Molecular epidemiology of HFE gene polymorphic variants (C282Y, H63D and S65C) in the population of EspÃ?Ârito Santo, Brazil
Authors: L.N.R. Alves, E.V.W. Santos, E. Stur, A.M.A. Silva Conforti and I.D. Louro
Hereditary hemochromatosis (HH) is an autosomal recessive disorder that leads to progressive iron accumulation and may cause cirrhosis, hepatocellular carcinoma, diabetes, and heart failure. Most cases of HH have been linked to mutations in genes associated with iron homeostasis. There have been three major variants in the hig.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028189
- DOI:
- 10.4238/gmr.15028189
Improvement of a popcorn population using selection indexes from a fourth cycle of recurrent selection program carried out in two different environments
Authors: A.T. Amaral J�ºnior, S.P. Freitas J�ºnior, R.M. Rangel, G.F. Pena, R.M. Ribeiro, R.C. Morais and A.R. Schuelter
We estimated genetic gains for popcorn varieties using selection indexes in a fourth cycle of intrapopulation recurrent selection developed in the campus of the Universidade Estadual do Norte Fluminense. Two hundred full-sib families were obtained from the popcorn population UNB-2U of the third recurrent selection cycle. The p.. Read More»
- Genet. Mol. Res. 9(1):
- vol9-1gmr702
- DOI:
- 10.4238/vol9-1gmr702
Adaptability and phenotypic stability of common bean genotypes through Bayesian inference
Authors: A.M. Corr�ªa, P.E. Teodoro, M.C. Gon�§alves, L.M.A. Barroso,M. Nascimento, A. Santos and F.E. Torres
This study used Bayesian inference to investigate the genotype x environment interaction in common bean grown in Mato Grosso do Sul State, and it also evaluated the efficiency of using informative and minimally informative a priori distributions. Six trials were conducted in randomized blocks, and the grain yield of 13 common .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028260
- DOI:
- 10.4238/gmr.15028260
Lack of association between paraoxonase-1 Q192R polymorphism and rheumatoid arthritis in southeast Iran
Authors: M. Hashemi, A.K. Moazeni-Roodi, A. Fazaeli, M. Sandoughi, G.R. Bardestani, D.M. Kordi-Tamandani and S. Ghavami
Decreased paraoxonase-1 (PON1) activity has been associated with rheumatoid arthritis. There are two polymorphisms in serum PON1; one differs in the amino acid at position 192 (Q192R) and the other one differs at position 55 (L55M). We looked for a possible association between Q192R polymorphism and rheumatoid arthritis. The Q.. Read More»
- Genet. Mol. Res. 9(1):
- vol9-1gmr728
- DOI:
- 10.4238/vol9-1gmr728
Exploration of association between EPHX1 and chronic obstructive pulmonary disease on the basis of combined data mining
Authors: L. An, H. Xia, P. Zhou and L. Hua
Chronic obstructive pulmonary disease (COPD) is an important respiratory disease with high mortality. Although smoking is the major environmental risk factor for the development of COPD, only 10% of heavy smokers develop symptomatic disease, suggesting association between genetic susceptibilities and environmental influences. .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028639
- DOI:
- 10.4238/gmr.15028639
SSR-based molecular analysis of economically important Turkish apricot cultivars
Authors: A.E. Akp�±nar, H. Ko�§al, A. Erg�¼l, K. Kazan, M.E. ��elli, M. Bak�±r, ��. Aslanta��, S. Kaymak and R. Sar�±ba��
Turkey is not only the main apricot (Prunus armeniaca) producer and exporter in the world, but it also has a wide variety of apricot germplasms, owing to its close proximity to the centers of apricot origin. However, there is little or no genetic information on many apricot cultivars that are extensively cultivated in Turkey. .. Read More»
- Genet. Mol. Res. 9(1):
- vol9-1gmr727
- DOI:
- 10.4238/vol9-1gmr727
A discrete artificial bee colony algorithm for detecting transcription factor binding sites in DNA sequences
Authors: D. Karaboga and S. Aslan
The great majority of biological sequences share significant similarity with other sequences as a result of evolutionary processes, and identifying these sequence similarities is one of the most challenging problems in bioinformatics. In this paper, we present a discrete artificial bee colony (ABC) algorithm, which is inspired.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028645
- DOI:
- 10.4238/gmr.15028645
VP6 gene diversity in Brazilian strains of porcine group C rotavirus
Authors: K.C. M�©dici, A.F. Barry, A.F. Alfieri and A.A. Alfieri
Group C rotavirus (RV-C) has been found in Brazilian pig herds; however, wild-type strains have not yet been characterized. We made a molecular analysis of a region of gene 5 in Brazilian RV-C strains. Stool samples from 11 piglets (diarrheic and with normal consistency) positive for the RV-C VP6 gene in an RT-PCR assay were s.. Read More»
- Genet. Mol. Res. 9(1):
- vol9-1gmr715
- DOI:
- 10.4238/vol9-1gmr715
Identification of disturbed pathways in heart failure based on Gibbs sampling and pathway enrichment analysis
Authors: P. Chen, L.H. Guo, Y.K. Guo, Z.J. Qu, Y. Gao and H. Qiu
We identified disturbed pathways in heart failure (HF) based on Gibbs sampling combined with pathway enrichment analysis. A total of 396 Markov chains (MCs) (gene count >5) were obtained. After Gibbs sampling, six differentially expressed molecular functions (DEMFs) (possibility ≥0.8) were obtained. As statistical analys.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027956
- DOI:
- 10.4238/gmr.15027956
Jasmonates are phytohormones with multiple functions, including plant defense and reproduction
Authors: N.C. Avanci, D.D. Luche, G.H. Goldman and M.H.S. Goldman
The plant hormones jasmonic acid and methyl jasmonate, along with their intermediate compounds, produced in the octadecanoid pathway, are important signaling molecules that are collectively called jasmonates. These are widespread in the plant kingdom and play crucial roles in biotic/abiotic stress responses, as well as in proc.. Read More»
- Genet. Mol. Res. 9(1):
- vol9-1gmr754
- DOI:
- 10.4238/vol9-1gmr754