Effects of Maytenus ilicifolia on reproduction and embryo-fetal development in Wistar rats
Authors: A.L. Cunha-Laura, S.A. Auharek, R.J. Oliveira, J.M. Siqueira, M.C. Vieira, V.S. Leite and L.C. Portugal
Maytenus ilicifolia (Celastraceae), popularly known as espinheira-santa, is a native plant from the Atlantic forest and is commonly used in popular medicine to treat inflammation and as an abortifacient. To evaluate the effects of M. ilicifolia on pregnant rats during the organogenic period (T1) or throughout the gestational p.. Read More»
- Genet. Mol. Res. 13(2):
- http://dx.doi.org/2014.May.9.16
- DOI:
- http://dx.doi.org/10.4238/2014.May.9.16
Molecular characterization of the pseudorabies virus UL2 gene
Authors: M.S. Cai1,2, B.Y. Wang2, W. Cui1, Z.Y. Zhao1, J.H. Chen2, X.M. Wen1, Z. Li1 and M.L. Li1
A 948-bp sequence of the UL2 gene was amplified from the pseudorabies virus (PRV) Becker strain genome using polymerase chain reaction, and the gene identity was confirmed through further cloning and sequencing. Bioinformatic analysis indicated that the PRV UL2 gene encodes a putative polypeptide with 315-amino acid residues. Its encoding protein, designa.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.October.7.1
- DOI:
- 10.4238/2013.October.7.1
Effect of the Jianpi Bushen Prescription on expressions of the Wnt3a and Cyclin D1 genes in radiation-damaged mice
Authors: D.C. He*, J.J. Xiao*, Y. Zhang, H. Lin, X.J. Ding and Y. Tu
The effects of the traditional Chinese drug Jianpi Bushen Prescription (JBP) were investigated on expressions of Wnt3a and Cyclin D1 genes in radiation-damaged mice. The radiation damage model was induced in Kumming mice by single total body irradiation treatment for 9 days. Mice were divided into the radiation group, low-dose (100%) JBP group, high-dose .. Read More»
- Genet. Mol. Res. 12(4):
- 2013.October.3.1
- DOI:
- 10.4238/2013.October.3.1
Different impact of two mutations of a novel compound heterozygous protein C deficiency with late onset thrombosis
Authors: L.-H. Yang, M.-S. Wang, F.-X. Zheng, J. Li , Y. Chen, Y.-H. Jin, H.-X. Xie, X.-L. Yang and B.-C. Chen
We investigated the alteration of coagulation state in a protein C (PC) deficiency pedigree and the impact of the PC gene mutations. The pedigree of a proband with cerebral hemorrhagic infarction had sixteen members with four generations. The plasma levels of PC activity (PC:A), protein S activity (PS:A), factor V:C and factor VIII:C, and routine coagulat.. Read More»
- Genet. Mol. Res. 13(2):
- 2014.April.16.5
- DOI:
- 10.4238/2014.April.16.5
Apoptotic effects of proteasome and histone deacetylase inhibitors in prostate cancer cell lines
Authors: I. Kiliccioglu, E. Konac, N. Varol, S. Gurocak and C. Yucel Bilen
Prostate cancer is one of the most common types of urological cancers. Despite the implementation of effective radiotherapy and chemotherapy methods, prostate cancer cells can still show resistance to treatment. In recent years, a combination of proteasome and histone deacetylase inhibitors has been used to treat various malig.. Read More»
- Genet. Mol. Res. 13(2):
- http://dx.doi.org/2014.May.9.17
- DOI:
- http://dx.doi.org/10.4238/2014.May.9.17
Screening of the residual normal ovarian tissue adjacent to orthotopic epithelial ovarian carcinomas in nude mice
Authors: G.H. Zhu, S.T. Wang, M.Z. Yao, J.H. Cai, C.Y. Chen, Z.X. Yang, L. Hong and S.Y. Yang
The objective of this study was to explore the feasibility and methods of screening the residual normal ovarian tissue adjacent to orthotopic ovarian carcinomas in nude mice. Human epithelial ovarian cancer cells (OVCAR3) were subcutaneously implanted for a tumor source and ovarian orthotopic transplantation. The cancer tissue.. Read More»
- Genet. Mol. Res. 13(2):
- 2014.April.16.6
- DOI:
- 10.4238/2014.April.16.6
Correlation of growth-related traits and their effects on body weight of the mud crab (Scylla paramamosain)
Authors: H.Y. Ma, C.Y. Ma, L.B. Ma, Z. Xu, N.N. Feng and Z.G. Qiao
In this study, we analyzed the correlation of 20 growth-related traits and their effects on body weight of Scylla paramamosain. The correlation coefficients in all trait pairs were significantly high, ranging from 0.551 to 0.999. Among 19 X-Y pairs, the correlation coefficient between traits X1 and Y was the highest, whereas that between X13 and Y was the.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.October.1.3
- DOI:
- 10.4238/2013.October.1.3
Expression analysis of Gli1 and Gli2 in different tissues and muscle-derived cells of Qinchuan cattle
Authors: Y. Liu, H. Wang, G. Cheng B. Jiang and L. Zan
The Hedgehog (Hh) signaling pathway regulates the differentiation of many kinds of cells and plays a critical role in many embryonic and postnatal developmental processes. Gli1 and Gli2 are two transcription factors of the Hh signaling pathway. In this study, we used quantitative real-time polymerase chain reaction to detect the relative expression of Gli.. Read More»
- Genet. Mol. Res. 13(4):
Development of EST-SSR markers related to salt tolerance and their application in genetic diversity and evolution analysis in Gossypium
Authors: B.H. Wang, P. Zhu, Y.L. Yuan, C.B. Wang, C.M. Yu, H.H. Zhang, X.Y. Zhu, W. Wang, C.B. Yao, Z.M. Zhuang and P. Li
Salt stress is becoming one of the major problems in global agriculture with the onset of global warming, an increasing scarcity of fresh water, and improper land irrigation and fertilization practices, which leads to reduction of crop output and even causes crop death. To speed up the exploitation of saline land, it is a good.. Read More»
- Genet. Mol. Res. 13(2):
- http://dx.doi.org/2014.May.13.1
- DOI:
- http://dx.doi.org/10.4238/2014.May.13.1
�±-1,3-N-acetylgalactose aminotransferase gene 539G>C mutation leads to the A2B isoform
Authors: J.J. Lin, X.D. Wang and S.Y. Zhu
In this study, the phenotypic identification and molecular mechanism of one case of an A2B subtype pedigree was investigated. ABO blood groupings were identified by serological methods and sequence amplification was performed by polymerase chain reaction (PCR) using TA cloning and DNA sequencing analysis to identify the pedigr.. Read More»
- Genet. Mol. Res. 13(2):
- 2014.April.16.7
- DOI:
- 10.4238/2014.April.16.7