Low levels of serum miR-99a is a predictor of poor prognosis in breast cancer
Authors: J. Li, Z.J. Song, Y.Y. Wang, Y. Yin, Y. Liu and X. Nan
MicroRNA (miRNA) deregulation has been previously linked to the initiation and development of breast cancer. Although miR-99a is aberrantly expressed in many types of cancers, including breast cancer, the serum miR-99a expression level in breast cancer and its clinical significance remains unknown. Blood samples were obtained from 72 patients with breast .. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038338
- DOI:
- 10.4238/gmr.15038338
Investigation on ERCC5 genetic polymorphisms and the development of gastric cancer in a Chinese population
Authors: L.Q. Yang, Y. Zhang and H.F. Sun
Our study aimed to investigate the role of 2 ERCC5 promoter SNPs (rs2094258 and rs751402) in the development of gastric cancer in the Chinese population. The present hospital-based case-control study consisted of 155 patients with gastric cancer and 246 healthy controls recruited between March 2012 and December 2014. Genotyping for the rs2094258 and rs751.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038364
- DOI:
- 10.4238/gmr.15038364
Development and significance of SCAR marker QG12-5 for Canarium album (Lour.) Raeusch by molecular cloning from improved RAPD amplification
Authors: J.L. Cheng, Z.C. Yin Z.Q. Mei, C.L. Wei, H.C. Chen, X.S. Wu and J.J. Fu
Sequence-characterized amplified region (SCAR) is a valuable molecular marker for the genetic identification of any species.This marker is mainly derived from molecular cloning of random amplified polymorphic DNA (RAPD). We have previously reported the use of an improved RAPD technique for the genetic characterization of different samples of Canarium albu.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038347
- DOI:
- 10.4238/gmr.15038347
Association of CYP1A1 (cytochrome P450) MspI polymorphism in women with endometriosis
Authors: A.M. Barbosa, S.R. de Souza,, A.B. Frare, R.C. Costa e Silva, I.R. da Costa, K.S. Freitas e Silva, C.L. Ribeiro J�ºnior, B.M. Bordin and K.K.V.O. Moura
Endometriosis is a disease that affects 10 to 15% of the women of reproductive age. It is characterized by the presence of endometrial-like tissues outside of the uterus. Some definitions claim that the functional ectopic tissue is sensitive to the action of hormones. Severity of endometriosis is defined according to a system proposed by the American Soci.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038389
- DOI:
- 10.4238/gmr.15038389
Gene expression profiling analysis of 5-hydroxytryptamine signaling pathway in rat regenerating liver and different types of liver cells
Authors: C.F. Chang, J. Yang, W.M. Zhao, Y. Li, P.J. Guo, M.H. Li, Y. Zhou and C.S. Xu
We examined the gene expression profiles of the 5-hydroxytryptamine signaling pathway in the regenerating liver and 8 types of liver cells during rat liver regeneration, and explored expression differences in 5-hydroxytryptamine signaling pathway genes at the level of tissues and cells, as well as the role of the pathway on liver regeneration. Eight types.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.15.4
- DOI:
- http://dx.doi.org/10.4238/2015.April.15.4
Association of the genes for tumor necrosis factor-�± and myelin basic protein with delayed encephalopathy after acute carbon monoxide poisoning
Authors: S.G. Li W.Q. Li J.K. Wang H.Y. Zhang W. Li P. Zhang X.H. Wang H.X. Zhang J.P. Gu R.J. Gu
There is structural damage to myelin and secondary immune injury in the development of delayed encephalopathy after acute carbon monoxide (CO) poisoning (DEACMP). In order to assess the role of genetic factors in this mechanism, we studied the association between tumor necrosis factor-α308 (TNF-α308) and myelin basic protein (MBP) 5êÂ?Â?-side.. Read More»
- Genet. Mol. Res. 11(4):
- 2012.December.19.1
- DOI:
- 10.4238/2012.December.19.1
Anti-osteoporosis activity of red yeast rice extract on ovariectomy-induced bone loss in rats
Authors: Y.F. Wang, W.T. Liu, C.Y. Chen, H.P. Ke, H.L. Jiang, X.L. Chen, S.Y. Shi, W. Wei and X.N. Zhang
Osteoporosis is the most common bone disease, affecting millions of people worldwide and leading to significant morbidity and high costs. Monacolin K, an extract of red yeast rice (RYR, Hongqu), plays important roles in the management of dyslipidemia, coronary heart disease, and diabetes. Our study aimed to investigate the protective effect of monacolin K.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.27.2
- DOI:
- 10.4238/2015.July.27.2
Two chitin metabolic enzyme genes from Hyriopsis cumingii: cloning, characterization, and potential functions
Authors: G.-L. Wang B. Xu Z.-Y. Bai J.-L. Li
Chitin, the second most important natural polymer in the world, and its N-deacetylated derivative chitosan are found in a wide variety of organisms. These versatile biopolymers are associated with a broad range of biological functions. This article is the first to report the potential functions of 2 chitin metabolic enzyme gen.. Read More»
- Genet. Mol. Res. 11(4):
- 2012.October.15.4
- DOI:
- 10.4238/2012.October.15.4
TGF-�²1 polymorphisms and familial aggregation of liver cancer in Guangxi, China
Authors: P.Q. Wan, J.Z. Wu, L.Y. Huang, J.L. Wu, Y.H. Wei and Q.Y. Ning
The goal of present study was to investigate the relationship between polymorphisms of TGF-β1 and familial aggregation of liver cancer in Guangxi Zhuang, Han, and Yao populations. We conducted a population-based case-control family study of liver cancer in Guanxi, China. A total of 214 individuals from 37 case families were surveyed for polymorphisms.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.27.3
- DOI:
- 10.4238/2015.July.27.3
Genetic diversity of ITS sequences of Bursaphelenchus xylophilus
Authors: J.M.S. Cardoso L. Fonseca I. Abrantes
The sequence variation of internal transcribed spacer (ITS) regions of ribosomal DNA has been routinely used for species identification and species-level phylogeny of the pinewood nematode, Bursaphelenchus xylophilus. In this study, the intraspecies ITS genetic diversity of B. xylophilus was evaluated. Three pinewood nematode isolates from the United Stat.. Read More»
- Genet. Mol. Res. 11(4):
- 2012.October.15.1
- DOI:
- 10.4238/2012.October.15.1