Cancer
Effects of Herceptin on circulating tumor cells in HER2 positive early breast cancer
Authors: J.-L. Zhang, Q. Yao, J.-H. Chen ,Y. Wang, H. Wang, Q. Fan, R. Ling,J. Yi and L. Wang
The objective of this study was to determine the changes in peripheral blood circulating tumor cells in HER2-positive early breast cancer before and after Herceptin therapy, and to explore the effects of the HER2 gene and Herceptin on circulating tumor cells. CK19 mRNA expression in peripheral blood was evaluated by qRT-PCR as an index of circulating tumo.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.March.20.20
- DOI:
- 10.4238/2015.March.20.20
TP53 Pro47Ser and Arg72Pro polymorphisms and colorectal cancer predisposition in an ethnic Kashmiri population
Authors: A.S. Sameer, Z.A. Shah, N. Syeed, M.Z. Banday, S.M. Bashir, B.A. Bhat and M.A. Siddiqi
Two TP53 gene polymorphisms at codon 47 (TP53 Pro47Ser) and at codon 72 (TP53 Arg72Pro) have been associated with susceptibility to various cancers. We carried out a case-control study and examined the genotype distribution of TP53 Pro47Ser and Arg72Pro single nucleotide polymorphisms (SNPs), using a PCR-RFLP approach, to dete.. Read More»
- Genet. Mol. Res. 9(2):
- 0.4238/vol9-2gmr751
- DOI:
- 0.4238/vol9-2gmr751
Effect of Tanshinone IIA intrathecal injections on pain and spinal inflammation in mice with bone tumors
Authors: B.X. Ren, Y. Ji, J.C. Tang, D.P. Sun, X. Hui, D.Q. Yang and X.L. Zhu
The study aimed to investigate the effect of intrathecal injections of Tanshinone IIA on thermal hyperalgesia in a mouse model of bone cancer-pain. Spinal IL-1β, IL-6, TNF-α expression levels were analyzed. C3H/HeNCrlVr male mice were assigned to groups that either received dose-dependent injections of Tanshinone IIA, or the DMSO + Sham, Tanshi.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.March.20.24
- DOI:
- 10.4238/2015.March.20.24
Study of the radiotherapy sensitization effects and mechanism of capecitabine (Xeloda) against non-small-cell lung cancer cell line A549
Authors: J.J. Zhu, J.J. Shan, L.B. Sun1 and W.S. Qiu
The purpose of this study was to explore the radiotherapy sensitization effects and the mechanism of capecitabine (Xeloda) against the non-small-cell lung cancer cell line, A549. γ-[60Co] radiation was used as the intervention method. Proliferative inhibition of capecitabine on A549 cells was determined by the CCK-8 method. The effects of capecitabi.. Read More»
- Genet. Mol. Res. 14(4):
- 2015
- DOI:
- 10.4238/2015
Relationship between genetic polymorphism of MCP-1 and non-small-cell lung cancer in the Han nationality of North China
Authors: L. Yang, G.L. Shi, C.X. Song and S.F. Xu
Monocyte chemoattractant protein 1 (MCP-1) is an important chemokine that has a dose-dependent anti-tumoral effect. Polymorphism in the MCP-1 distal regulatory region (-2518A/G) can affect the level of MCP-1 expression. We examined the polymorphisms of 112 unrelated patients with non-small-cell lung cancer (NSCLC) and 82 unrel.. Read More»
- Genet. Mol. Res. 9(2):
- vol9-2gmr740
- DOI:
- 10.4238/vol9-2gmr740
Expression and significance of SATB1 in the development of breast cancer
Authors: S. Zhang, X. Gao, Y. Ma, J. Jiang, Z. Dai, X. Yin, W. Min, W. Hui and B. Wang
Special AT-rich sequence binding protein 1 (SATB1) is a recently discovered gene regulator that can promote the growth and metastasis of breast cancer. However, its expression in different stages of breast cancer development have not been examined. We explored the role of SATB1 in the development of breast cancer by detecting SATB1 expression levels in di.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.13.10
- DOI:
- http://dx.doi.org/10.4238/2015.April.13.10
Propofol suppresses proliferation and invasion of gastric cancer cells via downregulation of microRNA-221 expression
Authors: Z.T. Wang, H.Y. Gong, F. Zheng, D.J. Liu and X.Q. Yue
Propofol is one of the extensively and commonly used intravenous anesthetic agents. The current study aimed to evaluate the effects of propofol on the behavior of human gastric cancer cells and the molecular mechanisms of this activity. The effects of propofol on SGC7901 and AGS cell proliferation, apoptosis, and invasionwere detected by MTT assay, flow c.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.17.20
- DOI:
- 10.4238/2015.July.17.20
Reduced miRNA-218 expression in pancreatic cancer patients as a predictor of poor prognosis
Authors: B.-S. Li, H. Liu and W.-L. Yang
microRNA-218 (miR-218) is a vertebrate-specific miRNA that plays a crucial role in tumorigenesis and tumor progression. This study analyzed the miR-218 expression level and clinical significance in pancreatic cancer. One hundred and seven pairs of pancreatic cancer and adjacent normal tissues were analyzed by quantitative reverse-transcriptase polymerase .. Read More»
- Genet. Mol. Res. 14(4):
- 2015
- DOI:
- 10.4238/2015
Isolation and characterization of cancer stem cells from medulloblastoma
Authors: J. Liu, N. Chi, J.Y. Zhang, W. Zhu, Y.S. Bian and H.G. Chen
Brain cancer stem cells are a subset of tumor cells present in several types of brain tumor that evade treatment regimens and are responsible for tumor recurrence. Recent reports on several tumors have suggested that Hoechst 33342 dye exclusion is a powerful technique for isolating cancer stem cell-like side population (SP) cells. In the present study, we.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.13.15
- DOI:
- http://dx.doi.org/10.4238/2015.April.13.15
Correlation of spicule sign on computed tomography scans with peripheral lung cancers associated with interstitial lung disease and chronic obstructive pulmonary disease
Authors: L. Chen, L. Gao and W.L. Wu
The objective of this study was to investigate the correlation between spicular signs on computed tomography (CT) scans and peripheral lung cancer (PLC) that is associated with interstitial lung disease (ILD) and chronic obstructive pulmonary disease (COPD). We analyzed clinical data from 96 PLC cases and grouped patients based on whether they had interst.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.March.27.9
- DOI:
- 10.4238/2015.March.27.9