Polymorphism
Genetic polymorphisms of loci D18S53, D18S59, and D18S488 in fetuses from a Chinese Tianjin Han population
Authors: X.Z. Li, J. Liu, Y.F. Shi, D. Ju, Y. Zhang and T.F. Yue
We investigated the genetic polymorphisms of three short tandem repeat (STR) loci, D18S53, D18S59, and D18S488, on chromosome 18 in fetuses from a Chinese Tianjin Han population. Sixty-four villus samples and 374 amniotic fluid samples were collected from fetuses. Quantitative fluorescence polymerase chain reaction was perform.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027820
- DOI:
- 10.4238/gmr.15027820
Association between ERCC5 gene polymorphisms and gastric cancer risk
Authors: B.W. Guo, L. Yang, R. Zhao and S.Z. Hao
We investigate the role of ERCC5 gene polymorphisms (rs17655 and rs751402) in the development of gastric cancer in a Chinese population. A total of 142 gastric cancer patients whose diagnoses were confirmed by pathology, and 274 control subjects were recruited from Tangshan Gongren Hospital between March 2013 and March 2015. G.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027828
- DOI:
- 10.4238/gmr.15027828
Relationship between the G75A polymorphism in the apolipoprotein A1 (ApoA1) gene and the lipid regulatory effects of pravastatin in patients with hyperlipidemia
Authors: T.N. Liu, C.T. Wu, F. He, W. Yuan, S.X. Li, H.W. Li, H.Y. Yu and M. Wu
In this study, we investigated the relationship between the G75A polymorphism in the apolipoprotein A1 (ApoA1) gene and the lipid regulatory effect of pravastatin in patients with hyperlipidemia. A total of 179 patients were divided into two groups: the pravastatin (N = 97) and policosanol (N = 82) treatment groups. The total .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028216
- DOI:
- 10.4238/gmr.15028216
Association between XRCC1 Arg280His polymorphism and risk of hepatocellular carcinoma: a systematic review and meta-analysis
Authors: W. Xu, S. Liu, L. Li, Z.Y. Shen and Y.L. Wu
Hepatocellular carcinoma (HCC) is one of the most lifethreatening malignancies worldwide. Defects in DNA repair genes may increase the risk of HCC. X-ray cross-complementing group 1 gene (XRCC1) is a major DNA repair gene involved in base excision repair. Recently, several studies have indicated that an association exists between XRCC1 polymorphism and HC.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.29.5
- DOI:
- 10.4238/2015.June.29.5
Meta-analysis of correlation between the CYP1A2 -3860 G > A polymorphism and lung cancer risk
Authors: J. Ren, B.Z. He, T.S. Zhang, S.P. Lu and T. Yan
The aim of this meta-analysis was to assess the association between a polymorphism (-3860 G > A) in the cytochrome P450 1A2 (CYP1A2) gene and lung cancer susceptibility. Relevant studies were retrieved from the PubMed and EMBase databases, and additionally evaluated for conformance with the inclusion criteria. The odds rati.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028353
- DOI:
- 10.4238/gmr.15028353
Association between the C34T polymorphism of the AMPD1 gene and essential hypertension in Malaysian patients
Authors: R. Nemati, J. Lu, V. Ramachandran, A. Etemad, M. Heidari, M.J. Yahya, R. Roozafzoon and P. Ismail
The aim of this study was to determine whether C34T, a common polymorphism of the adenosine monophosphate deaminase 1 gene (AMPD1), is associated with essential hypertension (EH). We hypothesize that C34T is associated with the development of EH. A case-control design was used for this study. The DNA was extracted using a comm.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15026241
- DOI:
- 10.4238/gmr.15026241
Correlation between PPARg2 gene Pro12Ala polymorphism and cerebral infarction in an Inner Mongolian Han Chinese population
Authors: X. Li, B.L. Zhang*, X.G. Zhang and X.L. Su
The variant of PPAR-g2 has been shown to promote the increase of carotid IMT in patients suffering from cerebral infarction and the Pro12Ala polymorphism in the peroxisome proliferator-activated receptorg2 (PPARg2) gene may be associated with cerebral infarction. However, due to the different genetic background, race, and regi.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027332
- DOI:
- 10.4238/gmr.15027332
Differential gene expression in drought-tolerant sugarcane roots
Authors: J.S. Vantini, G.C. Dedemo, D.F. Jovino Gimenez, L.F.S. Fonseca, R.I.D. Tezza, M.A. Mutton, J.A. Ferro and M.I.T. Ferro
Drought is one of the most frequent abiotic stresses limiting the productivity and geographical distribution of sugarcane culture. The use of drought-tolerant genotypes is one approach for overcoming the effects of water stress. We conducted a comparative study to identify gene expression profiles under water stress in tolerant sugarcane roots. Two differ.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.29.13
- DOI:
- 10.4238/2015.June.29.13
Polymorphisms of GSTM1, GSTT1, and p53 in Goi�¢nia, Goi�¡s
Authors: D.A. Rodrigues, I.R. Costa, J.V.M. Martins, K.S.F. e Silva and K.K.V.O. Moura
Genetic polymorphisms are defined as changes within the DNA sequences of genes that have frequencies in the population higher than 1%. The glutathione S-transferases play an important role in the cellular detoxification systems involved in oxidative stress that can lead to accumulation of reactive oxygen species. Epidemiological studies have suggested tha.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.21.4
- DOI:
- 10.4238/2015.December.21.4
SNP at miR-483-5p-binding site in the 3'-untranslated region of the BSG gene is associated with susceptibility to esophageal cancer in a Chinese population
Authors: H.Y. Li, Y.C. Liu, Y.H. Bai, M. Sun, L. Wang, X.B. Zhang and B. Cai
The aim of this study was to investigate the association between a functional variant of the basigin (BSG) gene, caused by a polymorphism (rs11473) at the miR-483-5p binding site, and the risk of esophageal squamous cell carcinoma (ESCC) in the Chinese population. The rs11473 polymorphism was genotyped in 624 esophageal cancer.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027735
- DOI:
- 10.4238/gmr.15027735