Genetic diversity of Vriesea cacuminis (Bromeliaceae): an endangered and endemic Brazilian species
Authors: P.C.C. Ribeiro, L.C. Pinheiro, R. Domingues, R.C. Forzza, M.A. Machado and L.F. Viccini
Data about the genetic structure can help to understand the evolutionary process of natural populations as well as to drive strategies of conservation. Vriesea cacuminis, an endemic Brazilian Bromeliad, has been found in 2 areas of Minas Gerais State. One is a legal preservation unit (Ibitipoca State Park) and the other an unprotected area (Serra Negra). .. Read More»
- Genet. Mol. Res. 12(2):
- 2013.June.13.2
- DOI:
- 10.4238/2013.June.13.2
Characterization of porcine GAS6 cDNA gene and its expression analysis in weaned piglets
Authors: D. Xu, J. Jiang, J. He, C.Q. He and H.M. Ma
The growth arrest-specific 6 gene (GAS6) is a member of the family of plasma vitamin K-dependent proteins, which are able to bind to phospholipids using an N-terminal gamma-carboxyglutamic acid domain. A recent report has demonstrated that the GAS6 gene can promote fat deposition and is associated with an increased number of fat cells in mice. In order to.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.21.39
- DOI:
- 10.4238/2015.December.21.39
Vascular endothelial growth factor +936C/T polymorphism and cancer risk in Asians: a meta-analysis
Authors: X.L. Liu, Q.F. Yang and B.H. Kong
Vascular endothelial growth factor (VEGF), the most important regulator of angiogenesis and vascular permeability, is involved in various steps of carcinogenesis. The +936C/T polymorphism of the VEGF gene has been reported to affect the VEGF protein level and to be related to the susceptibility of cancer. However, the results of published studies, as well.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.June.13.1
- DOI:
- 10.4238/2013.June.13.1
Isolation and characterization of 12 polymorphic microsatellite markers for the frog Pelophylax hubeiensis
Authors: J.-C. Yan, F.-H. Zhu and H.-L. Wu
Twelve polymorphic microsatellite loci were isolated from an (AC)n- and (AG)n-enriched DNA library for the endemic Chinese frog Pelophylax hubeiensis (Ranidae). The number of alleles per locus ranged from two to eight, with a mean of 5.17. The observed and expected heterozygosities ranged from 0.226 to 0.839 and from 0.204 to .. Read More»
- Genet. Mol. Res. 10(1):
- vol10-1gmr1003
- DOI:
- 10.4238/vol10-1gmr1003
Molecular characterization and phylogenetic analysis of porcine epidemic diarrhea virus samples obtained from farms in Gansu, China
Authors: M.Z. Huang, H. Wang S.Y. Wang, D.A. Cui, X. Tuo and Y.M. Liu
Porcine epidemic diarrhea poses significant sanitation problems in the porcine industry, and has negatively affected the economy in recent years. In this study, 48 fecal specimens were collected from piglets from four intensive swine farms located in the Gansu Province of China. The molecular diversity and phylogenetic relatio.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017696
- DOI:
- 10.4238/gmr.15017696
Clinical significance of microRNA-34a in esophageal squamous cell carcinoma
Authors: X. Lin, X.Y. Xu, Q.S. Chen and C. Huang
MicroRNA-34a (miR-34a) has been found to be downregulated in esophageal squamous cell carcinoma (ESCC) tissues compared with that in normal tissues (P < 0.05), and miR-34a overexpression increased apoptosis and decreased clonogenic formation. However, the clinical significance and prognostic value of miR-34a in ESCC has not yet been investigated. In to.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.21.41
- DOI:
- 10.4238/2015.December.21.41
Meta-analysis demonstrates lack of a relationship between XRCC1-399 gene polymorphisms and susceptibility to hepatocellular carcinoma
Authors: X.Y. Zeng, J.M. Huang, J.W. Xu, Y. Xu, H.P. Yu, L. Ji and X.Q. Qiu1,
XRCC1-399 allele polymorphisms have been reported to be associated with susceptibility to hepatocellular carcinoma (HCC), but the conclusions of the various studies have been inconsistent. We conducted a meta-analysis of available studies to determine whether XRCC1-399 alleles influence susceptibility to hepatocellular carcinoma. We searched English-langu.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.March.15.5
- DOI:
- 10.4238/2013.March.15.5
Phenotypic characteristics for discrimination between advanced genotypes of Brachiaria ruziziensis
Authors: B.A. Rezende, C.B. Ribeiro, D.H.L. Teixeira, F.M.A. Gon�§alves and F. Souza Sobrinho
The aim of this study was to use multivariate methods and Pearson and partial correlations to disregard phenotypic characteristics that contribute little to differentiation between Brachiaria ruziziensis genotypes. Eighty-one genotypes of B. ruziziensis were assessed in completely randomized blocks with three replications. Ten phenotypic characteristics w.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017774
- DOI:
- 10.4238/gmr.15017774
Copy number imbalances detected with a BAC-based array comparative genomic hybridization platform in congenital diaphragmatic hernia fetuses
Authors: I.N. Machado, J.K. Heinrich, R. Barini and C.F.A. Peralta
Congenital diaphragmatic hernia (CDH) is a phenotypically and genetically heterogeneous disorder, with a complex inheritance pattern. Structural abnormalities of almost all chromosomes have been described in association with CDH. We made a molecular analysis through array comparative genomic hybridization (array CGH) of a grou.. Read More»
- Genet. Mol. Res. 10(1):
- vol10-1gmr1001
- DOI:
- 10.4238/vol10-1gmr1001
Ketamine used as an acesodyne in human breast cancer therapy causes an undesirable side effect, upregulating anti-apoptosis protein Bcl-2 expression
Authors: H. He, J. Chen, W.P. Xie, S. Cao, H.Y. Hu, L.Q. Yang and B. Gong
Ketamine is a dissociative anesthetic agent that has been widely used in surgery and for relieving pain in chronic cancer patients. We applied ketamine to breast cancer cell line MDA-MB-231 to detect the effect of treatment and molecular mechanisms involved. We found that ketamine can upregulate the level of anti-apoptosis protein Bcl-2, which promotes br.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.January.4.7
- DOI:
- 10.4238/2013.January.4.7