Copy number imbalances detected with a BAC-based array comparative genomic hybridization platform in congenital diaphragmatic hernia fetuses
Authors: I.N. Machado, J.K. Heinrich, R. Barini and C.F.A. Peralta
Congenital diaphragmatic hernia (CDH) is a phenotypically and genetically heterogeneous disorder, with a complex inheritance pattern. Structural abnormalities of almost all chromosomes have been described in association with CDH. We made a molecular analysis through array comparative genomic hybridization (array CGH) of a grou.. Read More»
- Genet. Mol. Res. 10(1):
- vol10-1gmr1001
- DOI:
- 10.4238/vol10-1gmr1001
Ketamine used as an acesodyne in human breast cancer therapy causes an undesirable side effect, upregulating anti-apoptosis protein Bcl-2 expression
Authors: H. He, J. Chen, W.P. Xie, S. Cao, H.Y. Hu, L.Q. Yang and B. Gong
Ketamine is a dissociative anesthetic agent that has been widely used in surgery and for relieving pain in chronic cancer patients. We applied ketamine to breast cancer cell line MDA-MB-231 to detect the effect of treatment and molecular mechanisms involved. We found that ketamine can upregulate the level of anti-apoptosis protein Bcl-2, which promotes br.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.January.4.7
- DOI:
- 10.4238/2013.January.4.7
New record and cytogenetic analysis of Psammolestes tertius Lent & Jurberg, 1965 (Hemiptera, Reduviidae, Triatominae) from Bahia State, Brazil
Authors: J. Oliveira, K.C.C. Alevi, E.O.L. Fonseca, O.M.F. Souza,C.G.S. Santos, M.T.V. Azeredo-Oliveira and J.A. da Rosa
This paper reports on the first occurrence of Psammolestes tertius in the Chapada Diamantina region, located in the city of Seabra, Bahia State, in northeastern Brazil. Following an active search, 24 P. tertius specimens were collected from Phacellodomus rufifrons (rufous-fronted thornbird) nests. The insects did not present a.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028004
- DOI:
- 10.4238/gmr.15028004
Molecular markers located on the DGAT1, CAST, and LEPR genes and their associations with milk production and fertility traits in Holstein cattle
Authors: R. Hill, A. Canal, K. Bondioli, R. Morell and M.D. Garcia
The objective of the present study was to investigate single nucleotide polymorphisms (SNPs) located in three candidate genes previously reported to have effects on fertility and milk production traits in a population of 123 Holstein cows. The milk production traits evaluated included lifetime averages of milk yield, protein c.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017794
- DOI:
- 10.4238/gmr.15017794
Polymorphisms of the angiotensin II type 1 receptor gene affect antihypertensive response to angiotensin receptor blockers in hypertensive Chinese
Authors: H.T. Gong, X.L. Ma, B.X. Chen, X.Y. Xu, Q. Li, C.X. Guo and F.H. Du
The renin-angiotensin-aldosterone system plays a key role in regulating blood pressure by maintaining vascular tone and the water/sodium balance. Many antihypertensive drugs target the renin-angiotensin-aldosterone system, but the effect differs considerably among hypertensive patients. We investigated whether genetic variants of the angiotensin II type 1.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.June.21.2
- DOI:
- 10.4238/2013.June.21.2
APOA5 polymorphisms associated with lipid metabolism in Brazilian children and adolescents
Authors: E. De Fran�§a, D.S.B.S. Silva, T.F.C. Silva, C.L. Dornelles, J.G. Alves and C.S. Alho
Single nucleotide polymorphisms in the APOA5 gene have been studied for their association with metabolic syndrome. Thus, elucidating the effect of the mechanism involved in APOA5 gene polymorphisms on lipid metabolism is of great importance. In this study we aimed to determine the allelic and genotypic frequencies of -1131T>C, Ser19Trp, and intergenic .. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017809
- DOI:
- 10.4238/gmr.15017809
Mitochondrial transfer RNA mutations and hypertension
Authors: S.L. Yin, C. Lan, H. Pei, and Z.Q. Zhu
Mutations in mitochondrial DNA have been found to be associated with hypertension. Of these, mitochondrial transfer RNA (mt-tRNA) is a hot spot for these pathogenic mutations. It is generally believed that these mutations may result in the failure of mt-tRNA metabolism, thereby worsening mitochondrial dysfunction and resulting in hypertension. mt-tRNA is .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.21.42
- DOI:
- 10.4238/2015.December.21.42
A new strategy for identification of currant (Ribes nigrum L.) cultivars using RAPD markers
Authors: J. Huo, G. Yang, Y. Zhang and F. Li
We developed a new approach using RAPD fingerprints to distinguish 37 currant cultivars from northeastern China based on optimization of RAPD by choosing 11 nucleotide primers and strict screening PCR annealing temperature. We found that the manual cultivar identification diagram (MCID) approach clearly developed fingerprints from 8 different primers that.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.June.21.1
- DOI:
- 10.4238/2013.June.21.1
A computational method to predict carbonylation sites in yeast proteins
Authors: H.Q. Lv,, J. Liu, J.Q. Han, J.G. Zheng and R.L. Liu
Several post-translational modifications (PTM) have been discussed in literature. Among a variety of oxidative stress-induced PTM, protein carbonylation is considered a biomarker of oxidative stress. Only certain proteins can be carbonylated because only four amino acid residues, namely lysine (K), arginine (R), threonine (T) .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028006
- DOI:
- 10.4238/gmr.15028006
Selection for wide adaptability and high phenotypic stability of Brazilian soybean genotypes
Authors: V.M. Oliveira, O.T. Hamawaki, A.O. Nogueira, L.B. Sousa, F.M. Santos and R.L. Hamawaki
Advances in genetic enhancement techniques have led to an increase in soybean production. Thus, soybean is currently one the most economically important cultured species worldwide. The objectives of the present study were to study the interaction of soybean genotypes per environment in terms of grain productivity and to evaluate their phenotypic adaptabil.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017843
- DOI:
- 10.4238/gmr.15017843