Cancer
Association of MHC class-III gene polymorphisms with ER-positive breast cancer in Chinese Han population
Authors: Q. Pan Y. Ning L.Z. Chen S. Zhang Z.Z. Liu X.X. Yang W. Wei H. Wei Q.G. Li H.N. Yue J.X. Wang
Polymorphisms of the major histocompatibility complex (MHC) have been linked to many diseases, especially autoimmune disorders. Previous studies have shown that genetic variants in MHC class III are associated with breast cancer. To determine if there is an association between MHC class III and breast cancer risk in the Chinese Han population, we carried .. Read More»
- Genet. Mol. Res. 11(4):
- 2012.September.17.1
- DOI:
- 10.4238/2012.September.17.1
Association between expression of DNA mismatch repair genes and clinical features and prognosis of patients with radical resection of colon cancer
Authors: J.B. Wang, D.L. Ma, J.Y. Li, Q.D. Sun and Y.E. Liu
The aim of this study was to investigate the clinical significance of the expression of DNA mismatch repair (MMR) genes in patients subjected to radical surgical removal of colon cancer, as well as their correlation with disease prognosis. Ninety stage II and III colon cancer patients who received laparoscopic radical resection of colon cancer at our hosp.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038388
- DOI:
- 10.4238/gmr.15038388
Epstein-Barr virus DNA associated with gastric adenocarcinoma and adjacent non-cancerous mucosa in patients from Manaus, Brazil
Authors: P.F. de Aquino P.C. Carvalho J.S. da Gama Fischer A.Q.L. de Souza J.S. Viana S.R.S. Chalub A.D.L. de Souza M.G.C. Carvalho
Gastric cancer is one of most frequent causes of death in Brazil. The city of Manaus has one of the highest incidences of this disease in Brazil. The Epstein-Barr virus (EBV) is a ubiquitous herpesvirus that is classified as a group 1 carcinogen by the International Agency for Research on Cancer. We obtained biopsies from 6 control subjects and 10 patient.. Read More»
- Genet. Mol. Res. 11(4):
- 2012.October.15.3
- DOI:
- 10.4238/2012.October.15.3
Polymorphisms of eNOS, catalase, and myeloperoxidase genes in prostate cancer in Turkish men: preliminary results
Authors: G.G. Ceylan, C. Ceylan, B. G�¼lmemmedo ��. Tonyal�±, O. Odaba�� A. G�¶zalan, �°. Kele�� and E. ��zt�¼rk
Prostate cancer (PCa) is the most common type of neoplasm in European males. Genetic and epigenetic factors contribute to PCa development and progression. In this study, we aimed to assess the relationship between PCa and polymorphisms in the genes encoding endothelial nitric oxide synthase (eNOS), catalase (CAT), and myeloperoxidase (MPO). In total, 193 .. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038543
- DOI:
- 10.4238/gmr.15038543
Genes up- and down-regulated by dermcidin in breast cancer: a microarray analysis
Authors: D.F. Moreira, B.E. Strauss, E. Vannier and J.E. Beliz�¡rio
3-fold change and p 0.005). The gene expression of 208 was reduced and of 27 was increased in the three DCD-RNAi clones compared to pLKO control clone. The expression of 77 genes (37%) encoding for enzymes involved in amino acid metabolism, glucose metabolism and oxidoreductase activity and several genes required for cell surv.. Read More»
- Genet. Mol. Res. 7(3):
- vol7-3x-meeting009
- DOI:
- 10.4238/vol7-3x-meeting009
Interleukin-8 expression associated with canine mammary tumors
Authors: D.A.P.C. Zuccari, R. Castro, G.B. Gelaleti and U.M. Mancini
The use of prognostic markers for mammary cancer is important for routine diagnosis and research. Interleukin-8 (IL-8) is a chemotactic cytokine, produced by several cell types in response to inflammation. The expression, regulation and function of IL-8 in dogs are little known. Recent studies have associated angiogenesis and .. Read More»
- Genet. Mol. Res. 10(3):
- vol10-3gmr1145
- DOI:
- 10.4238/vol10-3gmr1145
DNA repair gene polymorphisms and susceptibility to familial breast cancer in a group of patients from Campinas, Brazil
Authors: Rozany Mucha Dufloth, Sandra Costa, Fernando Schmitt and Luiz Carlos Zeferino
Several studies have reported that the genes involved in DNA repair and in the maintenance of genome integrity play a crucial role in protecting against mutations that lead to cancer. Epidemiologic evidence has shown that the inheritance of genetic variants at one or more loci results in a reduced DNA repair capacity and in an.. Read More»
- Genet. Mol. Res. 4(4):
Low levels of serum miR-99a is a predictor of poor prognosis in breast cancer
Authors: J. Li, Z.J. Song, Y.Y. Wang, Y. Yin, Y. Liu and X. Nan
MicroRNA (miRNA) deregulation has been previously linked to the initiation and development of breast cancer. Although miR-99a is aberrantly expressed in many types of cancers, including breast cancer, the serum miR-99a expression level in breast cancer and its clinical significance remains unknown. Blood samples were obtained from 72 patients with breast .. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038338
- DOI:
- 10.4238/gmr.15038338
Investigation on ERCC5 genetic polymorphisms and the development of gastric cancer in a Chinese population
Authors: L.Q. Yang, Y. Zhang and H.F. Sun
Our study aimed to investigate the role of 2 ERCC5 promoter SNPs (rs2094258 and rs751402) in the development of gastric cancer in the Chinese population. The present hospital-based case-control study consisted of 155 patients with gastric cancer and 246 healthy controls recruited between March 2012 and December 2014. Genotyping for the rs2094258 and rs751.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038364
- DOI:
- 10.4238/gmr.15038364
TGF-�²1 polymorphisms and familial aggregation of liver cancer in Guangxi, China
Authors: P.Q. Wan, J.Z. Wu, L.Y. Huang, J.L. Wu, Y.H. Wei and Q.Y. Ning
The goal of present study was to investigate the relationship between polymorphisms of TGF-β1 and familial aggregation of liver cancer in Guangxi Zhuang, Han, and Yao populations. We conducted a population-based case-control family study of liver cancer in Guanxi, China. A total of 214 individuals from 37 case families were surveyed for polymorphisms.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.27.3
- DOI:
- 10.4238/2015.July.27.3