Gene
Analysis of FOS, BTG2, and NR4A in the function of renal medullary hypertension
Authors: Y.B. Wu, W.D. Zang, W.Z. Yao, Y. Luo, B. Hu, L. Wang and Y.L. Liang
The aim of this study was to identify differentially expressed genes (DEGs) in renal medullary hypertension and reveal their pathogenic mechanisms. We downloaded the gene expression profile of GSE28360 from the Gene Expression Omnibus database. The profile included 14 samples (5 normal and 9 hypertension). The DEGs in normal and disease samples were disti.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.19.4
- DOI:
- 10.4238/2013.September.19.4
Altered expression of CG5961, a putative Drosophila melanogaster homologue of FBXO9, provides a new model of Parkinson disease
Authors: E.M. Merzetti and B.E. Staveley
F-box proteins act as the protein recognition component of the Skp-Cul-F-box class of ubiquitin ligases. Two members of a gene sub-family encoding these proteins, FBXO7 and FBXO32, have been implicated in the onset and progression of degenerative disease. FBXO7 is responsible for rare genetic forms of Parkinson disease, while .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028579
- DOI:
- 10.4238/gmr.15028579
Molecular cloning and gene expression analysis of cystatin C-like proteins in spinyhead croaker Collichthys lucidus
Authors: W. Song, K.J. Jiang, F.Y. Zhang, M. Zhao and L.B. Ma
Cystatins are natural tight-binding reversible inhibitors of cysteine proteases. In this study, a cDNA library was constructed from Collichthys lucidus using the SMART technique. A complete cDNA sequence with high identity to the conserved sequence of the cystatin C gene was cloned from the library using EST analysis and rapid.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017417
- DOI:
- 10.4238/gmr.15017417
Polymorphisms of rs1799983 (G>T) and rs1800780 (A>G) of the eNOS gene associated with susceptibility to essential hypertension in the Chinese Hui ethnic population
Authors: B. Yang, J.R. Xu, X.M. Liu, Y. Yang, X.F. Na, M. Li and Y.J. Wang
We investigated a possible association of polymorphism of the eNOS gene and essential hypertension in the Chinese Hui population; polymorphisms of rs2070744 (T>C), rs1799983 (G>T), rs1800780 (A>G), and rs3918181 (A>G) loci of the eNOS gene were examined. We found that the genotypic frequencies at rs1799983 and rs1800780 loci differed significa.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.March.26.2
- DOI:
- 10.4238/2013.March.26.2
Relationship between the polymorphisms in KCNQ1 and type 2 diabetes in Chinese Kazakh population
Authors: L.J. Cui, X.Y. Chang, L.Y. Zhu, G. Feng, T. Zhou, C.X. Zhang, K.Y. Chong and K. Sun
Recently genome-wide association studies on East Asian populations reported an association between diabetes and several single nucleotide polymorphisms (SNPs) in a 40-kb linkage disequilibrium block in intron 15 of KCNQ1. However, the association between KCNQ1 variants and type 2 diabetes mellitus (T2DM) in Chinese Kazakh popu.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027503
- DOI:
- 10.4238/gmr.15027503
Impact of cold ischemia on cytokines after partial liver transplantation in rats
Authors: Q.-A. Qi, Z.-Y. Yang, K.-S. Ma, Q. Lu, S.-G. Wang, X.-W. Li, F. Xia, W. Liu and P. Bie
To study the impact of cold ischemia on tumor necrosis factor-alpha (TNF-α) and interleukin-10 (IL-10) expression after liver transplantation, a stable model of partial liver transplantation in rats was established. The experimental animals were divided into the following groups: a partial hepatectomy control group, a group that received partial liv.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.27.1
- DOI:
- 10.4238/2013.September.27.1
Initial assessment of natural diversity in Mexican fig landraces
Authors: M.T. Garc�?a-Ruiz, V.M. Mendoza-Castillo, E. Valadez-Moctezuma and A. Muratalla-L�?ºa
The common fig (Ficus carica L.) was introduced into Mexico by Spanish Franciscan missionaries in the 16th century. It is widely assumed that Mexican figs are the Spanish cultivar Black Mission. We collected and propagated 12 fig plants from six landraces from different states in Central Mexico that represent different climate. All of them were grown in a.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.23.12
- DOI:
- 10.4238/2013.September.23.12
Partial least squares-based gene expression analysis in preeclampsia
Authors: F. Jiang, Y. Yang, J. Li, W. Li, Y. Luo, Y. Li, H. Zhao, X. Wang, G. Yin and G. Wu
Preeclampsia is major cause of maternal and fetal morbidity and mortality. Currently, the etiology of preeclampsia is unclear. In this study, we investigated differences in gene expression between preeclampsia patients and controls using partial least squaresbased analysis, which is more suitable than routine analysis. Expression profile data were downloa.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.18.2
- DOI:
- 10.4238/2015.June.18.2
Positive evolution of the glycoprotein (GP) gene is related to transmission of the Ebola virus
Authors: Y.X. Jing, L.N. Wang, X.M. Wu and C.X. Song
Ebola hemorrhagic fever is a fatal disease caused by the negative-strand RNA of the Ebola virus. A high-intensity outbreak of this fever was reported in West Africa last year; however, there is currently no definitive treatment strategy available for this disease. In this study, we analyzed the molecular evolutionary history a.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017173
- DOI:
- 10.4238/gmr.15017173
Significantly association of diabetes mellitus with CTLA-4 gene polymorphisms based on a meta-analysis of epidemiological evidence in Asians and non-Asians
Authors: J. Liu, H.X. Zhang, G.Y. Feng and L. He
We evaluated association of polymorphisms in the CTLA-4 gene with the risk of type 1 diabetes mellitus. Comprehensive meta-analysis was applied to case-control studies of the association between CTLA-4 and type 1 diabetes mellitus to assess the joint evidence for the association, the influence of individual studies, and evidence for publication bias. We s.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.23.11
- DOI:
- 10.4238/2013.September.23.11