Mitochondrial ND3 G10398A mutation: a biomarker for breast cancer
Authors: Y. Yu, F. Lv, H. Lin, G. Qian, Y.S. Jiang, L.X. Pang, Y.P. Wang, X.F. Wang, Y.M. Kang, C.B. Li, Q. Liu, J.Z. Xu and W. You
Mitochondrial DNA mutations have been found to play important roles in carcinogenesis. The most common G10398A mutation, a non-conservative amino acid substitution from Thr to Ala, seems to be involved in the tumorigenesis of breast cancer. Results from studies concerning this mutation remain inconclusive. In the current study, we first took clinical and .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.21.12
- DOI:
- 10.4238/2015.December.21.12
Genetic polymorphisms of the FATP1 gene and their associations with meat quality traits in Chinese Qinchuan cattle
Authors: Z.D. Zhao, A.N. Li, S.J. Wei, M.M. Wang, S.J. Li and L.S. Zan
Fatty acid transport protein 1 (FATP1), an integral membrane protein that facilitates long-chain fatty acid influx, is involved in the genetic network for oleic acid synthesis. The aim of this study was to examine the association of FATP1 polymorphisms with live animal meat quality traits in Chinese Qinchuan cattle. Quantitative real-time PCR analysis dem.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.21.14
- DOI:
- 10.4238/2015.December.21.14
Effect of hypothalamic-pituitary-adrenal axis alterations on glucose and lipid metabolism in diabetic rats
Authors: M.W. Si, M.K. Yang and X.D. Fu
This study investigated the relationship between alterations in the hypothalamic-pituitary-adrenal (HPA) axis function and glucose and lipid metabolism in diabetic rats. To accomplish this a diabetes model was established by jointly administering a long-term high-fat diet plus Streptozotocin (STZ; 50 mg/kg ip). The rats were randomly divided into four gro.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.14.19
- DOI:
- 10.4238/2015.August.14.19
Identification of sorghum hybrids with high phenotypic stability using GGE biplot methodology
Authors: P.E. Teodoro, J.E. Almeida Filho, R.F. Daher, C.B. Menezes, M.J. Cardoso, V.P.C. Godinho, F.E. Torres and F.D. Tardin
The aim of this study was to identify sorghum hybrids that have both high yield and phenotypic stability in Brazilian environments. Seven trials were conducted between February and March 2011. The experimental design was a randomized complete block with 25 treatments and three replicates. The treatments consisted of 20 simple .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027914
- DOI:
- 10.4238/gmr.15027914
Association between IL-21 polymorphism and systemic lupus erythematosus: a meta-analysis
Authors: J.H. Qi, J. Qi, L.N. Xiang and G. Nie
Several case-control studies have been conducted to investigate the association between Interleukin-21 (IL-21) polymorphisms and systemic lupus erythematosus (SLE) susceptibility, and most of the studies focused on IL-21 rs907715 and rs2221903 polymorphisms. Given the inconsistent results from these studies, the present meta-analysis aimed to obtain a mor.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.14.22
- DOI:
- 10.4238/2015.August.14.22
Meta-analysis of the correlation between the TNF-�± 308G/A polymorphism and polycystic ovary syndrome
Authors: X.B. Liu, X.H. Deng, B. Zhou, L. Zhang and X.M. Niu
Previous studies have suggested that the tumor necrosis factor alpha (TNF-α) gene 308G/A polymorphism may be associated with polycystic ovary syndrome (PCOS) risk. However, this relationship is controversial. The present meta-analysis aimed to evaluate the correlation between the TNF-α308G/A polymorphism and suscep.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027923
- DOI:
- 10.4238/gmr.15027923
Blue-white screening liquid can eliminate false positives in blue-white colony screening
Authors: Y.S. Zhang
Although blue-white screening based on α-complementation has been widely used in the screening of genetically modified bacteria, only a single blue-white screening is typically not enough to eliminate false positives. Sometimes, a secondary blue-white screening for the target colonies is required. In this study, two meth.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027925
- DOI:
- 10.4238/gmr.15027925
Genetic diversity and structure of native and non-native populations of the endangered plant Pinus dabeshanensis
Authors: Z.Y. Zhang, H. Wang, W. Chen, X.M. Pang and Y.Y. Li
Owing to a severe decline in its abundance, Pinus dabeshanensis has been listed as an endangered species by the International Union for the Conservation of Nature. Although several restoration events have been undertaken since the 1960s, the natural population genetic structure of this species remains to be investigated. Herei.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027937
- DOI:
- 10.4238/gmr.15027937
Association between single nucleotide polymorphisms of X-ray repair cross-complementing protein 4 gene and development of pancreatic cancer
Authors: Y. Ding and L.N. Li
We performed a study to evaluate X-ray repair cross-complementing protein 4 (XRCC4) gene polymorphisms and the development of pancreatic cancer. A case-control study including 206 patients with newly diagnosed primary pancreatic cancer and 412 controls was performed between January 2011 and October 2013 in a Chinese population. Genotypes of XRCC4 rs180537.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.14.25
- DOI:
- 10.4238/2015.August.14.25
Association between matrix metallopeptidase 1 and type 2 diabetes mellitus coexisting with coronary heart disease in a Han Chinese population
Authors: Y.Z. Ma, Q.Y. Jiang and D.Q. Kong
Matrix metallopeptidase 1 (MMP-1) has been reported to be involved in the coexistence of type 2 diabetes mellitus (T2DM) and coronary heart disease (CHD). We sought to examine the association between the MMP-1 gene polymorphism and coexistence of T2DM and CHD in a Han Chinese population. We extracted genomic DNA from the perip.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027938
- DOI:
- 10.4238/gmr.15027938