In silico characterization of hypothetical proteins from Paracoccidioides lutzii
Authors: P.F.F. Silva, E. Novaes, M. Pereira, C.M.A. Soares, C.L. Borges and S.M. Salem-Izacc
Nearly 60% of Paracoccidioides lutzii genes encode products annotated as hypothetical or predicted proteins (HPs). In this study, we describe the global detection and functional inference of HPs, using computational methods based on sequence similarity, identification of targeting signals, presence of known protein domains, and use of the Gene Ontology fu.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.21.11
- DOI:
- 10.4238/2015.December.21.11
Mitochondrial tRNALeu(CUN) A12307G variant may not be associated pancreatic cancer
Authors: Y. Li, A.W. Huang, Y.Z. Chen, W.J. Yang, M.T. Zhou and H.W. Sun
Mitochondrial DNA mutations that lead to mitochondrial dysfunction have long been proposed to play important roles in the development of pancreatic cancer. Of these, alterations to mitochondrial tRNA genes constitute the largest group. Most recently, a variation at position 12307 in the gene encoding tRNALeu(CUN) has been repo.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027906
- DOI:
- 10.4238/gmr.15027906
Mitochondrial ND3 G10398A mutation: a biomarker for breast cancer
Authors: Y. Yu, F. Lv, H. Lin, G. Qian, Y.S. Jiang, L.X. Pang, Y.P. Wang, X.F. Wang, Y.M. Kang, C.B. Li, Q. Liu, J.Z. Xu and W. You
Mitochondrial DNA mutations have been found to play important roles in carcinogenesis. The most common G10398A mutation, a non-conservative amino acid substitution from Thr to Ala, seems to be involved in the tumorigenesis of breast cancer. Results from studies concerning this mutation remain inconclusive. In the current study, we first took clinical and .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.21.12
- DOI:
- 10.4238/2015.December.21.12
Genetic polymorphisms of the FATP1 gene and their associations with meat quality traits in Chinese Qinchuan cattle
Authors: Z.D. Zhao, A.N. Li, S.J. Wei, M.M. Wang, S.J. Li and L.S. Zan
Fatty acid transport protein 1 (FATP1), an integral membrane protein that facilitates long-chain fatty acid influx, is involved in the genetic network for oleic acid synthesis. The aim of this study was to examine the association of FATP1 polymorphisms with live animal meat quality traits in Chinese Qinchuan cattle. Quantitative real-time PCR analysis dem.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.21.14
- DOI:
- 10.4238/2015.December.21.14
Effect of hypothalamic-pituitary-adrenal axis alterations on glucose and lipid metabolism in diabetic rats
Authors: M.W. Si, M.K. Yang and X.D. Fu
This study investigated the relationship between alterations in the hypothalamic-pituitary-adrenal (HPA) axis function and glucose and lipid metabolism in diabetic rats. To accomplish this a diabetes model was established by jointly administering a long-term high-fat diet plus Streptozotocin (STZ; 50 mg/kg ip). The rats were randomly divided into four gro.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.14.19
- DOI:
- 10.4238/2015.August.14.19
Identification of sorghum hybrids with high phenotypic stability using GGE biplot methodology
Authors: P.E. Teodoro, J.E. Almeida Filho, R.F. Daher, C.B. Menezes, M.J. Cardoso, V.P.C. Godinho, F.E. Torres and F.D. Tardin
The aim of this study was to identify sorghum hybrids that have both high yield and phenotypic stability in Brazilian environments. Seven trials were conducted between February and March 2011. The experimental design was a randomized complete block with 25 treatments and three replicates. The treatments consisted of 20 simple .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027914
- DOI:
- 10.4238/gmr.15027914
Association between IL-21 polymorphism and systemic lupus erythematosus: a meta-analysis
Authors: J.H. Qi, J. Qi, L.N. Xiang and G. Nie
Several case-control studies have been conducted to investigate the association between Interleukin-21 (IL-21) polymorphisms and systemic lupus erythematosus (SLE) susceptibility, and most of the studies focused on IL-21 rs907715 and rs2221903 polymorphisms. Given the inconsistent results from these studies, the present meta-analysis aimed to obtain a mor.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.14.22
- DOI:
- 10.4238/2015.August.14.22
Meta-analysis of the correlation between the TNF-�± 308G/A polymorphism and polycystic ovary syndrome
Authors: X.B. Liu, X.H. Deng, B. Zhou, L. Zhang and X.M. Niu
Previous studies have suggested that the tumor necrosis factor alpha (TNF-α) gene 308G/A polymorphism may be associated with polycystic ovary syndrome (PCOS) risk. However, this relationship is controversial. The present meta-analysis aimed to evaluate the correlation between the TNF-α308G/A polymorphism and suscep.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027923
- DOI:
- 10.4238/gmr.15027923
Blue-white screening liquid can eliminate false positives in blue-white colony screening
Authors: Y.S. Zhang
Although blue-white screening based on α-complementation has been widely used in the screening of genetically modified bacteria, only a single blue-white screening is typically not enough to eliminate false positives. Sometimes, a secondary blue-white screening for the target colonies is required. In this study, two meth.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027925
- DOI:
- 10.4238/gmr.15027925
Genetic diversity and structure of native and non-native populations of the endangered plant Pinus dabeshanensis
Authors: Z.Y. Zhang, H. Wang, W. Chen, X.M. Pang and Y.Y. Li
Owing to a severe decline in its abundance, Pinus dabeshanensis has been listed as an endangered species by the International Union for the Conservation of Nature. Although several restoration events have been undertaken since the 1960s, the natural population genetic structure of this species remains to be investigated. Herei.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027937
- DOI:
- 10.4238/gmr.15027937