Risk of colorectal cancer associated with the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in the Kashmiri population
Authors: A.S. Sameer, Z.A. Shah, S. Nissar, S. Mudassar and M.A. Siddiqi
Methylenetetrahydrofolate reductase (MTHFR) is a critical enzyme in folate metabolism and is involved in DNA synthesis, DNA repair and DNA methylation. The two common functional polymorphisms of MTHFR, 677 C→T and 1298 A→C, have been shown to impact various diseases, including cancer. The 677 C→T polymorphism ha.. Read More»
- Genet. Mol. Res. 10(2):
- vol10-2gmr1067
- DOI:
- 10.4238/vol10-2gmr1067
Method for obtaining high-resolution proteomic analysis from pericarps of guarana
Authors: A.L. Souza, P.C.S. Angelo, P.P.O. Nogueira, J.F.C. Gon�§alves, A.M. Franco, S. Astolfi-Filho, J.L. L�³pez-Lozano and E.V. Andrade
Guarana has great agricultural potential and is largely used therapeutically and in the production of non-alcoholic energy drinks. Genomic and proteomic studies are crucial to identify proteins that play central roles in the maintenance and viability of fruits, as well as to identify proteins related to the main metabolic path.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.29.14
- DOI:
- 10.4238/2014.September.29.14
Identification of novel DYNC2H1 mutations associated with short rib-polydactyly syndrome type III using next-generation panel sequencing
Authors: L.S. Chen, S.J. Shi, P.S. Zou, M. Ma, X.H. Chen and D.H. Cao
Short rib-polydactyly syndrome type III (SRPS3) is a perinatal lethal skeletal disorder with polydactyly and multisystem organ abnormalities. While ultrasound of the fetus can detect skeletal abnormalities characteristic of SRPS3, the syndrome is often difficult to diagnose before birth. As SRPS3 is an autosomal recessive diso.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028134
- DOI:
- 10.4238/gmr.15028134
Genetic diversity in wild sweet cherries (Prunus avium) in Turkey revealed by SSR markers
Authors: S. Ercisli, G. Agar, N. Yildirim, B. Duralija, A. Vokurka and H. Karlidag
Wild sweet cherry (Prunus avium) trees are abundant in the northern part of Turkey, including the Coruh Valley. We analyzed 18 wild sweet cherry genotypes collected from diverse environments in the upper Coruh Valley in Turkey to determine genetic variation, using 10 SSR primers. These SSR primers generated 46 alleles; the num.. Read More»
- Genet. Mol. Res. 10(2):
- vol10-2gmr1196
- DOI:
- 10.4238/vol10-2gmr1196
Genetic variability and resistance of cultivars of cowpea [Vigna unguiculata (L.) Walp] to cowpea weevil (Callosobruchus maculatus Fabr.)
Authors: M.X. Vila Nova , N.G.A. Leite , L.M. Houllo , L.V. Medeiros, A.C. Lira Neto , B.S. Hsie1, L.R. Borges-Paluch , B.S. Santos, C.S.F. Araujo, A.A. Rocha and A.F. Costa
The cowpea weevil (Callosobruchus maculatus Fabr.) is the most destructive pest of the cowpea bean; it reduces seed quality. To control this pest, resistance testing combined with genetic analysis using molecular markers has been widely applied in research. Among the markers that show reliable results, the inter-simple sequenc.. Read More»
- Genet. Mol. Res. 13(1):
- 2014.March.31.12
- DOI:
- 10.4238/2014.March.31.12
Matrix metalloproteinase-9 gene polymorphism in hepatocellular carcinoma patients with hepatitis B and C viruses
Authors: A. El Samanoudy, R. Monir, A. Badawy, L. Ibrahim, K. Farag, S. El Baz, D. Alenizi and A. Alenezy
Hepatocellular carcinoma (HCC) is the fifth most common malignancy worldwide. In Egypt, the incidence of HCC has doubled over the last decade. Matrix metalloproteinase-9 (MMP-9) plays a key role in cancer invasion and metastasis by degrading the extracellular matrix and basement membrane barriers. A cytosine (C)/thymidine (T) .. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.29.15
- DOI:
- 10.4238/2014.September.29.15
Meta-analysis of the IL-10 promoter polymorphisms and pediatric asthma susceptibility
Authors: Z.Y. Huang, B.J. Cheng, Y. Wan and C. Zhou
The results of previous epidemiological studies exploring the relationship between interleukin-10 (IL-10) promoter polymorphisms and susceptibility to pediatric asthma are not consistent. Therefore, we have performed a systematic review and meta-analysis to provide a more convincing conclusion. Odds ratios (OR) with their 95% .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028320
- DOI:
- 10.4238/gmr.15028320
Effect of dietary Bacillus subtilis on proportion of Bacteroidetes and Firmicutes in swine intestine and lipid metabolism
Authors: C. Cui, C.J. Shen, G. Jia and K.N. Wang
The ratio of Bacteroidetes and Firmicutes bacterial groups in the gut can affect the ability to absorb nutrients. We investigated the effect of probiotic Bacillus subtilis supplementation of diets on growth performance, fat deposition, blood lipids, copy numbers, and percentage of Bacteroidetes and Firmicutes in cecal contents, as well as mRNA expression .. Read More»
- Genet. Mol. Res. 12(2):
- 2013.May.23.1
- DOI:
- 10.4238/2013.May.23.1
Candidate gene region for control of rib eye area in Canchim beef cattle
Authors: S.L. Meirelles, G.V. Gouveia, G. Gasparin, M.M. Alencar, J.J.S. Gouveia and L.C.A. Regitano
Investigation of molecular marker effects on production traits is essential to define marker assisted selection strategies in beef cattle. We looked for a possible association of molecular markers and backfat thickness (BFT) and rib eye area (REA) in Canchim (5/8 Charolais + 3/8 Zebu) and MA (offspring of Charolais bulls and 1.. Read More»
- Genet. Mol. Res. 10(2):
- vol10-2gmr1175
- DOI:
- 10.4238/vol10-2gmr1175
Development of an improved rat model of dual graft liver transplantation with long-term survival
Authors: X.-J. Xie, Y.-F. Ye, Y. He, H.-Y. Xie, L. Zhou, Y. Wang, C.-Y. Xing and S.-S. Zheng
Dual graft liver transplantation has been demonstrated to be feasible as well as effective in increasing the donor pool and in preventing the potential for small-for-size syndrome. However, little is known about the pathophysiological and immune processes following dual graft liver transplantation due to the lack of appropriat.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.29.16
- DOI:
- 10.4238/2014.September.29.16