Abstract

Low diversity of the major histocompatibility complex class II DRA gene in domestic goats (Capra hircus) in Southern China

Author(s): L.P. Chen, G.X. E, Y.J. Zhao, R.S. Na, Z.Q. Zhao, J.H. Zhang, Y.H. Ma, Y.W. Sun, T. Zhong, H.P. Zhang and Y.F. Huang

DRA encodes the alpha chain of the DR heterodimer, is closely linked to DRB and is considered almost monomorphic in major histocompatibility complex region. In this study, we identified the exon 2 of DRA to evaluate the immunogenetic diversity of Chinese south indigenous goat. Two single nucleotide polymorphisms in anuntranslated region and one synonymous substitution in coding region were identified. These data suggest that high immunodiversity in native Chinese population.

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