Gene
Co-transfection of adeno-associated virus-mediated human vascular endothelial growth factor165 and transforming growth factor-�²1 into annulus fibrosus cells of rabbit degenerative intervertebral discs
Authors: Y.M. Xi, Y.F. Dong, Z.J. Wang, Y. Liu, Z.Z. Diao and Y.G. Hu
Intervertebral disc degeneration is a common condition that may lead to low back pain and radiculopathy. Understanding the pathophysiology and cellular and molecular events of degenerative disc disease has resulted in the proposal of a gene therapy approach to halt and reverse disc degeneration. We explored the feasibility of reversing intervertebral disc.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.February.28.11
- DOI:
- 10.4238/2013.February.28.11
Mitochondrial and microsatellite DNA analyses showed comparative genetic diversity between parent and offspring populations of Korean black rockfish in a hatchery facility
Authors: H.S. An, J.W. Lee, J.Y. Park, J.I. Myeong and C.M. An
The black rockfish, Sebastes inermis (Sebastidae), is an important commercial fishery resource in Korea. As a preliminary investigation into the effect of artificial reproduction in a hatchery facility, the genetic divergence between parent and offspring populations of black rockfish was accessed using 10 polymorphic nuclear microsatellite DNA loci and a .. Read More»
- Genet. Mol. Res. 12(4):
- 2013.December.9.2
- DOI:
- 10.4238/2013.December.9.2
Interleukin-10 gene -592C>A polymorphism and susceptibility to gastric cancer
Authors: M. Qi, D.M. Liu, L.L. Pan and Y.X. Lin
Numerous studies have evaluated the association between the human interleukin-10 gene -592C>A polymorphism and gastric cancer risk. However, the results have been inconsistent. This meta-analysis was designed to resolve these controversies. Systematic searches of the electronic databases Embase, PubMed, and Google Scholar were performed to identify rel.. Read More»
- Genet. Mol. Res. 13(4):
Effects of genetic variants of CCR5 chemokine receptors on oral squamous cell carcinoma
Authors: C.R. Tanyel1, Z.B. Cincin2, B. Gokcen-Rohlig1, K. Bektas-Kayhan3, M. Unur3 and B. Cakmakoglu2
We aimed to evaluate the effect of genetic variants of the chemokine C-C motif receptor (CCR5) in the pathogenesis of oral squamous cell carcinoma (OSCC). A total of 127 patients diagnosed with OSCC and 104 healthy individuals were included in the study. The polymorphisms CCR5 59029 and CCR5-delta32 were assessed with the polymerase chain reaction-restric.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.November.18.20
- DOI:
- 10.4238/2013.November.18.20
Comparison of computed tomography and magnetic resonance imaging in the evaluation of facet tropism and facet arthrosis in degenerative cervical spondylolisthesis
Authors: C. Xu, Z.H. Ding and Y.K. Xu
The aim of this study was to determine the reliability of magnetic resonance imaging (MRI) in the assessment of facet tropism and facet arthrosis of spondylolisthesis levels in degenerative cervical spondylolisthesis as compared to computed tomography (CT). The discrepancies in the interpretation of CT and MRI data in the eval.. Read More»
- Genet. Mol. Res. 13(2):
- http://dx.doi.org/2014.May.30.5
- DOI:
- http://dx.doi.org/10.4238/2014.May.30.5
Association between CASP-8 gene polymorphisms and cancer risk in some Asian population based on a HuGE review and meta-analysis
Authors: Y.J. Zhang, X.P. Zhong, Y. Chen, S.R. Liu, G. Wu and Y.F. Liu
Genetic variation in the CASP-8 gene reportedly can increase cancer susceptibility by regulating tumor cell proliferation and apoptosis. Several studies have investigated this possibility; however, the conclusions remain controversial. We made a Human Genome Epidemiology (HuGE) review and did a meta-analysis to explore the association between CASP-8 gene .. Read More»
- Genet. Mol. Res. 12(4):
- 2013.February.28.3
- DOI:
- 10.4238/2013.February.28.3
Analysis of the genetic variability and structure of Ochlerotatus taeniorhynchus (Diptera: Culicidae) populations from the Colombian Atlantic coast on the basis of random amplified polymorphic DNA markers
Authors: F.J. Bello, N.A. Segura and M. Ruiz-Garcia
Ochlerotatus taeniorhynchus (Diptera: Culicidae) is a mosquito, which is an efficient vector of the virus causing epidemic-epizootic Venezuelan equine encephalitis in Colombia. This study used 9 random amplified polymorphic DNA (RAPD) markers to analyze the mosquito’s genetic variability and genetic structure of 122 spec.. Read More»
- Genet. Mol. Res. 13(2):
- http://dx.doi.org/2014.May.30.6
- DOI:
- http://dx.doi.org/10.4238/2014.May.30.6
Genetic diversity and relationships among accessions of five crested wheatgrass species (Poaceae: Agropyron) based on gliadin analysis
Authors: S.Y. Chen, X. Ma, X.Q. Zhang, L.K. Huang and J.N. Zhou
Agropyron Gaertn. is the most important genus in Triticeae (Poaceae), which includes many forage grasses with high economic value. The genetic diversity and relationships of 36 accessions from five crested wheatgrass species were analyzed by gliadin markers. A total of 54 product bands were detected after acid polyacrylamide gel electrophoresis (A-PAGE), .. Read More»
- Genet. Mol. Res. 12(4):
- 2013.November.18.19
- DOI:
- 10.4238/2013.November.18.19
Meta-analysis demonstrates lack of an association of microsomal epoxide hydrolase 1 polymorphisms with esophageal cancer risk
Authors: J.J. Hu1*, Z.T. Wang 2* and B. Li1
Epoxide hydrolases metabolize exogenous chemicals, including carcinogens such as polycyclic aromatic hydrocarbons. The relationship between microsomal epoxide hydrolase 1 (EPHX1) polymorphisms and esophageal cancer risk has been investigated in various ethnic populations, but the results have been contradictory. We investigated the association of EPHX1 Ty.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.October.15.2
- DOI:
- 10.4238/2013.October.15.2
Genetic diversity analysis of oriental river prawn, Macrobrachium nipponense, in Yellow River using microsatellite marker
Authors: H. Qiao1, D. Lv2, S.F. Jiang1, S.M. Sun1, Y.S. Gong1, Y.W. Xiong1, S.B. Jin1 and H.T. Fu1
To assess the genetic status of this species, the genetic diversity of wild Macrobrachium nipponense from seven geographic locations in the Yellow River basin were investigated using 20 polymorphic microsatellite DNA loci. The genetic diversity between populations was indicated by the mean number of alleles per locus and mean observed heterozygosity (H) a.. Read More»
- Genet. Mol. Res. 12(4):