Cancer
Clinical significance of lymphatic vessel invasion in stage I non-small cell lung cancer patients
Authors: K.F. Ma, X.Y. Chu and Y. Liu
The aim of this retrospective study was to evaluate the prognostic influence of lymphatic vessel invasion (LVI) in stage I non-small cell lung cancer (NSCLC) patients. From January 2004 to December 2007, LVI was detected in 57 patients with T1N0M0 NSCLC; therefore, 114 patients with the same pathology, T stage, and surgery method, but without LVI, were se.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.March.13.10
- DOI:
- 10.4238/2015.March.13.10
Germline HVR-II mitochondrial polymorphisms associated with breast cancer in Tunisian women
Authors: B. Yacoubi Loueslati, W. Troudi, L. Cherni, K.B. Rhomdhane and L. Mota-Vieira
A high incidence of somatic mtDNA polymorphisms has been reported in a wide variety of human cancers; some of them have been proposed as markers for the early detection of breast cancer. However, little attention has been paid to the potential of germline mitochondrial sequence variations as genetic risk factors for cancer. We.. Read More»
- Genet. Mol. Res. 9(3):
- vol9-3gmr778
- DOI:
- 10.4238/vol9-3gmr778
Interleukin-1B-31 gene polymorphism in Hakka gastric cancer patients in Guangdong, China
Authors: B. Qiu, H.-Y. Zou, Y.-H. Yang and C.-F. Lai
The aim of this study was to examine the interleukin-1B (IL-1B) gene promoter region -31 (IL-1B-31) polymorphism distribution characteristic of Hakka gastric cancer patients in Guangdong Province and to explore its association with gastric cancer. We used the 1:1 case-control method, matrix-assisted laser desorption ionization.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.August.7.2
- DOI:
- 10.4238/2014.August.7.2
Erlotinib enhances the CIK cell-killing sensitivity of lung adenocarcinoma A549 cells
Authors: J.Z. Mei, G.J. Liu, X.J. Zhang, J.Z. Zhao and R.T. Feng
We examined the effects and molecular mechanism of the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor erlotinib on NKG2D ligand expression in human lung adenocarcinoma A549 cells and the cytotoxicity of cytokine-induced killer cells. Flow cytometry was used to detect NKG2D ligand expression in A549 cells under effects of erlotinib and E.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.10.18
- DOI:
- http://dx.doi.org/10.4238/2015.April.10.18
Expression changes in epithelial cell adhesion molecule during colorectal cancer tumorigenesis
Authors: X.B. Chai, R.F. Song and F. Xu
We investigated the relationship between the expression of epithelial cell adhesion molecule (EpCAM) and the occurrence and development of colon cancer. Fifty colon cancer tissues and adjacent normal tissues were collected, while 40 normal intestinal mucosa tissues were collected as the blank group. EpCAM expression was detected by immunohistochemistry an.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.13.6
- DOI:
- 10.4238/2015.July.13.6
Association between IL-10 genetic variations and cervical cancer susceptibility in a Chinese population
Authors: C.Y. Bai, X.Y. Shi, J. He, J. Xue and Y. Feng
We conducted an investigation into the role of the IL-10 polymorphisms -592A/C (rs1800872), -819C/T (rs1800871), and -1082A/G (rs1800896) in cervical cancer risk in a Chinese population. A case-control study was carried out, including 165 newly diagnosed cervical cancer patients and 165 control subjects. The polymerase chain reaction-restriction fragment .. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038116
- DOI:
- 10.4238/gmr.15038116
Decreased risk of developing lung cancer in subjects carrying the CLPTM1L rs401681 (G>A) polymorphism: evidence from a meta-analysis
Authors: X.L. Zhang, X.J. Zhang, Y. Chen, Y.M. Zhang, Q. Zhang,C.X. Cao, D.Y. Gu, J.F. Shi, Y.L. Gong, J.F. Chen and C.J. Tang
A genome-wide association study revealed that a single nucleotide polymorphism, CLPTM1L - rs401681 (G>A), located at the 5p15.33 locus was signifi cantly associated with increased risk of various cancers; however, its association with lung cancer is currently inconclusive. In order to explore the relationship between this p.. Read More»
- Genet. Mol. Res. 13(1):
- http://dx.doi.org/2014.February.28.10
- DOI:
- http://dx.doi.org/10.4238/2014.February.28.10
Clinical significance of SHMT1 rs1979277 polymorphism in Asian solid tumors: evidence from a meta-analysis
Authors: T.T. Zhao, L.L. Shen, X.L. Zhang, D.Y. Gu, Q. Zhang, X.Y. Huo, C.J. Tang and J.F. Chen
Published data regarding the association between the cytosolic serine hydroxymethyltransferase (SHMT1) C1420T (Leu474Phe) polymorphism and solid tumor risk have shown inconclusive results. To derive a more precise estimation of the relationship, we performed a meta-analysis of 23 published studies that included 14,409 cancer cases and 16,996 controls. A c.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.25.12
- DOI:
- 10.4238/2015.May.25.12
Effects of simulated weightlessness on cellular morphology and biological characteristics of cell lines SGC-7901 and HFE-145
Authors: M. Zhu, X.W. Jin, B.Y. Wu, J.L. Nie and Y.H. Li
We investigated the effects of simulated weightlessness on cellular morphology, proliferation, cell cycle, and apoptosis of the human gastric carcinoma cell line SGC-7901 and the human gastric normal cell line HFE-145. A rotating clinostat was used to simulate weightlessness. The Image-Pro4.5 image analysis system was used for.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.August.7.20
- DOI:
- 10.4238/2014.August.7.20
CCR2-64I is a risk factor for development of bladder cancer
Authors: K.F. Narter, B. Agachan, S. Sozen, Z.B. Cincin and T. Isbir
Chemokines are potent proinflammatory cytokines that are implicated in numerous inflammatory diseases. Proinflammatory gene polymorphisms lead to variations in the production and concentration of inflammatory proteins. We investigated a possible association between polymorphisms in chemokine and chemokine receptor genes (MCP-1.. Read More»
- Genet. Mol. Res. 9(2):
- vol9-2gmr829
- DOI:
- 10.4238/vol9-2gmr829