Cancer
Relationship between DNA repair gene XPD751 single-nucleotide polymorphisms and prognosis of colorectal cancer
Authors: Y. Dong, J.W. Liu, Y.J. Gao, T. Zhou and Y.M. Chen
We examined the relationships between singlenucleotide polymorphisms (SNPs) in the DNA repair gene XPD751 and the efficacy and time to disease progression (TTP) in colorectal cancer patients after platinum-based chemotherapy. Ninety-eight patients diagnosed with advanced colorectal cancer were subjected to oxaliplatin and 5-fluorouracil combination therap.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.22.8
- DOI:
- 10.4238/2015.May.22.8
Association between GSTM1 polymorphisms and lung cancer: an updated meta-analysis
Authors: H. Liu, H.F. Ma and Y.K. Chen
The relationship between glutathione S-transferase M1 (GSTM1) genetic polymorphisms and lung cancer has been reported previously. However, the results are not consistent. Therefore, to clarify the association between GSTM1 polymorphisms and lung cancer, we performed a meta-analysis based on published studies. We used the Revman 5.0 software to perform lit.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.February.13.17
- DOI:
- 10.4238/2015.February.13.17
Expression and clinical significance of LRRC4 in benign and malignant nasopharyngeal diseases
Authors: X.-J. Zhou, Y. Wang, L.-J. Zhang and J.-H. Chen
The aim of this study was to investigate the expression of LRRC4 in nasopharyngeal carcinomas, nasopharyngeal precancerous lesions, and nasopharyngitis as well as the clinical significance of LRRC4. Fifty patients with nasopharyngeal carcinoma were selected as study subjects; 28 patients with chronic nasopharyngitis and 22 patients with nasopharyngeal pre.. Read More»
- Genet. Mol. Res. 14(4):
- 2015
- DOI:
- 10.4238/2015
Relationship between clinicopathological features and HIF-2�± in gastric adenocarcinoma
Authors: N. Li, H.X. Wang, C. Qin, X.H. Wang and F.Y. Han
Hypoxia influences tumor growth by inducing angiogenesis and genetic alterations. Hypoxia-inducible factor-2α (HIF-2α) plays an essential role in oxygen homeostasis. Expression of HIF-2α-inducible genes is associated with tumor progression. In this study, we investigated this correlation immunohistochemically and using quantitative rever.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.February.13.19
- DOI:
- 10.4238/2015.February.13.19
Investigation on the association between NLRP3 gene polymorphisms and susceptibility to primary gout
Authors: L.F. Wang, Y.J. Ding, Q. Zhao, X.L. Zhang
We conducted a case-control study to investigate the association between 3 common NALP3 polymorphisms (rs10754558, rs7512998, and rs12137901) and the susceptibility to primary gout. A total of 320 patients with primary gout and 320 controls were included in this study. The genotyping of NALP3 rs10754558, rs7512998, and rs12137901 were conducted by polymer.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.
- DOI:
- 10.4238/2015.
Clinical significance of fibroblast growth factor receptor-3 mutations in bladder cancer: a systematic review and meta-analysis..
Authors: X. Liu, W. Zhang, D. Geng, J. He, Y. Zhao and L. Yu
Mutations in the fibroblast growth factor receptor-3 (FGFR3) gene are frequently found in bladder cancer, but their prognostic value remains controversial. To globally summarize the association between FGFR3 mutations and the grade and stage of bladder cancer, and to analyze the predictive role of FGFR3 mutations with respect .. Read More»
- Genet. Mol. Res. 13(1):
- 2014.February.20.12
- DOI:
- 10.4238/2014.February.20.12
Association between MTHFR 677C/T and 1298A/C gene polymorphisms and breast cancer risk
Authors: X.F. Zhang, T. Liu, Y. Li and S. Li
ABSTRACT. We performed a case-control study to investigate the association between single nucleotide polymorphisms in the MTHFR gene (677C/T and 1298A/C) and risk of breast cancer. This case-control study included 216 breast cancer cases and 216 controls. The MTHFR 677C/T and 1298A/C gene polymorphisms were assessed by polymerase chain reaction restrictio.. Read More»
- Genet. Mol. Res. 14(4):
- 2015
- DOI:
- 10.4238/2015
Clinical applications of internal heat source analysis for breast cancer identification
Authors: F. Han, C.W. Liang, G.L. Shi, L. Wang and K.Y. Li
Nondestructive preoperative breast imaging techniques are widely used for breast cancer testing and diagnosis. This study aimed to evaluate the feasibility and efficacy of quantitative diagnosis via the thermal analysis of abnormal metabolism. Nine hundred forty-eight women who underwent breast biopsy from 2009 to 2013 were investigated. Thermal analysis .. Read More»
- Genet. Mol. Res. 14(1):
- 2015.February.13.24
- DOI:
- 10.4238/2015.February.13.24
Genetic polymorphism of the glutathione-S-transferase P1 gene (GSTP1) and susceptibility to prostate cancer in the Kashmiri population
Authors: Q. Qadri, A.S. Sameer, Z.A. Shah, A. Hamid, S. Alam, S. Manzoor and M.A. Siddiqi
Glutathione-S-transferase P1 (GSTP1) is a critical enzyme of the phase II detoxification pathway. One of the common functional polymorphisms of GSTP1 is A→G at nucleotide 313, which results in an amino acid substitution (Ile105Val) at the substrate binding site of GSTP1 and reduces catalytic activity of GSTP1. To investig.. Read More»
- Genet. Mol. Res. 10(4):
- 2011.December.6.4
- DOI:
- 10.4238/2011.December.6.4
Effect of p53 gene polymorphism on functions of prostate cancer cells
Authors: N. Chi, Z.Z. Yun, Z.H. Tan, X.Z. Li, B.T.B.G. Chen, J. Liu, L.B. Xu, K.W. Ma, S.X. Li, J.F. Liu and C.X. Liu
Prostate cancer cells were transfected with plasmids [empty plasmids, wild-type pcDNA3.1-p53 (V/V), mutant type pcDNA3.1- p53 (G/G)] to analyze the effect of p53 gene polymorphisms on the proliferation, cycle, and apoptosis of prostatic cancer cells. Empty plasmids containing wild-type pcDNA3.1-p53 (V/V) and mutant type pcDNA3.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.2.3
- DOI:
- 10.4238/2015.October.2.3