Active vitamin D3, 1,25-(OH)2D3, protects against macrovasculopathy in a rat model of type 2 diabetes mellitus
Authors: R. Ma, X.L. Deng, G.L. Du, C. Li, S. Xiao, Y. Aibibai and J. Zhu
To investigate the protective effect of the active form of vitamin D3, 1,25-(OH)2D3, on macrovasculopathy in rats with type 2 diabetes mellitus (T2DM), 8-week-old male Sprague-Dawley rats were randomly divided into control group, T2DM group, and treatment group. The T2DM model was established after 6 weeks by administering an .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028113
- DOI:
- 10.4238/gmr.15028113
Expression of ezrin and moesin related to invasion, metastasis and prognosis of laryngeal squamous cell carcinoma
Authors: X. Wang, M. Liu and C.Y. Zhao
We examined the expression of ezrin and moesin in laryngeal squamous cell carcinoma (LSCC) and their correlation with patient clinicopathological characteristics and overall survival. Immunohistochemical staining and reverse transcription-polymerase chain reaction (RT-PCR) for ezrin and moesin were applied to 60 carcinoma tissues, adjacent normal tissues,.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.29.13
- DOI:
- 10.4238/2014.September.29.13
Risk of colorectal cancer associated with the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in the Kashmiri population
Authors: A.S. Sameer, Z.A. Shah, S. Nissar, S. Mudassar and M.A. Siddiqi
Methylenetetrahydrofolate reductase (MTHFR) is a critical enzyme in folate metabolism and is involved in DNA synthesis, DNA repair and DNA methylation. The two common functional polymorphisms of MTHFR, 677 C→T and 1298 A→C, have been shown to impact various diseases, including cancer. The 677 C→T polymorphism ha.. Read More»
- Genet. Mol. Res. 10(2):
- vol10-2gmr1067
- DOI:
- 10.4238/vol10-2gmr1067
Method for obtaining high-resolution proteomic analysis from pericarps of guarana
Authors: A.L. Souza, P.C.S. Angelo, P.P.O. Nogueira, J.F.C. Gon�§alves, A.M. Franco, S. Astolfi-Filho, J.L. L�³pez-Lozano and E.V. Andrade
Guarana has great agricultural potential and is largely used therapeutically and in the production of non-alcoholic energy drinks. Genomic and proteomic studies are crucial to identify proteins that play central roles in the maintenance and viability of fruits, as well as to identify proteins related to the main metabolic path.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.29.14
- DOI:
- 10.4238/2014.September.29.14
Identification of novel DYNC2H1 mutations associated with short rib-polydactyly syndrome type III using next-generation panel sequencing
Authors: L.S. Chen, S.J. Shi, P.S. Zou, M. Ma, X.H. Chen and D.H. Cao
Short rib-polydactyly syndrome type III (SRPS3) is a perinatal lethal skeletal disorder with polydactyly and multisystem organ abnormalities. While ultrasound of the fetus can detect skeletal abnormalities characteristic of SRPS3, the syndrome is often difficult to diagnose before birth. As SRPS3 is an autosomal recessive diso.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028134
- DOI:
- 10.4238/gmr.15028134
Genetic diversity in wild sweet cherries (Prunus avium) in Turkey revealed by SSR markers
Authors: S. Ercisli, G. Agar, N. Yildirim, B. Duralija, A. Vokurka and H. Karlidag
Wild sweet cherry (Prunus avium) trees are abundant in the northern part of Turkey, including the Coruh Valley. We analyzed 18 wild sweet cherry genotypes collected from diverse environments in the upper Coruh Valley in Turkey to determine genetic variation, using 10 SSR primers. These SSR primers generated 46 alleles; the num.. Read More»
- Genet. Mol. Res. 10(2):
- vol10-2gmr1196
- DOI:
- 10.4238/vol10-2gmr1196
Genetic variability and resistance of cultivars of cowpea [Vigna unguiculata (L.) Walp] to cowpea weevil (Callosobruchus maculatus Fabr.)
Authors: M.X. Vila Nova , N.G.A. Leite , L.M. Houllo , L.V. Medeiros, A.C. Lira Neto , B.S. Hsie1, L.R. Borges-Paluch , B.S. Santos, C.S.F. Araujo, A.A. Rocha and A.F. Costa
The cowpea weevil (Callosobruchus maculatus Fabr.) is the most destructive pest of the cowpea bean; it reduces seed quality. To control this pest, resistance testing combined with genetic analysis using molecular markers has been widely applied in research. Among the markers that show reliable results, the inter-simple sequenc.. Read More»
- Genet. Mol. Res. 13(1):
- 2014.March.31.12
- DOI:
- 10.4238/2014.March.31.12
Matrix metalloproteinase-9 gene polymorphism in hepatocellular carcinoma patients with hepatitis B and C viruses
Authors: A. El Samanoudy, R. Monir, A. Badawy, L. Ibrahim, K. Farag, S. El Baz, D. Alenizi and A. Alenezy
Hepatocellular carcinoma (HCC) is the fifth most common malignancy worldwide. In Egypt, the incidence of HCC has doubled over the last decade. Matrix metalloproteinase-9 (MMP-9) plays a key role in cancer invasion and metastasis by degrading the extracellular matrix and basement membrane barriers. A cytosine (C)/thymidine (T) .. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.29.15
- DOI:
- 10.4238/2014.September.29.15
Meta-analysis of the IL-10 promoter polymorphisms and pediatric asthma susceptibility
Authors: Z.Y. Huang, B.J. Cheng, Y. Wan and C. Zhou
The results of previous epidemiological studies exploring the relationship between interleukin-10 (IL-10) promoter polymorphisms and susceptibility to pediatric asthma are not consistent. Therefore, we have performed a systematic review and meta-analysis to provide a more convincing conclusion. Odds ratios (OR) with their 95% .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028320
- DOI:
- 10.4238/gmr.15028320
Effect of dietary Bacillus subtilis on proportion of Bacteroidetes and Firmicutes in swine intestine and lipid metabolism
Authors: C. Cui, C.J. Shen, G. Jia and K.N. Wang
The ratio of Bacteroidetes and Firmicutes bacterial groups in the gut can affect the ability to absorb nutrients. We investigated the effect of probiotic Bacillus subtilis supplementation of diets on growth performance, fat deposition, blood lipids, copy numbers, and percentage of Bacteroidetes and Firmicutes in cecal contents, as well as mRNA expression .. Read More»
- Genet. Mol. Res. 12(2):
- 2013.May.23.1
- DOI:
- 10.4238/2013.May.23.1