Association of -238G/A and -863C/A polymorphisms in the TNF-�± gene with chronic obstructive pulmonary disease based on a meta-analysis
Authors: K. Cui, X.Y. Ge and H.L. Ma
Chronic obstructive pulmonary disease (COPD) is a chronic systemic inflammatory disease; increasing evidence indicates that the TNF-α polymorphism is associated with progression of this disease. Few studies have focused upon association between TNF-α -238G/A or -863C/A polymorphism and COPD risk. Reported associations have been controversial b.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.October.24.10
- DOI:
- 10.4238/2013.October.24.10
Transient increase in IL-1�², IL-6 and TNF-�± gene expression in rat liver exposed to gold nanoparticles
Authors: H.A. Khan, M.A.K. Abdelhalim, A.S. Alhomida, M.S. Al Ayed
Most studies have used in vitro systems to test inflammatory responses of nanoparticles; these may not reflect the real biological response of body organs. In fact, certain nanoparticles have provoked opposite effects under in vitro and in vivo conditions. Current understanding of the biocompatibility of gold nanoparticles is .. Read More»
- Genet. Mol. Res. 12(4):
- 2013.November.22.12
- DOI:
- 10.4238/2013.November.22.12
Genetic diversity of the Chinese traditional herb Blumea balsamifera (Asteraceae) based on AFLP markers
Authors: Y.X. Pang, W.Q. Wang, Y.B. Zhang, Y. Yuan, J.B. Yu, M. Zhu and Y.Y. Chen
Blumea balsamifera is a commercially important medicinal herb in China and other parts of Asia. It is used to produce borneol. This plant grows in the wild, but resources have diminished greatly in recent years. We examined the genetic diversity of this species to help develop conservation strategies; 35 plants from five provi.. Read More»
- Genet. Mol. Res. 13(2):
- 2014.April.14.1
- DOI:
- 10.4238/2014.April.14.1
Genetic contribution of CYP2C9, CYP2C19, and APOE variants in acenocoumarol response
Authors: J.A. Nastasi-Catanese1, J.R. Padilla-Guti�©rrez2, Y. Valle2, F. Ortega-Guti�©rrez3, M.P. Gallegos-Arreola4 and L.E. Figuera5,6
Oral anticoagulants of the coumarin type have an inconveniently narrow therapeutic window, making their use difficult. In Mexico, genetic variables that participate in the heterogeneity of the therapeutic response remain poorly investigated. With the focus on warfarin, extensive pharmacogenomic studies have been performed, including those on the CYP450 fa.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.October.10.7
- DOI:
- 10.4238/2013.October.10.7
Association of polymorphisms of the xeroderma pigmentosum complementation group F gene with increased glioma risk
Authors: W.K. Zhou, L.Y. Huang, L. Hui, Z.W. Wang, B.Z. Jin, X.L. Zhao, X.Z. Zhang, J.X. Wang, J.C. Wang and R.Z. Wang
We aimed to investigate the role of 4 single nucleotide polymorphisms of the xeroderma pigmentosum complementation group F (XPF) gene (rs3136038, rs1799798, rs1800067, and rs2276466) in glioma, and the roles of gene-gene interactions in the risk of developing this type of cancer. We collected samples from 225 glioma cases and .. Read More»
- Genet. Mol. Res. 13(2):
- http://dx.doi.org/2014.May.16.7
- DOI:
- http://dx.doi.org/10.4238/2014.May.16.7
Keloid microRNA expression analysis and the influence of miR-199a-5p on the proliferation of keloid fibroblasts
Authors: Z.-Y. Wu, L. Lu, J. Liang, X.-R. Guo, P.H. Zhang and S.-J. Luo
The purpose of this study was to identify microRNAs (miRNAs) involved in keloid formation and determine their influence on the proliferation of keloid fibroblasts (KFs). Eight specimens each of resected keloid tissue and normal skin tissue were collected. miRNAs that are differentially expressed in keloid tissue and normal ski.. Read More»
- Genet. Mol. Res. 13(2):
- 2014.April.14.2
- DOI:
- 10.4238/2014.April.14.2
Expression of multidrug resistance 1 and multidrug resistance-related protein 1 in C57BL/6 mice treated with benzene
Authors: J.-S. Huang, M.-D. Zhao, J.-M. Shi, J.-H. Zhang, B. Li, W. Fan, Y.-L. Zhou
ATP-binding cassette super family (ABC) proteins are considered key to oncology and pharmacology studies. We examined the effect of benzene on ABC pump protein levels in C57BL/6 mouse bone marrow mononuclear cells. After a 2-week gavage (200 mg/kg, 5 days per week), the number of peripheral leukocytes, lymphocytes and basophil.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.November.22.11
- DOI:
- 10.4238/2013.November.22.11
Complete mitochondrial genome sequence of Marmota himalayana (Rodentia: Sciuridae) and phylogenetic analysis within Rodentia
Authors: Q.J. Chao, Y.D. Li, X.X. Geng, L. Zhang, X. Dai, X. Zhang, J. Li and H.J. Zhang
This is the first report of a complete mitochondrial genome sequence from Himalayan marmot (Marmota himalayana, class Marmota). We determined the M. himalayana mitochondrial (mt) genome sequence by using long-PCR methods and a primer-walking sequencing strategy with genus-specific primers. The complete mt genome of M. himalaya.. Read More»
- Genet. Mol. Res. 13(2):
- 2014.April.14.3
- DOI:
- 10.4238/2014.April.14.3
Male infertility in Northeast China: molecular detection of Y chromosome microdeletions in azoospermic patients with Klinefelter�s syndrome
Authors: H.-G. Zhang, Z.-B. Zhang, R.-X. Wang, Y. Yu, X.-W. Yu, E. Fadlalla and R.-Z. Liu
The prevalence of microdeletions of azoospermia factor (AZF) among azoospermic Klinefelter’s syndrome (KFS) patients shows conflicting data. We aimed to detect this frequency in a Northeast Chinese population, and to investigate the possible association between AZF microdeletions and KFS by comparison with previous conflicting reports. Eighty men af.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.October.24.9
- DOI:
- 10.4238/2013.October.24.9
Effect of RNAi-mediated silencing of Livin gene on biological properties of colon cancer cell line LoVo
Authors: A.M. Zou, H.F. Wang, W.F. Zhu, F.X. Wang and J.J. Shen
This study aimed to investigate the effect of RNAi-mediated silencing of the Livin gene on biological properties of the colon cancer cell line LoVo. Interference vectors pSilencer4.1-Ll and pSilencer4.1-L2 targeting the Livin gene were constructed and transfected into LoVo cells. The expression of the Livin gene was determined.. Read More»
- Genet. Mol. Res. 13(2):
- http://dx.doi.org/2014.May.16.8
- DOI:
- http://dx.doi.org/10.4238/2014.May.16.8