Association of IL-1�± gene polymorphism with susceptibility to type 1 diabetes in Chinese children
Authors: X. Zhou, J.G. Ca, H. Peng, J.L. Wang and G.M. Li
The interleukin-1α (IL-1α) gene appears to play a role in the pathogenesis of type 1 diabetes (T1D). Therefore, the aim of this study was to investigate the contribution of the IL-1 rs1800587 gene polymorphism to susceptibility to T1D in Chinese children. This case-control study included 332 Chinese children with T1D and 332 healthy controls. .. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038025
- DOI:
- 10.4238/gmr.15038025
Activation of Src tyrosine kinase in esophageal carcinoma cells in different regulatory environments and corresponding occurrence mechanism
Authors: Z.S. Yu, X.H. Song, H.M. Gan, D.Z. Geng and J. Yang
This study aims at observing the expression of activated Src tyrosine kinase in esophageal squamous cell carcinoma (ESCC), and exploring the relationship of Src tyrosine kinase with the occurrence and progression of ESCC. Immunohistochemistry, immunofluorescence, and immunoblotting are employed to investigate the expression of Src tyrosine kinase in the E.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038026
- DOI:
- 10.4238/gmr.15038026
Dynamic QTL analysis of seed reserve utilization in sh2 sweet corn germination stages
Authors: X.X. Cheng, S. He1 and G.H. Geng
In this study, dynamic quantitative trait loci (QTL) were mapped in a recombinant inbred line (F2:4) population derived from a BF3109 x Q267 cross. This was done during the unconditional (4, 7, and 10 days) and conditional (0 to 4, 4 to 7, and 7 to 10 days) germination stages in sh2 sweet corn. The values of seedling dry weight, weight of mobilized seed r.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038183
- DOI:
- 10.4238/gmr.15038183
Characterization of gene methylation in human papillomavirus associated-head and neck squamous cell carcinoma
Authors: H.Z. Zhang, C.G. Shan, A.P. Huang and J.M. Wang
Head and neck squamous cell carcinoma (HNSCC) has become one of the most common forms of cancer worldwide. Hypermethylation-induced silencing of tumor-associated gene has been proposed as an important cofactor in cancer pathology. This paper aimed to characterize the gene methylation patterns in human papillomavirus (HPV) associated-HNSCC. TIMP3 and APC m.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038206
- DOI:
- 10.4238/gmr.15038206
HLA-G genetic variants and hepatocellular carcinoma: a meta-analysis
Authors: A.V.C. Coelho, R.R. Moura, S. Crovella and F. Celsi
Human leukocyte antigen (HLA)-G is a key tolerogenic molecule mainly expressed in the placenta and is crucial for implantation of the embryo and immunological tolerance of the fetus during pregnancy. However, under pathological conditions, such as cancer or viral infections, HLA-G can be expressed in other tissues. The gene coding for HLA-G (HLA-G, chromo.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038263
- DOI:
- 10.4238/gmr.15038263
Investigation of the role of XRCC1 genetic polymorphisms in the development of gliomas in a Chinese population
Authors: S.C. Fan, J.G. Zhou and J.Z. Yin
We conducted a study in a Chinese Han population to investigate the role of XRCC1 gene polymorphisms (Arg399Gln and Arg194Trp) with a risk of susceptibility to gliomas. Samples from 115 patients with gliomas and 228 control subjects were consecutively collected between March 2012 and December 2014. Genotype analysis of XRCC1 Arg399Gln and Arg194Trp was pe.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038268
- DOI:
- 10.4238/gmr.15038268
Correlation of VCAM-1 expression in serum, cord blood, and placental tissue with gestational hypertension associated with fetal growth restriction in women from Xingtai Hebei, China
Authors: H.G. Zhang, W. Guo, H.F. Gu, S.B. Chen, J.Q. Wang, Z.X. Qiao, H.S. Ma and S.X. Geng
The aim of this study was to investigate the expression of vascular adhesion molecule (VCAM)-1 in the maternal serum, cord blood, and placental tissue of pregnant women from Xingtai, Hebei, with gestational hypertension (GH) combined with fetal growth restriction (FGR). A total of 108 patients with GH combined with FGR (GH-FGR), 60 patients with GH alone .. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038274
- DOI:
- 10.4238/gmr.15038274
Identification of key biomarkers involved in osteosarcoma using altered modules
Authors: Z.Z. Liu, S.T. Cui, B. Tang, Z.Z. Wang and Z.X. Luan
The aim of this study was to screen for key biomarkers of osteosarcoma (OS) by tracking altered modules. Protein-protein interaction (PPI) networks of OS and normal groups were constructed and re-weighted using the Pearson correlation coefficient (PCC), respectively. The condition-specific modules were explored from OS and normal PPI networks using a cliq.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038277
- DOI:
- 10.4238/gmr.15038277
Assessing the association between EFEMP1 rs3791679 polymorphism and risk of glioma in a Chinese Han population
Authors: N. Jiang, Y.P. Peng, X.Y. Wang, C.W. Dou and W.M. He
In this study, we assessed the association between the EFEMP1 rs3791679 polymorphism and glioma risk in a Chinese Han population. A total of 94 glioma patients and 206 healthy controls who conformed to the inclusion and exclusion criteria were recruited from Baogang Hospital between March 2012 and October 2014. The EFEMP1 rs3791679 gene polymorphism was a.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038279
- DOI:
- 10.4238/gmr.15038279
New chromosomal evidence for the origin of Triatoma infestans populations from Brazil
Authors: N.P. Pereira, K.C.C. Alevi, J.A. Rosa and M.T.V. Azeredo-Oliveira
In this study, the karyometry of different Triatoma infestans populations from different states of Brazil was analyzed and compared with those of a population from Cochabamba. No significant differences were found between the population from Cochabamba and those from Brazil. These results are consistent with the origin of the T. infestans populations of B.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038303
- DOI:
- 10.4238/gmr.15038303