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Animal Genetics   Research Article

Uncoupling Proteins and Cardiac Apoptosis in High Fat Diet-Fed Male Rats

Authors: K. Alsolami, Z. Alrefaie

This study aimed to assess impact of high fat diet (HFD) on cardiac apoptosis, and cardiac uncoupling proteins (UCPs) 2&3 expression. Twenty rats were fed either (45%) or (10%) fat diet for 6 months, then cardiac tissue expression of BAX, Bcl2, Fas, Fas-L (markers for apoptotic pathways) and UCP 2&3 were assessed. Results revealed enhancement of i.. Read More»

Genet. Mol. Res. 19(1):
Animal Genetics   Research Article

Protective effect of Vitamin D on Cardiac Mitochondrial Apoptotic pathway in Rats fed with high fat diet

Authors: Khadeejah Mesaid Al-Solami, Zienab Alrefaie, Hossam Awad

Background: Both diet quality and vitamin D status are important factors associated with many cardiovascular risk factors. Cardiac mitochondrial pathway of apoptosis has been associated with those factors. The current work aimed to assess the effect of chronic consumption of high fat diet (HFD) on the cardiac markers of mitochondrial path.. Read More»

Genet. Mol. Res. 19(5):
Animal Genetics   Research Article

Potential Protective Effect of Vitamin D on Cardiac Extrinsic pathways of apoptosis in Male Rats Fed with high fat diet

Authors: Khadeejah Mesaid Al-Solami, Zainab Al-refaie, Hossam Awad, Mahmood Rasool

Background: Obesity and vitamin D deficiency are increasing in Kingdom of Saudi Arabia (KSA) in last decades. Researchers have shown a relation between both disorders and cardiovascular disease (CVD). The present work aimed to investigate the possible protective effect of vitamin D on cardiac apoptosis in rats fed with a high fat diet. Methods: This study.. Read More»

Genet. Mol. Res. 18(1):
Human Genetics   Case Reports

Down-Klinefelter syndrome (48,XXY,+21) in a neonate associated with congenital heart disease

Authors: M.A. Rodrigues, L.F. Morgade, L.F.A. Dias, R.V. Moreira, P.D. Maia, A.F.H. Sales and P.D. Ribeiro

Double aneuploidy is considered a rare phenomenon. Herein, we describe a case of double aneuploidy 48,XXY,+21 in a neonate with congenital heart defects. The 28-day-old neonate male (23-year-old mother and 24-year-old father) was admitted to a neonatal intensive care unit owing to congenital heart disease. Echocardiography sho.. Read More»

Genet. Mol. Res. 16(3):
gmr16039780
DOI:
10.4238/gmr16039780
Human Genetics   Research Article

Pharmacogenetics-based warfarin dose prediction algorithm for patients with heart valve replacement in Southeast China

Authors: M.Q. Lin, J. Zhang, H.F. Qiu, X.B. Xie and H.T. Song

This study was designed to analyze the influence of polymorphisms in CYP2C9, VKORC1, CYP4F2, GGCX, and EPHX1 genes on the optimal warfarin dosage in patients who have undergone artificial heart valve replacement and establish an algorithm for use by physicians in Southeast China to predict each patient’s optimal steady-s.. Read More»

Genet. Mol. Res. 16(3):
gmr16038881
DOI:
10.4238/gmr16038881
Human Genetics   Research Article

Relationship between serum neopterin levels and coronary heart disease

Authors: Z.Y. Liu and Y.D. Li

The relationship between serum neopterin levels and coronary heart disease (CHD) was investigated. Eighty-six CHD patients were divided into an acute myocardial infarction (AMI) group (N = 21), an unstable angina pectoris (UAP) group (N = 35), and a stable angina pectoris (SAP) group (N = 30), based on coronary angiography (CAG), 30 subjects without CHD s.. Read More»

Genet. Mol. Res. 12(4):
2013.October.7.8
DOI:
10.4238/2013.October.7.8
Human Genetics   Research Article

Three-dimensional digital visible heart model and myocardial pathological characteristics of fetal single ventricle connected with aortic coarctation

Authors: B. Ren1*, Y. Jiang1*, H.M. Xia1, X.Y. Li1, L.W. Tan2, Y. Li2, Q.Y. Li2,X.S. Li2 and Y.H. Gao1

This study aimed to provide data for imaging diagnosis and clinical surgical plans by reconstructing a three-dimensional (3-D) digital visible heart model of single ventricle (SV) connection with aortic coarctation (CoA) and characterizing the myocardial and vascular wall pathological characteristics. Fifteen miscarried fetus cadavers with SV and CoA were.. Read More»

Genet. Mol. Res. 13(4):
2013.October.30.9
DOI:
10.4238/2013.October.30.9
Medical Genetics   Research Article

Genetic variants of the endothelial NO synthase gene (eNOS) may confer increased risk of sporadic congenital heart disease

Authors: K. Zhou, Y. Wang, W. Peng, J. Sun, Y.M. Qing and X.M. Mo

The endothelial NO synthase (eNOS) enzyme is expressed during the early stages of cardiogenesis and plays an important role in normal heart development. Genetic variations of eNOS G894T have been shown to influence individual susceptibility to some phenotypes of congenital heart disease (CHD) in different populations. We condu.. Read More»

Genet. Mol. Res. 13(2):
http://dx.doi.org/2014.May.16.4
DOI:
http://dx.doi.org/10.4238/2014.May.16.4
Human Genetics   Research Article

Relationship between the acylation-stimulating protein gene and coronary heart disease in the Xinjiang Uygur and Han populations of China

Authors: Y. Chen, Y.T. Ma, S.J. Yang, Y.N. Yang, Z.Y. Fu, X. Xie, X.M. Li and Y.Y. Zheng

The association of the single nucleotide polymorphism 301T>C in the coding region of the acylation-stimulating protein (ASP) gene with coronary heart disease (CHD) was investigated in the Uygur (385 CHD patients and 483 control subjects) and Han (390 CHD patients and 439 control subjects) populations of China. The frequency.. Read More»

Genet. Mol. Res. 13(2):
2014.April.8.6
DOI:
10.4238/2014.April.8.6
Human Genetics   Research Article

Transcriptome network analysis of potential candidate genes for heart failure

Authors: J. Chen, H.Y. Wang and C.Y. Zeng

The purpose of this study was to examine the hypothesis that a transcriptome network can be developed through a set of transcription factors regulated by the expression of various genes induced by dilated cardiomyopathy can be identified and modulated to respond to heart failure. We searched for significant pathways related to dilated cardiomyopathy using.. Read More»

Genet. Mol. Res. 12(4):
2013.October.18.7
DOI:
10.4238/2013.October.18.7

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