Epigallocatechin-3-gallate protects retinal vascular endothelial cells from high glucose stress in vitro via the MAPK/ERK-VEGF pathway
Authors: L. Zhang, Z.K. Zhang and S. Liang
Diabetic retinopathy (DR) is a frequent microvascular complication of diabetes, and one of the most common causes of legal blindness in the world. Epigallocatechin-3-gallate (EGCG) produces an anti-oxidative and anti-inflammatory effect against various human diseases. In this study, we determined the effect of EGCG on a human .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027874
- DOI:
- 10.4238/gmr.15027874
HPV infection-associated anogenital cyto-colpo-histological findings and molecular typing in HIV-positive women
Authors: F.K. Tso, C.L.L. Rodrigues, J.E. Levi, M.G. Mattosinho de Castro Ferraz, N.M.G. Speck and J.C.L. Ribalta
HIV and human papillomavirus (HPV) coinfection is increasing, especially in the anal canal (AC) and cervico-vaginal regions.We identified anal epithelium abnormalities related to high-risk HPV (HR-HPV) lesions in the lower genital tracts (LGTs) of HIV-positive women, described the HPV genotypes identified, and assessed the expression of E6/E7 oncogenes in.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.21.36
- DOI:
- 10.4238/2015.December.21.36
Efficient construction of recombinant adenovirus expression vector of the Qinchuan cattle LYRM1 gene
Authors: Y.K. Li, C.Z. Fu, Y.R. Zhang and L.S. Zan
In this study, we cloned the coding DNA sequence (CDS) region of Qinchuan cattle LYR motif-containing 1 (LYRM1) and constructed a recombinant adenovirus expression vector to examine the function of LYRM1 on the cellular level. Total RNA was extracted from the adipose tissue of Qinchuan cattle, cDNA was obtained by reverse transcription, and polymerase cha.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.14.10
- DOI:
- 10.4238/2015.August.14.10
Aquaporin in the proliferation and apoptosis of diabetic myocardial cells
Authors: P.F. Zhao and M.J. Sun
The aim of this study was to explore the effect of aquaporin on the molecular mechanism of human diabetic myocardial cell apoptosis. The methylthiazolyle tetrazolium assay was used to detect the inhibitory effect of different concentrations of aquaporin on cell growth. The rate of aquaporin-induced myocardial cell apoptosis was detected by flow cytometric.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.21.5
- DOI:
- 10.4238/2015.December.21.5
Molecular analysis and conventional cytology: association between HPV and bacterial vaginosis in the cervical abnormalities of a Brazilian population
Authors: A.L. Peres, J.R.S.L. Camarotti, M. Cartaxo, N. Alencar, R.C. Stocco, W. Be�§ak, N.T. Pontes-Filho, R.F.F. Ara�ºjo, J.L. Lima-Filho and D.B.G. Martins2
We investigated the association between bacterial vaginosis (BV) and human papillomavirus (HPV) infection in Papanicolaou smears in a Brazilian population. Cross-sectional analysis was performed on 673 samples collected from women attending public health centers in Olinda (PE, Brazil) by conventionalcytology methodology and molecular analysis, PCR tests (.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.14.13
- DOI:
- 10.4238/2015.August.14.13
CXCL12 G801A polymorphism and susceptibility to glioma: a case�control study
Authors: S.F. Chang, S.L. Li, B. Yang, K.M. Yao, R.H. Miao, G.F. Liang and K.M. Zhang
Previous studies have demonstrated that the CXCL12 G801A polymorphism is closely correlated with tumor susceptibility. In addition, the CXCL12/CXCR4 pathway is closely related to proliferation, metastasis, and invasion of glioma. However, the genetic effects of the CXCL12 G801A polymorphism on glioma risk in Chinese populations remain unknown. In this stu.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.21.9
- DOI:
- 10.4238/2015.December.21.9
Association between XPG gene polymorphisms and development of gastric cancer risk in a Chinese population
Authors: Y.B. Feng, D.Q. Fan, J. Yu and Y.K. Bie
We conducted a case-control study to investigate the role of three common single nucleotide polymorphisms (SNPs) in the xeroderma pigmentosum complementation group G (XPG) gene (rs2094258, rs751402 and rs17655) in the development of gastric cancer in a Chinese population. Between January 2012 and December 2014, samples from a .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027877
- DOI:
- 10.4238/gmr.15027877
Specialized features of the outer hair cell shapes in the cochlear fovea of bats
Authors: S.Q. Zhang, S.L. Li, H.L. Zhu and L.Y. Yan
In this study, we examined the specialized features of the outer hair cells (OHCs) and the stereocilium bundles of the bat cochlear fovea. Bat cochlea hair cells were observed by scanning and transmission electron microscopy, and the auditory brainstem response thresholds were assessed. The stereocilia bundles of the OHCs were extremely short. The OHC bod.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.14.16
- DOI:
- 10.4238/2015.August.14.16
In silico characterization of hypothetical proteins from Paracoccidioides lutzii
Authors: P.F.F. Silva, E. Novaes, M. Pereira, C.M.A. Soares, C.L. Borges and S.M. Salem-Izacc
Nearly 60% of Paracoccidioides lutzii genes encode products annotated as hypothetical or predicted proteins (HPs). In this study, we describe the global detection and functional inference of HPs, using computational methods based on sequence similarity, identification of targeting signals, presence of known protein domains, and use of the Gene Ontology fu.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.21.11
- DOI:
- 10.4238/2015.December.21.11
Mitochondrial tRNALeu(CUN) A12307G variant may not be associated pancreatic cancer
Authors: Y. Li, A.W. Huang, Y.Z. Chen, W.J. Yang, M.T. Zhou and H.W. Sun
Mitochondrial DNA mutations that lead to mitochondrial dysfunction have long been proposed to play important roles in the development of pancreatic cancer. Of these, alterations to mitochondrial tRNA genes constitute the largest group. Most recently, a variation at position 12307 in the gene encoding tRNALeu(CUN) has been repo.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027906
- DOI:
- 10.4238/gmr.15027906