Cancer
Association between XPD Lys751Gln polymorphism and risk of head and neck cancer: a meta-analysis
Authors: H. Yuan, Y.M. Niu, R.X. Wang, H.Z. Li and N. Chen
Several studies have investigated the association between Lys751Gln polymorphism in the xeroderma pigmentosum group D (XPD) gene and risk of head and neck cancer; however, the published results are conflicting. We conducted a meta-analysis that comprised 15 published case-control studies examining the association of head and n.. Read More»
- Genet. Mol. Res. 10(4):
- 2011.November.22.6
- DOI:
- 10.4238/2011.November.22.6
Clinical significance of fibroblast growth factor receptor-3 mutations in bladder cancer: a systematic review and meta-analysis
Authors: X. Liu, W. Zhang, D. Geng, J. He, Y. Zhao and L. Yu
Mutations in the fibroblast growth factor receptor-3 (FGFR3) gene are frequently found in bladder cancer, but their prognostic value remains controversial. To globally summarize the association between FGFR3 mutations and the grade and stage of bladder cancer, and to analyze the predictive role of FGFR3 mutations with respect .. Read More»
- Genet. Mol. Res. 13(1):
- http://dx.doi.org/2014.February.20.12
- DOI:
- http://dx.doi.org/10.4238/2014.February.20.12
Significance of Ebp1 and p53 protein expression in cervical cancer
Authors: L. Liu, X.D. Li, H.Y. Chen, J.S. Cui and D.Y. Xu
In this study, the ErbB3-binding protein (Ebp1) and p53 protein expression in cervical cancer tissues, and its significance in the prognosis of the disease was investigated. Ebp1 and p53 protein expression was detected by immunohistochemical analysis in cervical cancer tissues (N = 60) and normal tissues adjacent to the cancer.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.2.19
- DOI:
- 10.4238/2015.October.2.19
Association of CYP2C19*3 gene polymorphism with breast cancer in Chinese women
Authors: C.Q. Gan, X.Y. Wang, Y.D. Cao, W.X. Ye, H. Liu and Y.Y. Sun
Cytochrome P450 (CYP) 2C19 metabolizes arachidonic acid to biologically active epoxyeicosatrienoic acids, which significantly promote proliferation of cancer cells in vitro and in vivo. We looked for a possible association between human CYP2C19*3 gene polymorphism and breast cancer in the Chinese Han population. In a Chinese H.. Read More»
- Genet. Mol. Res. 10(4):
- 2011.December.5.3
- DOI:
- 10.4238/2011.December.5.3
Correlation between liver cancer occurrence and gene expression profiles in rat liver tissue
Authors: C.S. Xu, G.P. Wang, L.X. Zhang, C.F. Chang, J. Zhi and Y.P. Hao
Liver cancer (LC) is generally characterized by malignant cell proliferation and growth; it normally develops in stages that progress from non-specific injury of the liver to liver fibrosis, liver cirrhosis, dysplasia nodules, and liver carcinoma. We used a rat model of diethylnitrosamine (DENA)-induced LC; a Rat Genome 230 2... Read More»
- Genet. Mol. Res. 10(4):
- 2011.December.14.3
- DOI:
- 10.4238/2011.December.14.3
High frequency of microsatellite instability in sporadic colorectal cancer patients in Iran
Authors: M. Moghbeli, O. Moaven, E. Dadkhah, M. Farzadnia, N.M. Roshan, H. Asadzadeh-Aghdaee, M.M. Bahar, R. Raeisossadati, M.M. Forghanifard, S.R.E.A. Bakhtiari, A. Baradaran and M.R. Abbaszadegan
Microsatellite instability in sporadic colorectal cancer patients was assessed, and the clinicopathological associations were evaluated in northeastern Iran, which is a high-risk region for gastrointestinal malignancies. Microsatellite instability (MSI)status of tumoral tissue, compared to normal tissue, was assessed with a st.. Read More»
- Genet. Mol. Res. 10(4):
- 2011.December.14.4
- DOI:
- 10.4238/2011.December.14.4
Prevalence and genotype distribution of human papillomavirus in women in the Henan Province
Authors: Y.-F. Zhi, X.-X. Cha, X.-F. Li, C. Qiu and S.-H. Rong
We studied human papillomavirus (HPV) prevalence and genotype distribution among women in the Henan Province to provide epidemiological data as a means of preventing cervical cancer and developing a vaccine. A total of 14,873 samples were genotyped by using polymerase chain reaction reverse dot-blot. The overall HPVpositive rate in the sample was 23.98% (.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.22.15
- DOI:
- 10.4238/2015.May.22.15
Meta-analysis of an association of codon 72 polymorphisms of the p53 gene with increased endometrial cancer risk
Authors: Y. Gu, X. Zhou and S.L. Zhang
Polymorphisms of the p53 gene have been associated with susceptibility to endometrial cancer. However, whether there is a specific association is still controversial. We investigated a possible association between p53 codon 72 polymorphism and endometrial cancer risk by conducting a meta-analysis. Publications addressing this .. Read More»
- Genet. Mol. Res. 10(4):
- 2011.October.31.11
- DOI:
- 10.4238/2011.October.31.11
Vascular endothelial growth factor gene polymorphisms and colorectal cancer risk: a meta-analysis
Authors: L.P. Zhou, H. Luan, X.H. Dong, G.J. Jin, D.L. Man and H. Shang
Vascular endothelial growth factor (VEGF) is an endothelial cell-specific mitogen involved in a number of pathologic processes, including angiogenesis, tumor growth and metastasis. Polymorphisms of the VEGF gene have been associated with susceptibility to colorectal cancer (CRC). However, the specific association still remains.. Read More»
- Genet. Mol. Res. 10(4):
- 2011.October.31.13
- DOI:
- 10.4238/2011.October.31.13
Tetraploidization in Wilms tumor in an infant
Authors: E.T. Valera*, M.S. Brassesco*, C.A. Scrideli and L.G. Tone
Genetic instability is frequent in human cancer. Unscheduled tetraploidization can trigger cell transformation and tumorigenesis. We made a cytogenetic analysis by Giemsa-trypsin banding of a stage I, biphasic Wilms tumor diagnosed in a 10-month-old male. An evident karyotypic heterogeneity was found. Four different subclones .. Read More»
- Genet. Mol. Res. 9(3):
- vol9-3gmr880
- DOI:
- 10.4238/vol9-3gmr880