Gene
Molecular cloning and functional analysis of MRLC2 in Tianfu, Boer, and Chengdu Ma goats
Authors: H.G. Xu, G.Y. Xu, L. Wan and J. Ma
To determine the molecular basis of heterosis in goats, fluorescence quantitative polymerase chain reaction (PCR) was performed to investigate myosin-regulatory light chain 2 (MRLC2) gene expression in the longissimus dorsi muscle tissues of the Tianfu goat and its parents, the Boer and Chengdu Ma goats. The goat MRLC2 gene was differentially expressed in.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.March.15.7
- DOI:
- 10.4238/2013.March.15.7
Genetic diversity of gabiroba based on random amplified polymorphic DNA markers and morphological characteristics
Authors: E.S. de Assis, E.F. dos Reis, J.F.N. Pinto, L.A.S. Contim and L.A.S. Dias
The fragmentation of the original vegetation of the Cerrado biome, caused by the expansion of agricultural areas, mainly in central-west Brazil, calls for an assessment of the native population of this vegetation, especially of the species of interest for domestication and sustainable use. The purpose of this study was to characterize the genetic diversit.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.March.11.7
- DOI:
- 10.4238/2013.March.11.7
Roles of functional NFKB1 and �²-TrCP insertion/deletion polymorphisms in mRNA expression and epithelial ovarian cancer susceptibility
Authors: Z.H. Huo, H.J. Zhong, Y.S. Zhu, B. Xing and H. Tang
Epithelial ovarian cancer (EOC) is the leading cause of death among all gynecological cancers. Nuclear factor-kappa B (NF-κB) is involved in carcinogenesis and in the development of EOC. The β-transducin repeat-containing protein (β-TrCP) is a positive regulator of the NF-κB signaling pathway. Recent studies have indicated that the -.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.March.11.6
- DOI:
- 10.4238/2013.March.11.6
Spermiotaxonomy of the tribe Rhodniini (Hemiptera, Triatominae)
Authors: A. Ravazi, J. Oliveira, J.A. Rosa, M.T.V. Azeredo-Oliveira and K.C.C. Alevi
The tribe Rhodniini is a monophyletic group composed of 22 species, with 19 in the Rhodnius genus and three in the Psammolestes genus. These insects are morphologically very similar (cryptic species), and new tools are important for investigating the taxonomy of these vectors. Spermiotaxonomy is an important tool in differentiating between related species.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017366
- DOI:
- 10.4238/gmr.15017366
Lack of an effect of CYP3A4 and MDR1 gene polymorphisms on colchicine pharmacogenetics in the treatment of Familial Mediterranean fever
Authors: D. Dogruer, E. Tug, C. Bes and M. Soy
The P-gp/MDR1 multidrug transporter mediates detoxification of numerous drugs, including colchicine, and CYP3A4 is key to the biotransformation of colchicine. We investigated the effects of CYP3A4 and P-gp/MDR1 polymorphisms on bioavailability of colchicine in patients with Familial Mediterranean fever (FMF). Forty-eight Turkish patients with FMF treated .. Read More»
- Genet. Mol. Res. 12(3):
- 2013.January.24.2
- DOI:
- 10.4238/2013.January.24.2
Comparative and joint analyses of gene expression profiles under drought and rewatering in Arabidopsis
Authors: Z.H. Xu and W.R. Wu
Drought is a major limiting factor in crop production. Rewatering is a process opposite to drought, allowing plants to recover to their normal physiological state. To understand more thoroughly the set of genes involved in plant response to drought, we comparatively and jointly analyzed the microarray data of drought and rewatering experiments in Arabidop.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.13.6
- DOI:
- 10.4238/2013.September.13.6
Genetic determinants of the defense response of resistant and susceptible pepper (Capsicum annuum) cultivars infected with Phytophthora capsici (Oomycetes; Pythiaceae)
Authors: Y.-L. Zhang, D.-W. Li, Z.-H. Gong, J.-E. Wang, Y.-X. Yin and J.-J. Ji
Based on culture isolation and morphological observation blight-infected pepper plants in Shaanxi Province, China, we identified the pathogen causing pepper phytophthora blight as Phytophthora capsici. Varieties that differed in resistance (CM334, PBC602, and B27) were inoculated with this pathogen. The root activity of resistant CM334 variety was the hig.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.13.5
- DOI:
- 10.4238/2013.September.13.5
Molecular analysis of the SMN gene mutations in spinal muscular atrophy patients in China
Authors: W.L. Liu, F. Li, Z.X. He, R. Ai and H.W. Ma
Spinal muscular atrophy (SMA) is one of the most common autosomal recessive diseases. Survival motor neuron1 (SMN1) is the SMA disease-determining gene. We examined the molecular basis of SMA in 113 Chinese SMA patients. Homozygous exon 7 and 8 deletions in SMN1 were detected by PCR-RFLP. Heterozygous deletion of SMN1 was analyzed based on variation of th.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.13.4
- DOI:
- 10.4238/2013.September.13.4
Characterization and molecular mapping of a dwarf mutant in wheat
Authors: X.J. Jin, D.F. Sun, H.Y. Li, Y. Yang and G.L. Sun
A spontaneous dwarf mutant of wheat was found in an F5 generation line derived from a cross between Huamai No. 9 and Een No. 1 in 1998; it was named Huaai 01. We characterized the genetic pattern of Huaai 01 and mapped the gene controlling the dwarf trait. This dwarf mutant was found insensitive to exogenous gibberellic acid treatment, based on the length.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.12.2
- DOI:
- 10.4238/2013.September.12.2
Mitochondrial and nuclear genes as the cause of complex I deficiency
Authors: A.R. Rezaee, A. Azadi, M. Houshmand, F. Mahmoodi, Z. Purpak, S. Safaei, P. Karimi, M. Ghabaee and M.A. Sahraian
Multiple sclerosis (MS) is an immunological inflammatory disease of the central nervous system. The pathogenesis of MS is incompletely understood, but various studies have suggested that mitochondrial dysfunction is associated with the disease. Mitochondria are among the main cellular sources of reactive oxygen and nitrogen species, and they play a pivota.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.12.1
- DOI:
- 10.4238/2013.September.12.1