Expression of human amyloid precursor protein in Drosophila melanogaster nerve cells causes a decrease in presynaptic gene mRNA levels
Authors: D.I. Rodin, A.L. Schwarzman and S.V. Sarantseva
Amyloid precursor protein (APP) is a key player in Alzheimer’s disease. The proteolytic cleavage of APP results in various short peptide fragments including the toxic amyloid-beta peptide, which is a main component of senile plaques. However, the functions of APP and its processed fragments are not yet well understood. Here, using real-time polymera.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.10.2
- DOI:
- 10.4238/2015.August.10.2
S-phase kinase-associated protein 2 expression interference inhibits breast cancer cell proliferation
Authors: Y.J. Sun, X.K. Wang and B.J. Li
We investigated the expression of S-phase kinase-associated protein 2 (SKP2) in breast cancer tissues, and the effects of SKP2-specific small interfering RNA (siRNA) interference on breast cancer cell proliferation. Thirty subjects provided breast cancer tissue samples and 18 subjects provided normal breast specimens for this study. The expression of SKP2.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.10.4
- DOI:
- 10.4238/2015.August.10.4
Genetic diversity and taxonomic status of Gymnocypris chilianensis based on the mitochondrial DNA cytochrome b gene
Authors: J.P. Zhang, Z. Liu, B. Zhang, X.Y. Yin, L. Wang, H.N. Shi and Y.J. Kang
In order to study the genetic diversity and taxonomic status of Gymnocypris chilianensis on a molecular level, the mitochondrial DNA cytochrome b gene was sequenced for 74 individuals of G. chilianensis from two locations (Heihe River and Shule River) and 42 individuals of its affinis species Gymnocypris przewalskii. Analyses of genetic diversity and sequ.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.10.5
- DOI:
- 10.4238/2015.August.10.5
Relationship of the APOA5/A4/C3/A1 gene cluster and APOB gene polymorphisms with dyslipidemia
Authors: H.J. Ou, G. Huang, W. Liu, X.L. Ma, Y. Wei, T. Zhou and Z.M. Pan
We determined the alleles of ten single nucleotide polymorphisms (SNPs) in the APOA5/A4/C3/A1 gene cluster and in APOB in Han Chinese from Xinjiang Shihezi, China using MALDI-TOF mass spectrometry, and explored the correlation between these SNPs and dyslipidemia through a case-control study design with 250 patients and 250 normal controls. All S.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.10.8
- DOI:
- 10.4238/2015.August.10.8
Correlation between protein 4.1R and the progression of heart failure in vivo
Authors: Z. Wei, G. Yang, R. Xu, C. Zhu, F. He, Q. Dou and J. Tang
We aimed to assess the protein 4.1R (4.1R) expression of the membrane skeleton in cardiomyocytes and to determine the potential role of 4.1R in the pathogenesis of heart failure (HF). Forty-two male mice were randomly divided into two groups: an HF group (N = 22) and control group (N = 20). The HF model was established by abdo.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028648
- DOI:
- 10.4238/gmr.15028648
WY14643 combined with all-trans retinoic acid acts via p38 MAPK to induce â??browningâ? of white adipocytes in mice
Authors: J. Wang, G.J. Sun, J. Ding, J.X. Zhang, Y. Cui, H.R. Li and S.J. Wang
The ability of mammals to resist body fat accumulation is linked to their ability to expand the number of “brown adipocytes” within white fat depots. All-trans retinoic acid (t-RA) and peroxisome proliferator-activated receptor-α (PPARα) have been implicated in “browning-like” or “browning” programs, respect.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.26.6
- DOI:
- 10.4238/2015.June.26.6
Protective effects of naringin against gp120-induced injury mediated by P2X7 receptors in BV2 microglial cells
Authors: Q. Chen, J. Hu, S.S. Qin, C.L. Liu, H. Wu, J.R. Wang, X.M. Lu, J. Wang, G.Q. Chen, Y. Liu, B.Y. Liu, C.S. Xu and S.D. Liang
This study was aimed at exploring the effects of P2X7 receptors on gp120-induced injury and naringin’s protective effects against gp120-induced injury in BV2 microglia. BV2 microglia injury model was established by gp120 treatment and MTS assay was used to verify whether naringin has a cell-protective effect against gp12.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028649
- DOI:
- 10.4238/gmr.15028649
Effects of conjugated linoleic acid on the expression levels of miR-27 and miR-143 inpig adipose tissue
Authors: R.L. Qi, Y. Chen, J.X. Huang andF.Y. Yang
In this study, we evaluated the effect and possible mechanism of action of dietary conjugated linoleic acid (CLA) on pig body fat deposition. Landrace piglets (N = 48) were randomly divided into three groups, which were fed diets containing 0% (control), 1%, or 2% CLA. Dorsal and abdominal subcutaneous adipose tissues were collected, and real-time polymer.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.26.7
- DOI:
- 10.4238/2015.June.26.7
Analysis of DNA equilibrium configuration under interfacial traction
Authors: Y.Z. Wang, Q.C. Zhang, W. Wang and Y.W. Yang
Kirchhoff thin elastic rod models are important in the study of the mechanism determining the configurations of flexible structures not only at the macroscopic but also at the microscopic scale. In this study, the energy balance method has been well applied to analyze the configuration of a DNA elastic rod in the presence of i.. Read More»
- Genet. Mol. Res. 15(2):
Expression profile of tumor suppressor gene RASSF1 in lacrimal gland carcinoma
Authors: C.H. Zeng, B. Guo, J. Chen, W.M. He and Q.L. Luo
We examined the expression pattern of the tumor suppressor gene RAS association domain family gene 1 (RASSF1) in lacrimal gland carcinoma and analyzed its relationship with the oncogenesis and progression of tumors. Sixty-two patients (30 males, 32 females, average age = 47 ± 3.5 years) admitted with lacrimal gland carcinoma to the Department of Op.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.26.8
- DOI:
- 10.4238/2015.June.26.8