Comparative genetic variability between broodstock and offspring populations of Korean starry flounder used for stock enhancement in a hatchery by using microsatellite DNA analyses
Authors: H.S. An, E.-H. Shin, J.W. Lee, M.M. Nam, J.I. Myeong and C.M. An
Korean starry flounder, Platichthys stellatus (Pleuronectidae), is one of the most economically important fishery resources in Korea. We investigated the effect of current artificial reproduction in a hatchery facility, genetic divergence between the broodstock and their offspring populations of starry flounder in a hatchery strain to be stocked into natu.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.December.4.19
- DOI:
- 10.4238/2013.December.4.19
Aberrant DNA methylation of MGMT and hMLH1 genes in prediction of gastric cancer
Authors: J. Jin, L. Xie, C.H. Xie and Y.F. Zhou
We aimed to explore the association between aberrant DNA methylation of the O(6)-methylguanine-DNA methyltransferase (MGMT) and human mutL homolog 1 (hMLH1) genes with gastric cancer. A total of 283 gastric cancer patients who were confirmed by pathological diagnosis were included in our study. Aberrant DNA methylation of MGMT.. Read More»
- Genet. Mol. Res. 13(2):
- http://dx.doi.org/2014.May.30.9
- DOI:
- http://dx.doi.org/10.4238/2014.May.30.9
Insulin-like growth factor binding protein-3 (IGFBP-3) genetic variant and the risk of esophageal squamous cell carcinoma in a Chinese population
Authors: H.-P. Yang, J.-F. Liu, J. Rao, X.-M. Zhang, H.-L. Qian, X.-Q. Niu and Z.-L. Zhao
Insulin-like growth factor binding protein-3 (IGFBP-3) exerts anti-proliferative or pro-apoptotic effects through IGF-dependent as well as IGF-independent mechanisms in vitro. The purpose of this study was to examine the association between genetic variants in IGFBP-3 (rs2270628) and the risk of esophageal squamous cell carcin.. Read More»
- Genet. Mol. Res. 13(2):
- http://dx.doi.org/2014.May.30.10
- DOI:
- http://dx.doi.org/10.4238/2014.May.30.10
Sos recruitment system for the analysis of the interaction between sulfatase-modifying factor 2 subtypes and interleukin-13
Authors: W.Y. Zhang1*, H.Y. Liang1,2*, C. Yang1, L. Xue1 and X.F. Jiang1,2
(IL)-13 is a central mediator in allergic asthma. Our previous results have indicated that sulfatase-modifying factor 2 (SUMF2) interacts with IL-13 and inhibits its secretion. In this study, we investigated the interactions between SUMF2 subtypes and 2 types of IL-13. Wild type IL-13 (wh-IL-13) and its mutated counterpart (mh-IL-13) were analyzed and clo.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.November.18.15
- DOI:
- 10.4238/2013.November.18.15
Effect of MPO/H2O2/NO- system on nitric oxide-mediated modification of TTR amyloid and serum TTR in FAP ATTR Val30Met patients
Authors: J.P. Liu, Q.Y. Wang, F. Zheng, J.H. Lu, P. Ge, Y.J. Gu and X.G. Sun
Amyloid deposits consist of protein fibrils and amorphous material, and this deposition is related to oxidative stress. Previously, we demonstrated the presence of high-density lipoproteins and/or lipids in amyloid deposits of familial amyloid polyneuropathy patients. In this study, the presence of myeloperoxidase (MPO) in amy.. Read More»
- Genet. Mol. Res. 13(2):
- 2014.April.3.9
- DOI:
- 10.4238/2014.April.3.9
Pre-treatment with glutamine reduces genetic damage due to cancer treatment with cisplatin
Authors: R.J. Oliveira, E.S. Sassaki, A.C.D. Monreal, M.T.F.D. Monreal,J.R. Pesarini, M.O. Mauro, R. Matuo, A.F. Silva, N.N. Zobiole,J.M. Siqueira, L.R. Ribeiro, M.S. Mantovani
Cisplatin is an effective antineoplastic drug. However, it provokes considerable collateral effects, including genotoxic and clastogenic activity. It has been reported that a diet rich in glutamine can help inhibit such collateral effects. We evaluated this activity in 40 Swiss mice, distributed into eight experimental groups:.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.December.2.2
- DOI:
- 10.4238/2013.December.2.2
Analysis of differentially expressed genes in various stages of Duchenne muscular dystrophy by using a network view
Authors: D. Wang, Z.J. Wang, X.X. Song, L.H. Pu, X. Li and Y. Wang
Duchenne muscular dystrophy (DMD), which is caused by mutations in the X-linked dystrophin gene, is a severe and progressive neuromuscular disease with no available cure. By integrating 2 microarray datasets from the Gene Expression Omnibus, we identified differentially expressed genes in 2 stages of DMD and systematically explored their potential disease.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.October.10.13
- DOI:
- 10.4238/2013.October.10.13
Impact of MTHFR polymorphisms on methylation of MGMT in glioma patients from Northeast China with different folate levels
Authors: N. Liu1, J. Jiang1, Y.J. Song2, S.G. Zhao3, Z.G. Tong4, H.S. Song1, H. Wu1, J.Y. Zhu1, Y.H. Gu1, Y. Sun1, W. Hua1 and J.P. Qi1
Hypomethylation of the O6-methylguanine-DNA-methyltransferase (MGMT) promoter in glioma cells has been associated with temozolomide resistance. S-adenosylmethionine (SAM), which is produced during folate metabolism, is the main source of methyl groups during DNA methylation... Read More»
- Genet. Mol. Res. 12(4):
- 2013.October.29.10
- DOI:
- 10.4238/2013.October.29.10
Effects of atorvastatin in combination with ezetimibe on carotid atherosclerosis in elderly patients with hypercholesterolemia
Authors: P. Luo, L. Li, L.X. Wang, H.H. Zhu, S. Du, S.L. Wu, Y.G. Han and G.G. Wang
The aim of this study was to observe the effects of atorvastatin combined with ezetimibe on carotid atherosclerosis in elderly patients with hypercholesterolemia. A total of 84 elderly hypercholesterolemic patients complicated with carotid atherosclerosis were divided into control group (atorvastatin alone) and combined group .. Read More»
- Genet. Mol. Res. 13(2):
- 2014.April.3.10
- DOI:
- 10.4238/2014.April.3.10
HMGB3 characterization in gastric cancer
Authors: Y. Gong, Y. Cao, L. Song, J. Zhou, C. Wang, B. Wu
Gastric cancer is a major health problem worldwide; it is the second most common cause of cancer death in the world. Recent studies indicate that the high-mobility group (HMG) of chromosomal proteins is associated with cancer progression. However, HMGB3 has been little studied. We analyzed the co-expression network between HMG.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.December.2.1
- DOI:
- 10.4238/2013.December.2.1