Gene
Association between STAT3 gene polymorphisms and ulcerative colitis susceptibility: a case-control study in the Chinese Han population
Authors: L. Wang, Z-T. Wang, H-X. Zhang, J. Liu, S-Y. Lu, R. Fan, J. Zhou, L. Xia, Y-W. Sun, J. Zhong, and Y-Z. Yuan
Ulcerative colitis (UC) is a chronic inflammation of the large intestine. The aim of this study was to investigate the association of two polymorphisms in STAT3 with the risk of UC development in the Chinese Han population. This is a hospital-based case-control study involving 56 UC patients and 274 controls. Genotyping was pe.. Read More»
- Genet. Mol. Res. 13(2):
- 2014.April.3.6
- DOI:
- 10.4238/2014.April.3.6
Association of paraoxonase polymorphisms with carotid artery atherosclerosis in essential hypertension patients
Authors: L. Han1,2, X.J. Xu1,2, X.H. Liang1,2 and J. Ma1,2
We investigated the relationships between paraoxonase genetic polymorphisms and essential hypertension in carotid artery atherosclerotic patients. The study included 353 Han participants and 240 Uighur participants from Xinjiang; they were further divided into two groups: essential hypertension with carotid artery atherosclerosis (CAAD group) and essentia.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.October.30.2
- DOI:
- 10.4238/2013.October.30.2
Association between the Rs3087243 polymorphism and risk for diabetes: a meta-analysis
Authors: J. Liu and H.-X. Zhang
The aim of this study was to evaluate the association between the rs3087243 polymorphism of the cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) gene and the risk of type 1 diabetes mellitus (T1D). A comprehensive meta-analysis of case-control studies was conducted to determine the association between the rs3087243 polymorphism (CT60A/G) and T1D and a.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.December.6.1
- DOI:
- 10.4238/2013.December.6.1
Predicting the target genes of microRNA based on microarray data
Authors: B. Cao, T. Ji, B. Zhou, J. Zou, G.Q. Jiao
MicroRNAs (miRNAs) are small non-coding RNAs of approximately 22 nucleotides in length, which play important roles in regulating gene expression post-transcriptionally. Several computational methods and algorithms have been developed to predict miRNA targets. In this study, we described a method that can be used to integrate m.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.December.2.4
- DOI:
- 10.4238/2013.December.2.4
Comparative genetic diversity of wild and hatchery-produced populations of tongue sole (Cynoglossus semilaevis) using multiplex PCR assays with polymorphic microsatellite markers
Authors: H.S. An, E.-M. Kim, H.W. Kang, H.S. Han, J.W. Lee, J.Y. Park,J.I. Myeong and C.M. An
The tongue sole, Cynoglossus semilaevis (Cynoglossidae), is one of the most economically important fishery resources in Korea. This study presents a preliminary investigation of the future viability of the complete aquaculture of tongue sole in Korea. Specifically, possible differences in genetic variability between wild populations of tongue sole from Ko.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.December.4.20
- DOI:
- 10.4238/2013.December.4.20
Myf5 gene polymorphisms and production performance traits in Songliao white geese
Authors: J.B. Wu, L.P. Cao, M.M. Li, N.N. Du, H.L. Huang and Y. Jin
To explore the relationship between Myf5 gene polymorphisms and production performance traits in Songliao white geese, we used the chicken Myf5 sequence to design primers and amplified part of the exon 1 sequence of the Songliao white goose Myf5 gene. Results of single-strand conformation polymorphism polymerase chain reaction.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.December.2.3
- DOI:
- 10.4238/2013.December.2.3
Insulin-like growth factor binding protein-3 (IGFBP-3) genetic variant and the risk of esophageal squamous cell carcinoma in a Chinese population
Authors: H.-P. Yang, J.-F. Liu, J. Rao, X.-M. Zhang, H.-L. Qian, X.-Q. Niu and Z.-L. Zhao
Insulin-like growth factor binding protein-3 (IGFBP-3) exerts anti-proliferative or pro-apoptotic effects through IGF-dependent as well as IGF-independent mechanisms in vitro. The purpose of this study was to examine the association between genetic variants in IGFBP-3 (rs2270628) and the risk of esophageal squamous cell carcin.. Read More»
- Genet. Mol. Res. 13(2):
- http://dx.doi.org/2014.May.30.10
- DOI:
- http://dx.doi.org/10.4238/2014.May.30.10
Sos recruitment system for the analysis of the interaction between sulfatase-modifying factor 2 subtypes and interleukin-13
Authors: W.Y. Zhang1*, H.Y. Liang1,2*, C. Yang1, L. Xue1 and X.F. Jiang1,2
(IL)-13 is a central mediator in allergic asthma. Our previous results have indicated that sulfatase-modifying factor 2 (SUMF2) interacts with IL-13 and inhibits its secretion. In this study, we investigated the interactions between SUMF2 subtypes and 2 types of IL-13. Wild type IL-13 (wh-IL-13) and its mutated counterpart (mh-IL-13) were analyzed and clo.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.November.18.15
- DOI:
- 10.4238/2013.November.18.15
A novel synthetic Cry1Ab gene resists rice insect pests
Authors: F.S. Song, D.H. Ni, H. Li, Y.B. Duan, Y.C. Yang, J.L. Ni, X.Z. Lu, P.C. Wei, L. Li and J.B. Yang
A few insect control genes of Bacillus thuringiensis have been modified successfully to increase the expression in plants by replacing rare codons, increasing GC content, and avoiding the DNA elements that could cause premature transcription termination, mRNA instability, and potential methylation. However, th.. Read More»
- Genet. Mol. Res. 13(2):
- 2014.April.3.12
- DOI:
- 10.4238/2014.April.3.12
Spectrum of mutations in the familial Mediterranean fever gene (MEFV) in Turkish patients of the Central Anatolia region: a comparison of two mutation detection system
Authors: A.G. Zamani, A. Acar and M.S. Yildirim
The purpose of this study was to determine the spectrum of the most common mutations in the familial Mediterranean fever gene (MEFV) in Turkish patients from the Central Anatolia region, by using two different methods for detecting FMF-associated mutations with different screening panels, and compare our results with other diagnostic molecular genetics ce.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.October.29.9
- DOI:
- 10.4238/2013.October.29.9