Associations of single nucleotide polymorphisms in the Pygo2 coding sequence with idiopathic oligospermia and azoospermia
Authors: S.-Q. Ge, J. Grifin, L.-H. Liu, K.I. Aston, L. Simon, T.G. Jenkins, B.R. Emery and D.T. Carrell
Male infertility is often associated with a decreased sperm count. The Pygo2 gene is expressed in the elongating spermatid during chromatin remodeling; thus impairment in PYGO2 function might lead to spermatogenic arrest, sperm count reduction, and subsequent infertility. The aim of this study was to identify mutations in Pygo2 that might lead to idiopath.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.7.14
- DOI:
- 10.4238/2015.August.7.14
Diadenylate cyclase evaluation of ssDacA (SSU98_1483) in Streptococcus suis serotype 2
Authors: B. Du and J.H. Sun
Cyclic diadenosine monophosphate is a recently identified signaling molecule. It has been shown to play important roles in bacterial pathogenesis. SSU98_1483 (ssDacA), which is an ortholog of Listeria monocytogenes DacA, is a putative diadenylate cyclase in Streptococcus suis serotype 2. In this study, we determined the enzymatic activity of ssDacA in vit.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.18.34
- DOI:
- 10.4238/2015.June.18.34
Detection of Piwi-interacting RNAs based on sequence features
Authors: Y.J. Liu, J.Y. Zhang, A.M. Li, Z.W. Liu, Y.Y. Zhang and X.H. Sun
Piwi-interacting RNAs (piRNAs) are a class of small non-coding RNAs. Distinguishing piRNAs from other non-coding RNAs is important because of their important role in the physiological regulation of spermatogenesis, genome protection from transposons, and regulation of mRNAs and long non-coding RNAs. Few computational studies h.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028638
- DOI:
- 10.4238/gmr.15028638
Protective effects of morphine preconditioning in delayed phase on myocardial ischemia-reperfusion injury in rabbits
Authors: X.-H. Lu, K. Ran, Y.-Y. Xiao, D.-L. Yang, Y.-T. Chang, K.-M. Duan and Y.-W. Ou
The aim of this study was to investigate the protective mechanisms of delayed-phase morphine preconditioning on myocardial ischemia-reperfusion injury. Thirty healthy male New Zealand white rabbits were randomly divided into three groups: a sham operation group (C), ischemia-reperfusion group (I/R), and delayed-phase morphine preconditioning group (M) (N .. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.7.3
- DOI:
- 10.4238/2015.August.7.3
Effect of different time phases of radionuclide hepatobiliary scintigraphy on the differential diagnosis of congenital biliary atresia
Authors: Y.X. Guan,Q. Chen,S.H. Wan,J.S. Huang,X.Q. Yang L.J. Pan,Q.I. Zhang,Q. Zhang,Y.J. Ou,X.W. Peng,S.Z. Liu,Q.J. Chen and J. Lou
To investigate the value and essentiality of 6- and 24-h delay hepatobiliary scintigraphy in the differential diagnosis of biliary atresia (BA), we retrospectively analyzed 197 infants (121 boys/76 girls; age range, 3-205 days; average age, 63.9 days) admitted to Jiangxi Children’s Hospital for persistent jaundice (> 2 weeks), hepatosplenomegaly,.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.22.15
- DOI:
- http://dx.doi.org/10.4238/2015.April.22.15
Low diversity of the major histocompatibility complex class II DRA gene in domestic goats (Capra hircus) in Southern China
Authors: L.P. Chen, G.X. E, Y.J. Zhao, R.S. Na, Z.Q. Zhao, J.H. Zhang, Y.H. Ma, Y.W. Sun, T. Zhong, H.P. Zhang and Y.F. Huang
DRA encodes the alpha chain of the DR heterodimer, is closely linked to DRB and is considered almost monomorphic in major histocompatibility complex region. In this study, we identified the exon 2 of DRA to evaluate the immunogenetic diversity of Chinese south indigenous goat. Two single nucleotide polymorphisms in anuntranslated region and one synonymous.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.18.35
- DOI:
- 10.4238/2015.June.18.35
Development of novel polymorphic microsatellite markers for the blood clam Tegillarca granosa by pyrosequencing
Authors: Y.H. Dong, H.H. Yao, S.F. Shi, Y.B. Bao and Z.H. Lin
Large amounts of expressed sequence tags (ESTs) generated using next-generation sequencing technologies provide a cost-effective and valuable genomic resource for the development of microsatellite markers. In this study, we isolated 115 novel polymorphic microsatellite markers for the blood clam Tegillarca granosa from ESTs in 454 sequencing data. All the.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.7.6
- DOI:
- 10.4238/2015.August.7.6
Genetic polymorphisms and haplotype of hormone-related genes are associated with the risk of breast cancer in Chinese women
Authors: Z. Pan, Z. Fu, Q. Song, W. Cao, W. Cheng and X. Xu
Sex hormones play important roles in breast cancer (BC) development. This study investigated associations between BC risk and hormone-related gene variants in Chinese women. In a cohort of 336 patients with histopathologically confirmed BC and 390 age-matched controls, we genotyped seven single nucleotide polymorphisms (SNPs) .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028640
- DOI:
- 10.4238/gmr.15028640
Associations between the SRD5A2 gene V89L and TA repeat polymorphisms and breast cancer risk: a meta-analysis
Authors: D. Zhang, Q. Li, H.-C. Qu, T. Yu and Y.-R. Liu
The 5α-reductase type 2 (SRD5A2) gene plays a significant role in the development of breast cancer. The V89L and TA repeat polymorphisms of the SRD5A2 gene have been considered as risk factors for breast cancer. However, the results have been inconsistent. To resolve this conflict, we performed a meta-analysis of studies with V89L (1144 patients and.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.7.9
- DOI:
- 10.4238/2015.August.7.9
Decreased microRNA-143 expression and its tumor suppressive function in human oral squamous cell carcinoma
Authors: Z.Y. Ni, F.O. Lin, D.F. Liu and J. Xiao
MicroRNA-143 serves as a tumor suppressor in many human malignancies. However, its involvement in oral squamous cell carcinoma (OSCC) is still unclear. In this study, we investigated the effects of miR-143 in OSCC tumorigenesis and development. Using real-time quantitative reverse transcription-polymerase chain reaction, we detected miR-143 expression in .. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.26.2
- DOI:
- 10.4238/2015.June.26.2