PKR and HMGB1 expression and function in rheumatoid arthritis
Authors: W.J. Wang, S.J. Yin and R.Q. Rong
The pathogenesis of rheumatoid arthritis (RA) is characterized by inflammation. We aimed to examine the roles of double-stranded RNA-activated protein kinase (PKR) and high-mobility group box chromosomal protein 1 (HMGB1) in a rat model of RA. Male SD rats were divided into three groups: control, RA model, and intervention (RA model plus treatment). The m.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.22.11
- DOI:
- 10.4238/2015.December.22.11
Development and evaluation of a loop-mediated isothermal amplification assay for detection of Ehrlichia canis DNA in naturally infected dogs using the p30 gene
Authors: V.C. Pinhanelli, P.N.M. Costa, G. Silva, D.M. Aguiar, C.M.L. Silva, A.L. Fachin and M. Marins
Canine monocytic ehrlichiosis (CME) is a common tick-borne disease caused by the rickettsial bacterium Ehrlichia canis (Rickettsiales: Anaplasmataceae). In view of the different stages and variable clinical signs of CME, which can overlap with those of other infections, a conclusive diagnosis can more readily be obtained by combining clinical and hematolo.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.22.13
- DOI:
- 10.4238/2015.December.22.13
Elevated expression of CXCR4 and correlation with clinicopathological features and prognosis of non-small cell lung cancer patients: a meta-analysis
Authors: H. Wang, F. Xie, Z. Hu and L. Chen
The specific correlation between CXCR4 expression and survival in non-small cell lung cancer (NSCLC) has been investigated independently; however, these have yielded inconsistent results. Therefore, we examined the exact relationship between CXCR4 expression and NSCLC in this meta-analysis. The bibliographic databases in English and Chinese were carefully.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.22.14
- DOI:
- 10.4238/2015.December.22.14
Comparative transcriptome analysis of Nile tilapia (Oreochromis niloticus) in response to alkalinity stress
Authors: Y. Zhao, J. Wang, J. Thammaratsuntorn, J.W. Wu, J.H. Wei, Y. Wang, J.W. Xu and J.L. Zhao
To identify genes of potential importance to alkalinity tolerance, RNA sequencing (RNA-Seq) was performed to survey gill transcriptome profiles from freshwater (FW) and alkaline water (AW) exposed Nile tilapia (Oreochromis niloticus). A total of 22,724,036 (AW)/16,461,040 (FW) single-end reads were generated in which 20,304,348 (AW)/14,681,290 (FW) reads .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.22.16
- DOI:
- 10.4238/2015.December.22.16
miR-125a-5p expression is associated with the age of breast cancer patients
Authors: H. He, F. Xu, W. Huang, S.Y. Luo, Y.T. Lin, G.H. Zhang, Q. Du and R.H. Duan
Dysregulated miR-125 observed in multiple cancer types has suggested that it is involved in malignant proliferation and invasion. However, the clinical significance of miR-125 in human breast cancer (BC) has not yet been fully elucidated. In the present study, the expression of miR-125a-5p/3p and miR-125b in 143 pairs of BC and normal adjacent tissues (NA.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.22.17
- DOI:
- 10.4238/2015.December.22.17
An insight in the genetic control and interrelationship of some quality traits in Brassica napus
Authors: S. Ahmad, H.A. Sadaqat, M.H.N. Tahir and F.S. Awan
A study on three leading lines (KN-256, KN-257, and KN-258) of Brassica napus and an approved variety, Punjab-Sarson, was conducted to gain insight into the genetic control of some quality traits using generation mean analysis. Our results showed that additive gene action predominated in the inheritance of oil content and erucic acid in cross KN-256 x KN-.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.22.19
- DOI:
- 10.4238/2015.December.22.19
Bortezomib-based treatment of acute antibody-mediated rejection: a case report
Authors: Q. Wang, X.L. Li, X.G. Xu, B.Y. Shi, Z.M. Zhang, Z.L. Li, Y. Han, W.Q. Zhou, C.Q. Chen, M. Cai and X. Zhang
Antibody-mediated rejection (AMR) is an important factor affecting survival after renal transplantation. A highly selective proteasome inhibitor, bortezomib, clears activated plasma cells from the body and has important therapeutic effect on AMR. We investigated the effects of bortezomib on AMR in a patient after a second renal transplant. Biopsy confirme.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.22.20
- DOI:
- 10.4238/2015.December.22.20
Effect of odanacatib on root resorption and alveolar bone metabolism during orthodontic tooth movement
Authors: X.X. Wei, J.P. Chu, Y.Z. Zou, N. Ru, S.X. Cui and Y.X. Bai
The aim of this study was to investigate the effect of local administration of odanacatib (ODN) on orthodontic root resorption and the status of alveolar bone metabolism in rat molars. All specimens were scanned using microcomputed tomography and then the raw images were reconstructed. The total volume of the root resorption craters of the 60 g-NS (normal.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.22.23
- DOI:
- 10.4238/2015.December.22.23
Clinical significance of serum miR-196a in cervical intraepithelial neoplasia and cervical cancer
Authors: P. Liu, F. Xin and C.F. Ma
Previous studies have reported that miR-196a is upregulated in cervical cancer tissues and cell lines. However, whether serum miR-196a is increased in patients with cervical cancer or cervical intraepithelial neoplasia (CIN), and its potential clinical value remained unknown. In total, 105 cervical cancer patients, 86 CIN patients, and 50 healthy voluntee.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.22.25
- DOI:
- 10.4238/2015.December.22.25
Comparison of eight methods of genomic DNA extraction from babassu
Authors: J.P.G. Viana, A.N.C. Borges, A.C.A. Lopes, R.L.F. Gomes, F.B. Britto, P.S.C. Lima and S.E.S. Valente
Babassu (Orbignya phalerata Martius) is one of the most important palms in Brazil because of the largest morphological variation, wide geographic distribution, and high socio-economic importance. The diversity present in babassu germplasm should be protected against loss to ensure their use with high productivity. Study of the available variability in pop.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.22.26
- DOI:
- 10.4238/2015.December.22.26