Polymorphism
Influence of vascular endothelial growth factor and alpha-fetoprotein on hepatocellular carcinoma
Authors: E.Y. Yvamoto, R.F. Ferreira, V. Nogueira, M.A.S. Pinhel, G.D. Tenani, J.G.S.C. Andrade, M.E.L. Baitello, M.L. Greg�?³rio, P.S. Fucuta, R.F. Silva, D.R.S. Souza and R.C.M.A. Silva
We evaluated the influence of the vascular endothelial growth factor (VEGF) -C936T polymorphism on prognosis of hepatocellular carcinoma (HCC), cirrhosis, and hepatitis C virus (HCV) infection. Serum VEGF and alpha-fetoprotein (AFP) levels were determined and used to characterize sensitivity and specificity. A total of 285 subjects were studied: 68 HCC, 1.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.21.16
- DOI:
- 10.4238/2015.December.21.16
Genetic variability of ERCC1 and ERCC2 influences treatment outcomes in gastric cancer
Authors: W.H. Yu, Y.X. Wang, J.Q. Guo, Y.L. Wang, J.S. Zheng and K.X. Zhu
We performed a study to investigate the role of ERCC1 (rs11615, rs2298881, and rs3212986) and ERCC2 (rs13181, rs238406, and rs1799793) polymorphisms in the prognosis of gastric cancer. A total of 346 patients with gastric cancer were recruited between May 2009 and May 2012. Single nucleotide polymorphism genotyping was performed using the Sequenom MassARR.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.21.25
- DOI:
- 10.4238/2015.December.21.25
Association of regulator of G protein signaling (RGS5) gene variants and essential hypertension in Mongolian and Han populations
Authors: P.Y. Chang, L. Qin, P. Zhao and Z.Y. Liu
Genetic variants of the RGS5 gene are believed to be risk factors for hypertension and cardiovascular diseases. In this study, we investigated the association between RGS5 gene variants and hypertension in the Mongolian and Han populations. Peripheral blood was obtained from 429 unrelated Mongolian herdsmen and 416 Han farmers [including essential hyperte.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.21.37
- DOI:
- 10.4238/2015.December.21.37
Vascular endothelial growth factor +936C/T polymorphism and cancer risk in Asians: a meta-analysis
Authors: X.L. Liu, Q.F. Yang and B.H. Kong
Vascular endothelial growth factor (VEGF), the most important regulator of angiogenesis and vascular permeability, is involved in various steps of carcinogenesis. The +936C/T polymorphism of the VEGF gene has been reported to affect the VEGF protein level and to be related to the susceptibility of cancer. However, the results of published studies, as well.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.June.13.1
- DOI:
- 10.4238/2013.June.13.1
Isolation and characterization of 12 polymorphic microsatellite markers for the frog Pelophylax hubeiensis
Authors: J.-C. Yan, F.-H. Zhu and H.-L. Wu
Twelve polymorphic microsatellite loci were isolated from an (AC)n- and (AG)n-enriched DNA library for the endemic Chinese frog Pelophylax hubeiensis (Ranidae). The number of alleles per locus ranged from two to eight, with a mean of 5.17. The observed and expected heterozygosities ranged from 0.226 to 0.839 and from 0.204 to .. Read More»
- Genet. Mol. Res. 10(1):
- vol10-1gmr1003
- DOI:
- 10.4238/vol10-1gmr1003
Meta-analysis demonstrates lack of a relationship between XRCC1-399 gene polymorphisms and susceptibility to hepatocellular carcinoma
Authors: X.Y. Zeng, J.M. Huang, J.W. Xu, Y. Xu, H.P. Yu, L. Ji and X.Q. Qiu1,
XRCC1-399 allele polymorphisms have been reported to be associated with susceptibility to hepatocellular carcinoma (HCC), but the conclusions of the various studies have been inconsistent. We conducted a meta-analysis of available studies to determine whether XRCC1-399 alleles influence susceptibility to hepatocellular carcinoma. We searched English-langu.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.March.15.5
- DOI:
- 10.4238/2013.March.15.5
Polymorphisms of the angiotensin II type 1 receptor gene affect antihypertensive response to angiotensin receptor blockers in hypertensive Chinese
Authors: H.T. Gong, X.L. Ma, B.X. Chen, X.Y. Xu, Q. Li, C.X. Guo and F.H. Du
The renin-angiotensin-aldosterone system plays a key role in regulating blood pressure by maintaining vascular tone and the water/sodium balance. Many antihypertensive drugs target the renin-angiotensin-aldosterone system, but the effect differs considerably among hypertensive patients. We investigated whether genetic variants of the angiotensin II type 1.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.June.21.2
- DOI:
- 10.4238/2013.June.21.2
Association between ERCC1 and ERCC2 gene polymorphisms and susceptibility to pancreatic cancer
Authors: M.G. He, K. Zheng, D. Tan and Z.X. Wang
We conducted a study to investigate the association between ERCC1 (rs3212986) and ERCC2 (rs13181) gene polymorphisms and the risk of pancreatic cancer in a Chinese population. A total of 217 pancreatic cancer patients and 244 control subjects were recruited from the Nuclear Industry 215 Hospital of Shaanxi Province between February 2013 and December 2014... Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017879
- DOI:
- 10.4238/gmr.15017879
AGER genetic polymorphisms increase risks of breast and lung cancers
Authors: N.C. Yin, X.P. Lang, X.D. Wang and W. Liu
We evaluated the associations between three common polymorphisms in the AGER gene and the risks of breast (BC) and lung (LC) cancer using meta-analysis. A systematic electronic search of the literature was conducted to identify all potential correlation studies in Embase, Web of Science, Cochrane Library, CINAHL, PubMed, CISCOM, China BioMedicine (CBM), a.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.22.2
- DOI:
- 10.4238/2015.December.22.2
Lack of association between IL-10 -1082G/A polymorphism and chronic periodontal disease in adults
Authors: R. Hannum, F.R. Godoy , A.S. da Cruz, T.C. Vieira, L.B. Minasi, D. de M. e Silva, C.C. da Silva and A.D. da Cruz
Because of the complex interaction between periodontal pathogens and the host defense system, periodontitis is considered an inflammatory disorder of bacterial etiology that results in periodontal tissue damage. Genetic mechanisms may interfere with the gene expression of important inflammation mediators, modulating the immunologic response of an individu.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.22.7
- DOI:
- 10.4238/2015.December.22.7