Cancer
Elimination of breast tumor-associated chondroitin sulfate promotes metastasis
Authors: R.D. Prinz, C.M. Willis, A. Viloria-Petit and M. Kl�¼ppel
Breast cancer is one of the leading causes of cancer-related deaths amongst women in the USA. The tumor microenvironment has been suggested to be an attractive therapeutic target for treatment of cancers. The glycosaminoglycan chondroitin sulfate, as part of the cellular microenvironment, consists of long linear chains of repe.. Read More»
- Genet. Mol. Res. 10(4):
- 2011.December.8.9
- DOI:
- 10.4238/2011.December.8.9
Identification of critical TF-miRNA-mRNA regulation loops for colorectal cancer metastasis.
Authors: C. Wang, D.Z. Hu and J.Z. Liu
To explore the potential cause of colorectal cancer metastasis, gene expression profiles, GSE21510, and miRNA expression profiles, GSE48074, were downloaded from the Gene Expression Omnibus database. Differentially expressed genes in metastatic colorectal and non metastatic colorectal cancer compared with the normal samples were identified via the limma p.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.22.19
- DOI:
- 10.4238/2015.May.22.19
Meta-analysis of the association between the HNF1B rs4430796 (A>G) polymorphism and risk of prostate cancer based on case-control studies
Authors: Y. Zhao, J. Liang, J.G. Qi, N. Yang, G. Wu, Y.L. Lin, J.Y. Cao, Q. Wang and Q.C. Wang
Genome-wide studies have reported an association between the HNF1B rs4430796 (A>G) polymorphism and prostate cancer risk, but results have been inconsistent and recent meta-analyses have been inadequate. This study aimed to integrate previous results and explore the validity of this association. Electronic searches for all relevant publications through.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.3.18
- DOI:
- 10.4238/2015.July.3.18
Identification of critical TF-miRNA-mRNA regulation loops for colorectal cancer metastasis
Authors: C. Wang D.Z. Hu and J.Z. Liu
To explore the potential cause of colorectal cancer metastasis, gene expression profiles, GSE21510, and miRNA expression profiles, GSE48074, were downloaded from the Gene Expression Omnibus database. Differentially expressed genes in metastatic colorectal and non metastatic colorectal cancer compared with the normal samples were identified via the limma p.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.22.19
- DOI:
- 10.4238/2015.May.22.19
MicroRNAs as novel biomarkers for the differentiation of malignant versus benign thyroid lesions: a meta-analysis
Authors: G.J. Zhou, M. Xiao, L.N. Zhao, J.G. Tang and L. Zhang
The aim of this meta-analysis was to systematically evaluate the diagnostic accuracy of microRNAs (miRNAs) in distinguishing malignant thyroid lesions from benign ones and to determine the potential of miRNAs as diagnostic biomarkers for thyroid cancer. The random-effect model was used to summarize the pooled estimates of diagnostic accuracy, including se.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.3.3
- DOI:
- 10.4238/2015.July.3.3
Ebp1 protein expression in cervical cancer tissue and its significance
Authors: L. Liu, D.Y. Xu, S.S. Yang and X.D. Li
The objectives of this study were to observe the changes in expression of ErbB-3 binding protein (Ebp1) in cervical cancer and to investigate their clinic significance. We detected the expression level of Ebp1 in cancerous and adjacent tissues from 56 patients with cervical cancer. We identified 21 Ebp1 positive samples (37.5%) from among the 56 cervical .. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.22.20
- DOI:
- 10.4238/2015.May.22.20
Serum level of endothelial cell-specific molecule-1 and prognosis of colorectal cancer.
Authors: H. Jiang, X.G. Fu and Y.T. Chen
We evaluated the clinical significance and explored the prognostic value of serum endothelial cell-specific molecule-1 (ESM-1) expression in colorectal cancer (CRC) in a Chinese population. Serum samples were obtained from 89 CRC patients undergoing surgical treatment and 90 healthy volunteers (control group). ESM-1 levels in serum samples from CRC patien.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.25.3
- DOI:
- 10.4238/2015.May.25.3
Prostate stem cell antigen rs2294008 (C>T) polymorphism and bladder cancer risk: a meta-analysis based on cases and controls
Authors: Y. Zhao, Z.L. Gui, S. Liao, F. Gao, Y.Z. Ge and R.P. Jia
Several published articles have evaluated the association between the prostate stem cell antigen (PSCA) rs2294008 (C>T) polymorphism and bladder cancer risk, but the results remain inconclusive. In order to derive a more precise estimation of the association, we performed a meta-analysis of four case-control studies that in.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.July.25.7
- DOI:
- 10.4238/2014.July.25.7
Genetic polymorphism in sex hormone metabolism and prostate cancer risk
Authors: E. Ersekerci, M. Sofikerim, S. Taheri, A. Demirtas and F. Halis
We compared single-nucleotide polymorphisms for point mutations in cytochrome P450 genes, including cytochrome P450c17α (CYP17), cytochrome P450 aromatase (CYP19), steroid-5-a-reductase (SRD5A2), and prostate-specific antigen (PSA) involved in androgen and estrogen production. Between January 2008 and January 2010, 90 patients were enrolled in the s.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.3.8
- DOI:
- 10.4238/2015.July.3.8
Association between EGF and VEGF functional polymorphisms and sporadic colorectal cancer in the Malaysian population
Authors: T.P. Lau, A.C. Roslani, L.H. Lian, P.C. Lee, I. Hilmi, K.L. Goh and K.H. Chua
Growth factors are polypeptides that are critical for the initiation, progression, and metastasis of cancer. Most tumor cells are capable of synthesizing particular growth factors leading to constitutive pathway activation in these cells through autocrine signaling. Epidermal growth factor (EGF) is a potent mitogenic peptide t.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.July.25.9
- DOI:
- 10.4238/2014.July.25.9