Cancer
Methylenetetrahydrofolate reductase genotypes and haplotypes associated with susceptibility to colorectal cancer in an eastern Chinese Han population
Authors: H. Li, W.L. Xu, H.L. Shen, Q.Y. Chen, L.L. Hui, L.L. Long and X.L. Zhu
Methylenetetrahydrofolate reductase (MTHFR) plays an important role in folate metabolism and is involved in DNA synthesis, DNA repair and DNA methylation. The two common functional polymorphisms of MTHFR, C677T and A1298C have been associated with several diseases, including cancer. We made a case-control study to analyze a po.. Read More»
- Genet. Mol. Res. 10(4):
- 2011.December.14.8
- DOI:
- 10.4238/2011.December.14.8
Key pathways involved in prostate cancer based on gene set enrichment analysis and meta analysis
Authors: Q.Y. Ning, J.Z. Wu, N. Zang, J. Liang, Y.L. Hu and Z.N. Mo
Prostate cancer is one of the most common male malignant neoplasms; however, its causes are not completely understood. A few recent studies have used gene expression profiling of prostate cancer to identify differentially expressed genes and possible relevant pathways. However, few studies have examined the genetic mechanics o.. Read More»
- Genet. Mol. Res. 10(4):
- 2011.December.14.10
- DOI:
- 10.4238/2011.December.14.10
Implications of microRNA-197 downregulated expression in esophageal cancer with poor prognosis
Authors: T.-Y. Wang, S.-G. Liu, B.-S. Zhao, B. Qi, X.-G. Qin and W.-J. Yao
The aim of this study was to investigate the significance of the microRNA miR-197 expression level in relation to clinicopathological factors and prognoses of esophageal cancer (EC). MicroRNA was extracted using the Taqman® MicroRNA Assay from 46 EC patients at the same tumor node metastasis (TNM) stage, but with different.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.July.25.12
- DOI:
- 10.4238/2014.July.25.12
Propofol suppresses proliferation and invasion of pancreatic cancer cells by upregulating microRNA-133a expression
Authors: Z.T. Wang, H.Y. Gong, F. Zheng, D.J. Liu and T.L. Dong
Propofol is a commonly used intravenous anesthetic. We evaluated its effects on the behavior of human pancreatic cancer cells and the underlying molecular mechanisms. The effects of propofol on Panc-1 cell proliferation, apoptosis, and invasion were determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, caspase-3 activity .. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.3.28
- DOI:
- 10.4238/2015.July.3.28
HIF1A gene Pro582Ser polymorphism and susceptibility to digestive tract cancers: a meta-analysis of case-control studies
Authors: J. Xu, L. Xu, L.T. Li, Q. You, L.S. Cha
Many existing studies have demonstrated that common polymorphisms in the hypoxia inducible factor-1α (HIF-1A) may contribute to the development of digestive tract cancers, but individually published studies showed inconclusive results. This meta-analysis aimed to derive a precise estimation of the relationships between H.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.July.25.29
- DOI:
- 10.4238/2014.July.25.29
Forkhead box protein O1 mediates apoptosis in a cancer cervical cell line treated with the antitumor agent tumor necrosis factor-�±
Authors: B. Zhang, L. Gui, L. Zhu, X. Zhao, Y. Yang and Q. Li
Tumor necrosis factor-α (TNF-α) is an important pro-apoptotic cytokine, which performs a broad range of immune and inflammatory functions in several vital processes. TNF-α-induced apoptosis has been confirmed, however, relatively little is known regarding the role of forkhead box class-O 1 (FOXO1) in mediating TNF-α-induced apoptos.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.3.20
- DOI:
- 10.4238/2015.July.3.20
Meta-analysis of epidemiological studies of association of P53 codon 72 polymorphism with bladder cancer
Authors: D.B. Li, X. Wei, L.H. Jiang, Y. Wang and F. Xu
Although there have been many studies investigating a possible association between p53 codon 72 polymorphism and risk of bladder cancer, the results have been inconsistent. We conducted a meta-analysis of six epidemiological studies, which included 597 bladder cancer cases and 731 controls. Patients with bladder cancer had a s.. Read More»
- Genet. Mol. Res. 9(3):
- vol9-3gmr882
- DOI:
- 10.4238/vol9-3gmr882
Association between XRCC1 polymorphisms and laryngeal cancer susceptibility in a Chinese sample population
Authors: W.Q. Wu, L.S. Zhang, S.P. Liao, X.L. Lin, J. Zeng and D. Du
Laryngeal cancer is the major malignant tumor affecting the upper respiratory tract. Previous studies have reported on the association between XRCC1 genetic polymorphisms and risk of laryngeal cancer, but with conflicting results. In this study, we attempted to assess the association between XRCC1 Arg194Trp, Arg280His and Arg3.. Read More»
- Genet. Mol. Res. 15(4):
- gmr.15048525
- DOI:
- 10.4238/gmr.15048525
c-erbB-2 expression and prognosis of gastric cancer: a meta-analysis
Authors: Z.Q. Wang and B.J. Sun
The prognostic role of c-erbB-2 in gastric cancer is controversial. We conducted a meta-analysis to evaluate the relationship between c-erbB-2 expression and the prognosis of gastric cancer. We evaluated 20 published studies assessing the relationship between c-erbB-2 and gastric cancer prognosis. The Revman 5.0 software was used to perform literature ret.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.March.13.5
- DOI:
- 10.4238/2015.March.13.5
EGFR gene polymorphisms -216G>T and -191C>A are risk markers for gastric cancer in Mexican population
Authors: J.H. Torres-Jasso, M.E. MarÃ?Ân, E. Santiago-Luna, J.C. Leoner,J. Torres, M.T. MagaÃ?±a-Torres, F.J. Perea, B. Ibarra and J.Y. SÃ?¡nchez-LÃ?³pez
Epidermal growth factor receptor (EGFR) is a transmembrane glycoprotein with tyrosine-kinase activity that plays an important role in multiple cellular functions. EGFR overexpression has been observed in several types of tumors and it is significantly associated with disease stage, survival, prognosis, and progression of cancer. The polymorphisms -216G>.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.March.13.8
- DOI:
- 10.4238/2015.March.13.8