Gene
Use of a synthetic lethal screen to identify genes related to TIF51A in Saccharomyces cerevisiae
Authors: Frigieri MC, Thompson GM, Pandolfi JR, Zanelli CF and Valentini SR
The putative eukaryotic translation initiation factor 5A (eIF5A) is an essential protein for cell viability and the only cellular protein known to contain the unusual amino acid residue hypusine. eIF5A has been implicated in translation initiation, cell proliferation, nucleocytoplasmic transport, mRNA decay, and actin polariza.. Read More»
- Genet. Mol. Res. 6(1):
Translocation breakpoints of chromosome 1 in male carriers: clinical features and implications for genetic counseling
Authors: R.X. Wang, H.G. Zhang, Y. Pan, S. Chen, F.G. Yue, D.L. Zhu and R.Z. Liu
Reciprocal translocation is closely associated with male infertility and recurrent miscarriages. Balanced reciprocal translocations associated with reproductive failures are predominantly observed on chromosome 1. Additionally, infertile male patients present a number of breakpoints throughout chromosome 1. A translocation bre.. Read More»
- Genet. Mol. Res. 15(4):
- gmr.15048707
- DOI:
- 10.4238/gmr.15048707
Polyploidy and epigenetic events in the evolution of Anura
Authors: M.L. Be?§ak
This article reviews the polyploidy events that have long been demonstrated to play a role in the evolution of Anura, while also discussing the importance of epigenetic control of gene expression and diversity. Findings on Brazilian autopolyploid anurans, mainly of the genus Odontophrynus, obtained in previous studies.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.August.7.15
- DOI:
- 10.4238/2014.August.7.15
Personalized diagnosis by cached solutions with hypertension as a study model
Authors: P.C. Carvalho, S.S. Freitas, A.B. Lima, M. Barros, I. Bittencourt, W. Degrave, I. Cordovil, R. Fonseca, M.G.C. Carvalho, R.S. Moura Neto and P.H. Cabello
Statistical modeling of links between genetic profiles with environmental and clinical data to aid in medical diagnosis is a challenge. Here, we present a computational approach for rapidly selecting important clinical data to assist in medical decisions based on personalized genetic profiles. What could take hours or days of .. Read More»
- Genet. Mol. Res. 5(4):
Isolation and characterization of NBS-LRR- resistance gene candidates in turmeric (Curcuma longa cv. surama)
Authors: R.K. Joshi, S. Mohanty, E. Subudhi and S. Nayak
Turmeric (Curcuma longa), an important asexually reproducing spice crop of the family Zingiberaceae is highly susceptible to bacterial and fungal pathogens. The identification of resistance gene analogs holds great promise for development of resistant turmeric cultivars. Degenerate primers designed based on known resistance ge.. Read More»
- Genet. Mol. Res. 9(3):
- vol9-3gmr910
- DOI:
- 10.4238/vol9-3gmr910
Molecular thrombophilic profile in Mexican patients with idiopathic recurrent pregnancy loss
Authors: J.J. L?³pez-Jim?©nez, ?. Porras-Dorantes, C.I. Ju?¡rez-V?¡zquez,J.E. Garc?a-Ortiz, C.A. Fuentes-Ch?¡vez, I.J. Lara-Navarro and A.R. Jaloma-Cruz
Idiopathic recurrent pregnancy loss (IRPL) is defined by three or more consecutive miscarriages occurring before the twentieth week of gestation as a result of unidentified etiological factors. The results of previous studies have indicated that prothrombotic factors play a pathogenic role in early and late pregnancy. This stu.. Read More»
- Genet. Mol. Res. 15(4):
- gmr.15048728
- DOI:
- 10.4238/gmr.15048728
Temporal genetic differentiation in cultured and natural beds of the brown mussel Perna perna (Mytilidae)
Authors: Appio KT and Weber LI
Perna perna is the most important cultivated mussel of Santa Catarina, Brazil, sustaining an important economic input for many local families. Natural stocks of P. perna are depleted by the extraction of adults and seeds for consumption and culture. The aim of the present study was to use the microsatellite locus pms-2 to stud.. Read More»
- Genet. Mol. Res. 6(1):
Identification of floral genes for sex determination in Calamus palustris Griff. by using suppression subtractive hybridization
Authors: C.Y. Ng, R. Wickneswari and C.Y. Choong
Calamus palustris Griff. is an economically important dioecious rattan species in Southeast Asia. However, dioecy and onset of flowering at 3-4 years old render uncertainties in desired female:male seedling ratios to establish a productive seed orchard for this rattan species. We constructed a subtractive library for .. Read More»
- Genet. Mol. Res. 13(3):
- 2014.August.7.18
- DOI:
- 10.4238/2014.August.7.18
Evaluation of hot saline solution and restriction endonuclease techniques in cytogenetic studies of Cycloneda sanguinea L. (Coccinellidae)
Authors: Maffei EMD and Pompolo SG
The goal of the present study was to determine if simple methods, especially hot saline solution (HSS) and MspI and HaeIII restriction endonucleases, which do not require special equipments, may be helpful in studies of genetic variability in the lady beetle, Cycloneda sanguinea. The HSS method extracted the heterochromatin re.. Read More»
- Genet. Mol. Res. 6(1):
Splice site prediction using stochastic regular grammars
Authors: Kashiwabara AY, Vieira DCG, Machado-Lima A and Durham AM
This paper presents a novel approach to the problem of splice site prediction, by applying stochastic grammar inference. We used four grammar inference algorithms to infer 1465 grammars, and used 10-fold cross-validation to select the best grammar for each algorithm. The corresponding grammars were embedded into a classifier a.. Read More»
- Genet. Mol. Res. 6(1):