Expression of human papillomavirus E6 and E7 oncoprotein mRNA in women with low-grade squamous intraepithelial lesions or less
Authors: D.C. Casagrande, J.C.L. Ribalta, K.D.P.F. Leite, M. Schimidt and N.M.D.G. Speck
We verified the prevalence of human papillomavirus (HPV) E6/E7 protein mRNA expression in patients with low-grade squamous intraepithelial lesions (LSILs) and negative cervicovaginal cytology. To investigate the relationship between mRNA expression and viral infection type, we assessed genotyping in single infections. Samples from 825 women were submitted.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017916
- DOI:
- 10.4238/gmr.15017916
A network approach predicts NFKBIA and BIRC3 as pathogenic genes in childhood asthma
Authors: X.M. Gao
This study aimed to predict pathogenic genes of childhood asthma based on molecular interaction networks and gene expression data. Known pathogenic genes identified from the human protein-protein interaction network were denoted as seed genes, and were included in network A. We extracted sub-network B (pathogenic network), whi.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028226
- DOI:
- 10.4238/gmr.15028226
Genetic analysis of grain shape and weight after cutting rice husk
Authors: J.R. Fu, L.X. Zhu, X.T. Sun, D.H. Zhou, L.J. Ouyang, J.M. Bian, H.H. He and J. Xu
Grain shape and weight are the most important components of rice yield and are controlled by quantitative trait loci (QTLs). In this study, a double-haploid population, derived from the cross of japonica CJ06 and indica TN1, was used to analyze QTLs for grain shape and weight under two conditions: normal growth with unbroken husk and removing partial husk.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.21.47
- DOI:
- 10.4238/2015.December.21.47
Single nucleotide polymorphisms associated with carcass traits in a population of Brahman and Brahman-influenced steers
Authors: A.M. Royer, C. Shivers, D.G. Riley, M.A. Elzo and M.D. Garcia
Brahman cattle are important in tropical regions due to their ability to tolerate excessive heat and parasites. However, Brahman cattle exhibit lower carcass quality characteristics when compared to Bos taurus breeds. The objective of this study was to evaluate potential associations between single nucleotide polymorphisms (SN.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028280
- DOI:
- 10.4238/gmr.15028280
Genetic diversity of the Neotropical tree Hancornia speciosa Gomes in natural populations in Northeastern Brazil
Authors: H.J. Jimenez, L.S.S. Martins, A.V.V. Montarroyos, J.F. Silva Junior, A.L. Alzate-Marin and R.M. Moraes Filho
Mangabeira (Hancornia speciosa Gomes) is a fruit tree of the Apocynaceae family, which is native to Brazil and is a very important food resource for human populations in its areas of occurrence. Mangabeira fruit is collected as an extractive activity, and no domesticated varieties or breeding programs exist. Due to a reduction in the area of ecosystems wh.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.21.48
- DOI:
- 10.4238/2015.December.21.48
Inducing autotetraploids in cassava using oryzalin and colchicine and their in vitro morphophysiological effects
Authors: M. de J. da S. de Carvalho, V.B. Gomes, A. da S. Souza, F.F. Aud, J.A. Santos-Serejo and E.J. Oliveira
Polyploid induction has been used for plant breeding to produce bigger and more robust plants than diploid types. The present study aimed to develop a methodology for in vitro induction of polyploidy in cassava. Apical and lateral microcuttings from the BRS Formosa variety were treated with six oryzalin concentrations for 24 and 48 h. The same methodology.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028281
- DOI:
- 10.4238/gmr.15028281
Correlation of androgen receptor and SRD5A2 gene mutations with pediatric hypospadias in 46, XY DSD children
Authors: X.H. Fu, W.Q. Zhang and X.S. Qu
We performed an exploratory study by analyzing the correlation of 46, XY disorders of sex development (46, XY DSD) with androgen receptor (AR) and steroid 5α-reductase-2 (SRD5A2) gene mutations and a safety analysis of dihydrotestosterone (DHT) gel treatment for pediatric micropenis. We collected samples from 76 pediatric patients with 46, XY DSD an.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15018232
- DOI:
- 10.4238/gmr.15018232
One missense mutation in exon 2 of the PAX5 gene in Iran
Authors: S. Yazdanparast, S.R. Khatami, H. Galehdari and K. Jaseb
The PAX5 gene, which encodes the B-cell specific activator protein, is one of the most important factors in determination of B-cell development. This gene is the main target of somatic mutations in acute B lymphoblastic leukemia (B-ALL). For example, point mutations, deletions, as well as other gene rearrangements may lead to several forms of B-cell malig.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.22.1
- DOI:
- 10.4238/2015.December.22.1
Borax-induced apoptosis in HepG2 cells involves p53, Bcl-2, and Bax
Authors: Y. Wei1, F.J. Yuan, W.B. Zhou, L. Wu, L. Chen, J.J. Wang and Y.S. Zhang
Borax, a boron compound and a salt of boric acid, is known to inhibit the growth of tumor cells. HepG2 cells have been shown to be clearly susceptible to the anti-proliferative effects of borax. However, the specific mechanisms regulating this effect are poorly understood. This study aimed to investigate the pathways underlyin.. Read More»
- Genet. Mol. Res. 15(2):
AGER genetic polymorphisms increase risks of breast and lung cancers
Authors: N.C. Yin, X.P. Lang, X.D. Wang and W. Liu
We evaluated the associations between three common polymorphisms in the AGER gene and the risks of breast (BC) and lung (LC) cancer using meta-analysis. A systematic electronic search of the literature was conducted to identify all potential correlation studies in Embase, Web of Science, Cochrane Library, CINAHL, PubMed, CISCOM, China BioMedicine (CBM), a.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.22.2
- DOI:
- 10.4238/2015.December.22.2