Identification of robust adaptation gene regulatory network parameters using an improved particle swarm optimization algorithm
Authors: X.N. Huang and H.P. Ren
Robust adaptation is a critical ability of gene regulatory network (GRN) to survive in a fluctuating environment, which represents the system responding to an input stimulus rapidly and then returning to its pre-stimulus steady state timely. In this paper, the GRN is modeled using the Michaelis-Menten rate equations, which are.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028652
- DOI:
- 10.4238/gmr.15028652
Verification and characterization of chromosome duplication in haploid maize
Authors: E.G. de Oliveira Couto, E.V. Resende Von Pinho, R.G. Von Pinho, A.D. Veiga, M.R. de Carvalho, F. de Oliveira Bustamante and M.S. Nascimento
Doubled haploid technology has been used by various private companies. However, information regarding chromosome duplication methodologies, particularly those concerning techniques used to identify duplication in cells, is limited. Thus, we analyzed and characterized artificially doubled haploids using microsatellites molecular markers, pollen viability, .. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.26.9
- DOI:
- 10.4238/2015.June.26.9
Tetradecyl 2,3-dihydroxybenzoate promotes functional recovery after spinal cord injury in adult rats
Authors: Y.M. Ding, J.Y. Zhu, S.J. Zhang, S.S. Zhang, C. Wang, L.L. Wang and X. Zhang
Tetradecyl 2,3-dihydroxybenzoate (ABG001) is a small molecule separated from gentian extract that has a similar effect to nerve growth factor. It is not clear whether it can promote functional recovery in animals suffering from a central nervous system injury. In order to explore the role of ABG001 in restoration of tissue str.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028653
- DOI:
- 10.4238/gmr.15028653
Generic framework for mining cellular automata models on protein-folding simulations
Authors: N. Diaz and I. Tischer
Cellular automata model identification is an important way of building simplified simulation models. In this study, we describe a generic architectural framework to ease the development process of new metaheuristic-based algorithms for cellular automata model identification in protein-folding trajectories. Our framework was de.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028654
- DOI:
- 10.4238/gmr.15028654
IL-17A and IL-17F polymorphisms and gastric cancer risk: a meta-analysis
Authors: Z. Li, Y. Liu, D. Cao, M. Jiang and F. Luo
We conducted a meta-analysis of eligible studies to estimate the association between gastric cancer risk and rs2275913G>A IL-17A and rs763780T>C IL-17F polymorphisms. We searched the relevant studies in both Chinese and English through PubMed, the Web of Science, the Cochrane Library, and EMBASE up to January 1, 2014, including 3939 cases and 5407 c.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.26.10
- DOI:
- 10.4238/2015.June.26.10
Significance of Bcl10 gene mutations in the clinical diagnosis of MALT-type ocular adnexal lymphoma in the Chinese population
Authors: J. Zhu, R.L. Wei, Y.L. Pi and Q. Guo
We investigated the expression of Bcl10 gene mutations in mucosa-associated lymphoid tissue-type ocular adnexal lymphoma (OAL), atypical lymphoid hyperplasia (ALH), and reactive lymphoid hyperplasia (RLH) in the Chinese population and its role in clinical diagnosis and pathogenesis. Forty-three samples were collected during patient surgeries. Pathological.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.April.12.6
- DOI:
- 10.4238/2013.April.12.6
Construction of a cDNA library of the Chinese wild Vitis amurensis under cold stress and analysis of potential hardiness-related expressed sequence tags
Authors: J. Zhang, N. Liu, R. Niu, Y. Liu, H. Zhai, W. Xu and Y. Wang
A cDNA library of Chinese wild Vitis amurensis, which is the most cold-resistant species in the genus Vitis, was constructed using young leaves of seedlings of the clone Heilongjiang potted and subjected to cold stress. The leaves were harvested at various times after cold stress for total RNA extraction, which was used to generate expressed sequence tags.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.April.12.5
- DOI:
- 10.4238/2013.April.12.5
Fermented milk elaborated with Camellia sinensis
Authors: O.A.S. Ribeiro, M.I.A. Silva and C.A. Boari
This study aimed to develop and to characterize fermented dairy beverage formulated with Camellia sinensis. The infusion was elaborated with the addiction of dehydrated leaves of C. sinensis in whey (1g/100g) which added in sweetened milk (10% sucrose w/w) coagulated by Streptococcus salivarius subspecies thermophilus and Lact.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028686
- DOI:
- 10.4238/gmr.15028686
Comparative multiplex dosage analysis in spinocerebellar ataxia type 2 patients
Authors: F. Cal�¬, V. Chiavetta, A. Ragalmuto, M. Vinci, G. Ruggeri, P. Schinocca and V. Romano
We developed a new application of comparative multiplex dosage analysis (CMDA) for evaluation of the ataxin 2 gene. Expansions of the triplet CAG can cause spinocerebellar ataxia type 2 (SCA2), a neurodegenerative disease with an autosomal-dominant mode of inheritance. Molecular diagnosis of SCA2 is routinely based on the use of conventional PCR to detect.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.April.12.4
- DOI:
- 10.4238/2013.April.12.4
Mutational analyses of the TSC1 and TSC2 genes in cases of tuberous sclerosis complex in Chinese Han children
Authors: G.-X. Wang, D.-W. Wang, C.-Y. Yi, J.-S. Qu and Y.-L. Wang
Tuberous sclerosis complex (TSC) is an autosomal dominant neurogenetic disorder characterized by hamartomas in multiple organs and is caused by a wide spectrum of mutations in 1 of 2 causative genes (TSC1 or TSC2). Here, we present mutational analyses of the TSC1 and TSC2 genes in 4 cases of TSC in Chinese Han children, including 2 familial and 2 sporadic.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.April.12.3
- DOI:
- 10.4238/2013.April.12.3