, S.L. Li, B. Yang, K.M. Yao, R.H. Miao, G.F. Liang and K.M. Zhang
Previous studies have demonstrated that the CXCL12 G801A polymorphism is closely correlated with tumor susceptibility. In addition, the CXCL12/CXCR4 pathway is closely related to proliferation, metastasis, and invasion of glioma. However, the genetic effects of the CXCL12 G801A polymorphism on glioma risk in Chinese populations remain unknown. In this stu.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.21.9
- DOI:
- 10.4238/2015.December.21.9
Association between XPG gene polymorphisms and development of gastric cancer risk in a Chinese population
Authors: Y.B. Feng, D.Q. Fan, J. Yu and Y.K. Bie
We conducted a case-control study to investigate the role of three common single nucleotide polymorphisms (SNPs) in the xeroderma pigmentosum complementation group G (XPG) gene (rs2094258, rs751402 and rs17655) in the development of gastric cancer in a Chinese population. Between January 2012 and December 2014, samples from a .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027877
- DOI:
- 10.4238/gmr.15027877
Association between IL-21 polymorphism and systemic lupus erythematosus: a meta-analysis
Authors: J.H. Qi, J. Qi, L.N. Xiang and G. Nie
Several case-control studies have been conducted to investigate the association between Interleukin-21 (IL-21) polymorphisms and systemic lupus erythematosus (SLE) susceptibility, and most of the studies focused on IL-21 rs907715 and rs2221903 polymorphisms. Given the inconsistent results from these studies, the present meta-analysis aimed to obtain a mor.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.14.22
- DOI:
- 10.4238/2015.August.14.22
Meta-analysis of the correlation between the TNF-�± 308G/A polymorphism and polycystic ovary syndrome
Authors: X.B. Liu, X.H. Deng, B. Zhou, L. Zhang and X.M. Niu
Previous studies have suggested that the tumor necrosis factor alpha (TNF-α) gene 308G/A polymorphism may be associated with polycystic ovary syndrome (PCOS) risk. However, this relationship is controversial. The present meta-analysis aimed to evaluate the correlation between the TNF-α308G/A polymorphism and suscep.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027923
- DOI:
- 10.4238/gmr.15027923
Association between single nucleotide polymorphisms of X-ray repair cross-complementing protein 4 gene and development of pancreatic cancer
Authors: Y. Ding and L.N. Li
We performed a study to evaluate X-ray repair cross-complementing protein 4 (XRCC4) gene polymorphisms and the development of pancreatic cancer. A case-control study including 206 patients with newly diagnosed primary pancreatic cancer and 412 controls was performed between January 2011 and October 2013 in a Chinese population. Genotypes of XRCC4 rs180537.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.14.25
- DOI:
- 10.4238/2015.August.14.25
Association between matrix metallopeptidase 1 and type 2 diabetes mellitus coexisting with coronary heart disease in a Han Chinese population
Authors: Y.Z. Ma, Q.Y. Jiang and D.Q. Kong
Matrix metallopeptidase 1 (MMP-1) has been reported to be involved in the coexistence of type 2 diabetes mellitus (T2DM) and coronary heart disease (CHD). We sought to examine the association between the MMP-1 gene polymorphism and coexistence of T2DM and CHD in a Han Chinese population. We extracted genomic DNA from the perip.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027938
- DOI:
- 10.4238/gmr.15027938
TNFR1-383 A��C polymorphism association with clinical manifestations in primary Sj�¶grenâ��s syndrome patients
Authors: A.L. Fletes-Rayas, C.A. Palafox-S�¡nchez, J.F. Mu�±oz-Valle,G. Orozco-Barocio, R.E. Navarro-Hern�¡ndez and E. Oregon-Romero
Primary Sjögren’s syndrome is an autoimmune disease affecting the function of exocrine glands. Tumor necrosis factor receptor-1 (TNFR1) is involved in apoptosis through extrinsic pathway initiation. The level of soluble TNFR1 is reported increased in rheumatoid arthritis, systemic lupus erythematosus, and primary Sj.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15024177
- DOI:
- 10.4238/gmr.15024177
Association of vitamin D receptor gene polymorphisms with end-stage renal disease and the development of high-turnover renal osteodystrophy in a Chinese population
Authors: L.Y. Wang, P. Zhang, H.F. Wang, Z.W. Qin, K.B. Wei and X.A. Lv
Two single nucleotide polymorphisms (SNPs; TaqI and ApaI) in the vitamin D receptor (VDR) gene have been identified as risk factors for the progression of end-stage renal disease (ESRD). The purpose of our study was to confirm the reported association of these two SNPs with ESRD risk and progression of renal osteodystrophy in .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15026825
- DOI:
- 10.4238/gmr.15026825
Glutathione S-transferase P1 rs1695 A>G polymorphism and breast cancer risk: evidence from a meta-analysis
Authors: M. Kuang, W. Xu, C.X. Cao, L.L. Shen, J. Chang, X.L. Zhang, J.F. Chen and C.J. Tang
Breast cancer (BC) is the most widespread cause of cancer-related deaths in women. Many published studies have assessed the association between the glutathione S-transferase P1 (GSTP1) rs1695 polymorphism and BC risk. However, the effect of the GSTP1 rs1695 polymorphism on BC risk has remained controversial. Therefore, this me.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027771
- DOI:
- 10.4238/gmr.15027771
Interleukin-6 (IL-6) -174G/C genomic polymorphism contribution to the risk of coronary artery disease in a Chinese population
Authors: L. Mao, G.Y. Geng, W.J. Han, M.H. Zhao, L. Wu and H.L. Liu
To investigate the role of IL-6 polymorphism (-174G/C and -572C/G) in the development of coronary artery disease (CAD), CAD patients (224) and control subjects (260) were recruited between January 2012 and December 2014. Genotyping at IL-6 -174G/C and -572C/G was conducted via polymerase chain reaction coupled to restriction f.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027803
- DOI:
- 10.4238/gmr.15027803