Cancer
Well-balanced commensal microbiota contributes to anti-cancer response in a lung cancer mouse model
Authors: Q.-F. Gui, H.-F. Lu, C.-X. Zhang, Z.-R. Xu and Y.-M. Yang
The intestinal microflora affects inflammation and immunity, not only locally at the mucosal level but also systemically, raising the question of whether the microflora affects inflammatory processes that contribute to cancer and its therapy. Prebiotics have also been found to play an antitumor role that is not limited to the gut. We investigated the anti.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.25.16
- DOI:
- 10.4238/2015.May.25.16
Inhibitor of signal transducer and activator of transcription 3 (STAT3) suppresses ovarian cancer growth, migration and invasion and enhances the effect of cisplatin in vitro
Authors: Y.J. Tang, Z.L. Sun, W.G. Wu, J. Xing, Y.F. He, D.M. Xin and P. Han
The aim of the present study was to investigate the anti-ovarian cancer effect of the inhibitor of signal transducer and activator of transcription 3 (STAT3), WP1066. Western blot was used to detect the phosphorylation of STAT3 in ovarian cancer cell line SKOV3 and cisplatin-resistant ovarian cancer cell line SKOV3/DDP. MTT and colony-forming assays were .. Read More»
- Genet. Mol. Res. 14(1):
- http://dx.doi.org/2015.March.30.3
- DOI:
- http://dx.doi.org/10.4238/2015.March.30.3
Gly71Arg UGT1A1 polymorphism is associated with breast cancer susceptibility in Han Chinese women
Authors: J. Shi, L.H. Li, X.Y. Duan, Q. Liu, L.L. Sun and Y.T. Tian
Breast cancer is among the most common causes of cancer-related death in women worldwide. Previous studies have demonstrated an association between prolonged estrogen exposure and increased risk of breast cancer. Uridine 5'-diphospho-glucuronosyltransferase 1-1 (UGT1A1) plays a significant role in the detoxification of estrogens. Two major genetic polymor.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038332
- DOI:
- 10.4238/gmr.15038332
cDNA cloning, characterization, and pharmacologic evaluation of anticancer activity of a lectin gene in Pinellia integrifolia
Authors: L.L. Liu, Z.J. Yang and Z.S. Peng
Plant lectins are proteins that possess at least one non-catalytic domain, which could reversibly bind to specific monosaccharides or oligosaccharides. The important roles played by plant lectins in immune regulation, signaling pathways, and plant defense could be attributed to their specific binding activities with carbohydrates. In this study, a Pinelli.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038516
- DOI:
- 10.4238/gmr.15038516
Pharmacogenetic role of XRCC1 polymorphisms on the clinical outcome of gastric cancer patients with platinum-based chemotherapy: a systematic review and meta-analysis
Authors: J. Xu, J. Ma, H.T. Zong, S.Y. Wang and J.W. Zhou
It is still controversial whether X-ray repair cross-complementing group (XRCC1) gene polymorphisms (Arg194Trp and Arg399Gln) are associated with the clinical outcome of platinum-based chemotherapy in gastric cancer patients based on published studies. Meta-analysis was performed to provide a systematic review of the findings... Read More»
- Genet. Mol. Res. 13(1):
- http://dx.doi.org/2014.March.6.2
- DOI:
- http://dx.doi.org/10.4238/2014.March.6.2
Target fishing of glycopentalone using integrated inverse docking and reverse pharmacophore mapping approach
Authors: A.B. Gurung, M.A. Ali, A. Bhattacharjee, K.M. Al-Anazi, M.A. Farah, F.M. Al-Hemaid, F.M. Abou-Tarboush, J. Lee, S.Y. Kim and F.S.M. Al-Anazi
Glycopentalone isolated from Glycosmis pentaphylla (family Rutaceae) has cytotoxic and apoptosis inducing effects in various human cancer cell lines; however, its mode of action is notknown. Therefore, target fishing of glycopentalone using a combined approach of inverse docking and reverse pharmacophore mapping approach was used to identify potential tar.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038544
- DOI:
- 10.4238/gmr.15038544
Upregulation of miR-3658 in bladder cancer and tumor progression
Authors: Y.J. Chen, H.F. Wang, M. Liang, R.C. Zou, Z.R. Tang and J.S. Wang
Despite increasing advances in surgical techniques and adjuvant chemotherapies, bladder cancer remains the ninth leading cause of male malignancy-associated deaths worldwide. Several microRNAs (miRNAs) have been identified to be closely associated with the progression and prognosis of, and response to treatments in various hum.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15049048
- DOI:
- 10.4238/gmr15049048
Combination of IL-6, IL-10, and MCP-1 with traditional serum tumor markers in lung cancer diagnosis and prognosis
Authors: Y.W. Pan, Z.G. Zhou, M. Wang, J.Q. Dong, K.P. Du, S. Li, Y.L. Liu, P.J. Lv and J.B. Gao
Early detection and treatment is critically important for lung cancer patients. Inflammatory mediators such as IL-6, IL-10, and MCP-1 participate in lung cancer regulation. CEA, CA125, and ProGRP are commonly used serum tumor markers for lung cancer. In this study, we assessed the sensitivity and specificity of CEA, CA125, and.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048949
- DOI:
- 10.4238/gmr15048949
Correlation between gene polymorphisms of CYP1A1, GSTP1, ERCC2, XRCC1, and XRCC3 and susceptibility to lung cancer
Authors: H.X. Liu, J. Li and B.G. Ye
Lung cancer is a common malignant tumor that is characterized by high morbidity and poor prognosis. Studies suggest that an individual’s genetic background affects the risk of developing lung cancer. Therefore, we investigated the relationship between gene polymorphisms and susceptibility to lung cancer. We recruited 308.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048813
- DOI:
- 10.4238/gmr15048813
Association of DNMT1 and DNMT3B polymorphisms with breast cancer risk in Han Chinese women from South China
Authors: M.-Y. Sun X.-X. Yang W.-W. Xu G.-Y. Yao H.-Z. Pan M. Li
Patterns of DNA methylation are established and maintained by a family of DNA methyltransferases (DNMTs). Aberrant promoter DNA methylation of tumor suppressor genes is found in breast cancer. Association studies between DNMT gene polymorphisms and breast cancer in various populations have reported inconsistent results. This study assessed the associations o.. Read More»
- Genet. Mol. Res. 11(4):
- 2012.September.26.1
- DOI:
- 10.4238/2012.September.26.1