Cancer
IGFBP-3 A-202C and C2133G polymorphisms and colorectal cancer risk: a meta-analysis of case-control studies
Authors: J. Xu, L. Xu, L.T. Li, Q. You and L.S. Cha
Recent evidence suggests that genetic variations in the IGFBP-3 gene may impact susceptibility to colorectal cancer, but individually published results are inconclusive. Our meta-analysis was aimed at providing a more precise estimation of these associations. An extensive literature search was conducted for appropriate articles published before May 1, 201.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.15.1
- DOI:
- http://dx.doi.org/10.4238/2015.April.15.1
Influence of chitosan nanoparticle-mediated C-erbB-2 gene silencing on invasion and apoptosis of Hep-2 cells
Authors: W.R. Liu, L.R. Cao and G.J. Zuo
We aimed to measure the invasion ability of Hep-2 laryngeal cancer cells after treatment with C-erbB-2-small interfering RNA (siRNA)-chitosan nanoparticles, and assess the applied value of chitosan nanoparticle-mediated C-erbB-2 interference in inhibiting laryngeal cancer invasion and metastasis. Nanoparticles of approximately.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048860
- DOI:
- 10.4238/gmr15048860
GSTT1, GSTM1, and GSTP1 polymorphisms and chemotherapy response in locally advanced breast cancer
Authors: A.L. Oliveira, F.F.O. Rodrigues, R.E. Santos, T. Aoki, M.N. Rocha, C.A. Longui and M.B. Melo
The glutathione S-transferase (GST) family consists of phase II detoxification enzymes that catalyze the conjugation of toxic substances, such as chemotherapeutic agents, to glutathione. We examined whether GSTT1/GSTT1“null”, GSTM1/GSTM1“null” and GSTP1Ile105Ile/GSTP1Ile105Val polymorphisms are associat.. Read More»
- Genet. Mol. Res. 9(2):
- vol9-2gmr726
- DOI:
- 10.4238/vol9-2gmr726
Increased risk of breast cancer in individuals carrying the TNRC9 rs3803662 C>T polymorphism: a meta-analysis of case-control studies
Authors: Q. Wang, N.Y. Wang, X.M. Cao, X. Sun, D. Shen, M. Yuan and J.F. Chen
Currently, the relationship between the trinucleotide repeat containing 9 (TNRC9) rs3803662 C>T polymorphism and risk of breast cancer (BC) is uncertain. Here, we attempted to obtain a more accurate assessment of this association by conducting a meta-analysis of all eligible case-control investigations, comprising 44,820 cases and 58,316 controls. A co.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038218
- DOI:
- 10.4238/gmr.15038218
Preliminary study of the effects of �²-elemene on MCF-7/ADM breast cancer stem cells
Authors: Y. Dong, L. Li, L. Wang, T. Zhou, J.W. Liu and Y.J. Gao
We examined expression differences in breast cancer stem cells (BCSCs) of the doxorubicin-resistant breast cancer cell line MCF-7/ADM and doxorubicin-sensitive cell line MCF-7/S. The effects of Chinese medicine β-elemene on BCSCs and resistance protein expression were determined. The serum-free cell culture method was used for cell culture, and morph.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.March.27.20
- DOI:
- 10.4238/2015.March.27.20
miR-129b suppresses cell proliferation in the human lung cancer cell lines A549 and H1299
Authors: L. Zheng, Y.X. Qi, S. Liu, M.L. Shi and W.P. Yang
Lung cancer is one of the most prevalent malignant tumors, and is one of the primary causes of cancer-associated deaths. In 2002, an estimated 1.18 million lung cancer-associated deaths were recorded, accounting for 18% of cancer-related deaths and 2% of total mortality. Despite the great progress that has been made in lung ca.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048367
- DOI:
- 10.4238/gmr15048367
Serum microRNA-135a downregulation as a prognostic marker of non-small cell lung cancer
Authors: Y.K. Zhang, B. Sun and G. Sui
Abnormal expression of microRNA-135a (miR-135a) is closely associated with oncogenesis. However, the relationship between serum miR-135a levels and the clinical parameters and prognosis of non-small cell lung cancer (NSCLC) remain unclear. The study aimed to investigate the clinical significance of serum miR-135a expression in patients with NSCLC. miR-135.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038252
- DOI:
- 10.4238/gmr.15038252
Relationship of the methylenetetrahydrofolate reductase C677T polymorphism with microsatellite instability and promoter hypermethylation in sporadic colorectal cancer
Authors: Alessandra D. Clarizia, Luciana Bastos-Rodrigues, HeloÃ?Âsa B. Pena, Charles Anacleto, Benedito Rossi, Fernando A. Soares, Ademar Lopes, JosÃ?© ClÃ?¡udio C. Rocha, OtÃ?¡via Caballero, Anamaria Camargo, Andrew J.G. Simpson and SÃ?©rgio D.J. Pena
The methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism is associated with the expression of a thermolabile enzyme with decreased activity that influences the pool of methyl-donor molecules. Several studies have reported an association between C677T polymorphism and susceptibility to colorectal cancer (CRC). Conside.. Read More»
- Genet. Mol. Res. 5(2):
Mining ORESTES no-match database: can we still contribute to cancer transcriptome?
Authors: Rog�©rio da Silva Fonseca, Dirce Maria Carraro and Helena Brentani
The Human Cancer Genome Project generated about 1 million expressed sequence tags by the ORESTES method, principally with the aim of obtaining data from cancer. Of this total, 341,680 showed no similarity with sequences in the public transcript databases, referred to as “no-match”. Some of them represent low abunda.. Read More»
- Genet. Mol. Res. 5(1):
Prognostic role of the cancer stem cell marker CD44 in ovarian cancer: a meta-analysis
Authors: Y.Y. Shi and H. Jiang
This meta-analysis study aimed to investigate the correlation between CD44-positive cancer stem cells (CSCs) and clinicopathological features and its effect on the survival of ovarian cancer patients. A comprehensive literature search in the electronic databases, including PubMed, EMBASE, and Wanfang (up to December 1, 2015), was conducted. Publications a.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038325
- DOI:
- 10.4238/gmr.15038325