Borax-induced apoptosis in HepG2 cells involves p53, Bcl-2, and Bax
Authors: Y. Wei1, F.J. Yuan, W.B. Zhou, L. Wu, L. Chen, J.J. Wang and Y.S. Zhang
Borax, a boron compound and a salt of boric acid, is known to inhibit the growth of tumor cells. HepG2 cells have been shown to be clearly susceptible to the anti-proliferative effects of borax. However, the specific mechanisms regulating this effect are poorly understood. This study aimed to investigate the pathways underlyin.. Read More»
- Genet. Mol. Res. 15(2):
AGER genetic polymorphisms increase risks of breast and lung cancers
Authors: N.C. Yin, X.P. Lang, X.D. Wang and W. Liu
We evaluated the associations between three common polymorphisms in the AGER gene and the risks of breast (BC) and lung (LC) cancer using meta-analysis. A systematic electronic search of the literature was conducted to identify all potential correlation studies in Embase, Web of Science, Cochrane Library, CINAHL, PubMed, CISCOM, China BioMedicine (CBM), a.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.22.2
- DOI:
- 10.4238/2015.December.22.2
Effect of neural stem cell transplantation combined with erythropoietin injection on axon regeneration in adult rats with transected spinal cord injury
Authors: Y. Zhao, Y. Zuo, X.L. Wang, H.J. Huo, J.M. Jiang, H.B. Yan and Y.L. Xiao
We investigated the effect of neural stem cells (NSC) and erythropoietin (EPO) on axon regeneration in adult rats with transected spinal cord injury, and provided an experimental basis for clinical treatment. Forty Wistar rats with T10-transected spinal cord injury were randomly divided into four groups of ten rats: a control group (group A), an NSC-trans.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.22.4
- DOI:
- 10.4238/2015.December.22.4
Effects of prolonged anesthesia with dexmedetomidine, fentanyl, or remifentanil on the self-renewal of mouse embryonic stem cells
Authors: N. Zhang, Y.R. Cai, X.W. Yi, Y.N. Xiao, B. Chen and W.X. Li
Previous study has indicated that exposure to anesthesia in early development leads to neuro-apoptosis and is followed by long-term cognitive dysfunction. Given that larger numbers of pregnant women currently receive anesthesia during the first trimester, we wanted to mimic this process in vitro using mouse embryonic stem cells (mESCs) and to explore how .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.22.5
- DOI:
- 10.4238/2015.December.22.5
Lack of association between IL-10 -1082G/A polymorphism and chronic periodontal disease in adults
Authors: R. Hannum, F.R. Godoy , A.S. da Cruz, T.C. Vieira, L.B. Minasi, D. de M. e Silva, C.C. da Silva and A.D. da Cruz
Because of the complex interaction between periodontal pathogens and the host defense system, periodontitis is considered an inflammatory disorder of bacterial etiology that results in periodontal tissue damage. Genetic mechanisms may interfere with the gene expression of important inflammation mediators, modulating the immunologic response of an individu.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.22.7
- DOI:
- 10.4238/2015.December.22.7
Joint analysis of beef growth and carcass quality traits through calculation of co-variance components and correlations
Authors: H.R. Mirzaei, A.P. Verbyla and W.S. Pitchford
A joint growth-carcass model using random regression was used to estimate the (co)variance components of beef cattle body weights and carcass quality traits and correlations between them. During a four-year period (1994-1997) of the Australian “southern crossbreeding project”, mature Hereford cows (N = 581) were ma.. Read More»
- Genet. Mol. Res. 10(1):
- vol10-1gmr1108
- DOI:
- 10.4238/vol10-1gmr1108
Detection of soluble expression and in vivo interactions of the inner membrane protein OppC using green fluorescent protein
Authors: Q.J. Xiang, J.F. Zhai, M. Zhang and B. Zhang
In this study, the in vivo interaction system of oligopeptide permease (Opp) proteins was analyzed, and a high expression system of inner membrane protein OppC was constructed by flexible usage of the green fluorescent protein (GFP). The Escherichia coli OppC gene, which encodes a transmembrane component of oligopeptide transporter, was cloned into differ.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.22.8
- DOI:
- 10.4238/2015.December.22.8
Isolation and characterization of eight polymorphic microsatellite loci for the coconut pest, Brontispa longissima (Coleoptera: Hispidae)
Authors: C.L. Ma, H.L. Wu, H.Y. Hu, X. Wu, G.C. Ma, Y.G. Fu and Z.Q. Peng
Brontispa longissima is one of the most serious insect pests of coconut in Southeast Asia; it was first discovered on Hainan Island in June 2002. Despite the economic risk associated with this pest, genetic aspects of the invasion process have remained relatively unexplored. Using microsatellite markers, we investigated the po.. Read More»
- Genet. Mol. Res. 10(1):
- vol10-1gmr1008
- DOI:
- 10.4238/vol10-1gmr1008
Genetic diversity of turmeric germplasm (Curcuma longa; Zingiberaceae) identified by microsatellite markers
Authors: M.S. Sigrist, J.B. Pinheiro, J.A. Azevedo Filho and M.I. Zucchi
Turmeric (Curcuma longa) is a triploid, vegetatively propagated crop introduced early during the colonization of Brazil. Turmeric rhizomes are ground into a powder used as a natural dye in the food industry, although recent research suggests a greater potential for the development of drugs and cosmetics. In Brazil, little is k.. Read More»
- Genet. Mol. Res. 10(1):
- vol10-1gmr1047
- DOI:
- 10.4238/vol10-1gmr1047
A case-control study of CYP2E1 (PstI) and CYP1A1 (MspI) polymorphisms in colorectal cancer
Authors: M.A. Proen�§a, G.M.M. Fernandes, A. Russo, R.B. Lelis, J.G. Netinho, G.S. Cunrath, A.E. Silva, E.M. Goloni-Bertollo and E.C. Pavarino
Polymorphisms in genes encoding P450 cytochrome enzymes may increase the risk of sporadic colorectal cancer (SCRC). Here we investigated the association between SCRC and CYP2E1 (PstI) and CYP1A1 (MspI) polymorphisms in a case-control study. Moreover, we sought to determine any possible associations between this disease and the sociodemographic factors. We.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.22.10
- DOI:
- 10.4238/2015.December.22.10