Gene
Correlation between the 677C>T polymorphism in the methylene tetrahydrofolate reductase gene and serum homocysteine levels in coronary heart disease
Authors: Y.Y. Chen, B.N. Wang and X.P. Yu
The aim of the current study was to explore the correlation between serum homocysteine (HCY) levels and the methylene tetrahydrofolate reductase (MTHFR) gene 677C/T polymorphism and coronary heart disease (CHD). We consecutively enrolled 208 patients with CHD confirmed by CTA or coronary angiography from our hospital. An addit.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017238
- DOI:
- 10.4238/gmr.15017238
Conservation genetics of Annamocarya sinensis (Dode) Leroy, an endangered endemic species
Authors: Z.Y. Zhang, X.M. Pang, J.W. Han, Y. Wang and Y.Y. Li
The endangered perennial plant Annamocarya sinensis (Dode) Leroy is a tertiary relict tree restricted to southeastern China and northern Vietnam. To explore endangerment mechanisms, develop protection strategies, and guide reintroduction efforts for this species, we investigated genetic diversity and population structure by surveying 70 individuals from t.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.March.11.9
- DOI:
- 10.4238/2013.March.11.9
Association between survivin gene promoter -31G/C and -644C/T polymorphisms and non-small cell lung cancer
Authors: E. Aynaci, E. Coskunpinar, A. Eren, O. Kum, Y.M. Oltulu, N. Akkaya, A. Turna, I. Yaylim and P. Yildiz
Lung cancer is the most common cancer worldwide. Survivin is one of the first reported inhibitors of apoptosis proteins, which is an important family of proteins that regulate apoptosis. The survivin gene is located on human chromosome 17q25, which is composed of 142 amino acids. A common polymorphism of the survivin gene promoter -31G/C has been shown to.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.February.28.9
- DOI:
- 10.4238/2013.February.28.9
Influence of the 48867A>C (Asp358Ala) IL6R polymorphism on response to a lifestyle modification intervention in individuals with metabolic syndrome
Authors: V.R.A. Vargas, S.L. Bonatto, F.E. Macagnan, A.M.P. Feoli, C.S. Alho, N.D.V. Santos and V.M. Schmitt
We evaluated the response of individuals with metabolic syndrome to lifestyle modification intervention and examined the influence of the 48867A>C (Asp358Ala) IL6R (rs2228145) polymorphism on this response. Participants were randomly divided into two groups: NI, nutritional intervention; NIE, nutritional intervention and exercise practice. Intervention.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.February.28.8
- DOI:
- 10.4238/2013.February.28.8
A new method for estimating the number of non-differentially expressed genes
Authors: J. Wu, C.Y. Liu, W.T. Chen, W.Y. Ma and Y. Ding
Control of the false discovery rate is a statistical method that is widely used when identifying differentially expressed genes in high-throughput sequencing assays. It is often calculated using an adaptive linear step-up procedure in which the number of non-differentially expressed genes should be estimated accurately. In this paper, we discuss the estim.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017402
- DOI:
- 10.4238/gmr.15017402
Karyotype structure of Hypostomus cf. plecostomus (Linnaeus, 1758) from Tapaj�³s River basin, Southern Amazon: occurrence of sex chromosomes (ZZ/ZW) and their evolutionary implications
Authors: L.C. Oliveira, M.O. Ribeiro, E.S. Dutra, C.H. Zawadzki, A.L.B. Portela-Castro5 and I.C. Martins-Santos
Hypostomus is a group of fish with numerical and structural karyotypic variability. Among them, only six species, three of which belong to the Amazon basin, show a sex chromosome. In this study, we present the karyotype structure of Hypostomus cf. plecostomus from the Teles Pires river basin in the municipality of Alta Floresta, MT. The species has 2n = 6.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.18.5
- DOI:
- 10.4238/2015.June.18.5
Nucleolar-persistence phenomenon during spermatogenesis in genus Meccus (Hemiptera, Triatominae)
Authors: F.F. Madeira, A.A.C. Lima, J.A. Rosa, M.T.V. Azeredo-Oliveira and K.C.C. Alevi
The Triatominae subfamily consists of 150 species in 18 genera, grouped into six tribes. In cytogenetics, triatomines are important biological models because they have holocentric chromosomes and nucleolar persistence in meiosis. The phenomenon of nucleolar persistence has been described for 23 species of triatomine in three g.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017427
- DOI:
- 10.4238/gmr.15017427
Identification of a novel human testicular interstitial gene, RNF148, and its expression regulated by histone deacetylases
Authors: Y.Q. Liu, D.C. Tao, S.Y. Liao, Y. Yang, Y.X. Ma and S.Z. Zhang
Multiple genes are restrictively expressed in mammalian testicular tissues, and they play important roles in the complex process of spermatogenesis. Investigation of these genes and their expression regulation mechanisms is valuable to elucidate the molecular process of spermatogenesis. In this study, we identified a novel human gene, ring finger protein .. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.27.7
- DOI:
- 10.4238/2013.September.27.7
Improving plant transformation using Agrobacterium tumefaciens
Authors: L.V. Ribeiro Neto, A.P. Oliveira, M.V. Louren�§o, B.W. Bertoni, S.C. Fran�§a, T.M. Rosa-Santos and S.M. Zingaretti
Here, we report a quick and low-cost method to improve plant transformation using Agrobacterium tumefaciens. This method involves the use of physical wounding, ultrasound, and an increase in exposure time to the bacteria. We show how the transformation rate increased from 0 to 14% when an ultrasound pulse of 10 s was used in conjunction with 96 h of bacte.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.18.13
- DOI:
- 10.4238/2015.June.18.13
Association between FTO polymorphism in exon 3 with carcass and meat quality traits in crossbred ducks
Authors: W. Gan, Q. Song, N.N. Zhang, X.P. Xiong, D.M.C. Wang and L. Li
The fat mass and obesity-associated gene (FTO) is an excellent candidate gene that affects energy metabolism. Single nucleotide polymorphisms (SNPs) in FTO are associated with carcass and meat quality traits in pigs, cattle, and rabbits. The aim of this study was to investigate the association between novel SNPs in the FTO coding region and carcass and me.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.18.14
- DOI:
- 10.4238/2015.June.18.14