Polymorphisms in the bone morphogenetic protein 15 gene and their effect on sperm quality traits in Chinese Holstein bulls
Authors: L.P. Sun, Y.P. Song, Q.Z. Du, L.W. Song, Y.Z. Tian, S.L. Zhang,G.H. Hua and L.G. Yang
Bone morphogenetic protein 15 (BMP-15) expression has been detected in the testis, but its roles in this organ has not been well elucidated. We evaluated polymorphisms of the BMP-15 gene by PCR-SSCP and PCR-RFLP in 212 Chinese Holstein bulls, and investigated possible associations with sperm quality traits, including semen vol.. Read More»
- Genet. Mol. Res. 13(1):
- http://dx.doi.org/2014.March.17.8
- DOI:
- http://dx.doi.org/10.4238/2014.March.17.8
Interleukin-8 expression associated with canine mammary tumors
Authors: D.A.P.C. Zuccari, R. Castro, G.B. Gelaleti and U.M. Mancini
The use of prognostic markers for mammary cancer is important for routine diagnosis and research. Interleukin-8 (IL-8) is a chemotactic cytokine, produced by several cell types in response to inflammation. The expression, regulation and function of IL-8 in dogs are little known. Recent studies have associated angiogenesis and .. Read More»
- Genet. Mol. Res. 10(3):
- vol10-3gmr1145
- DOI:
- 10.4238/vol10-3gmr1145
Utilization of different methodologies for the characterization of Hb Hasharon heterozygotes
Authors: A.R. Chinelato-Fernandes, C.F. Mendiburu and C.R. Bonini-Domingos
Hb Hasharon has an electrophoretic mobility similar to that of Hb S in cellulose acetate and a mobility between Hb S and C at acid pH. In high-performance liquid chromatography, Hb Hasharon shows a distinct chromatographic profile and retention time. The origin of this variant is a mutation in codon 47 (GAC → CAC) of the .. Read More»
- Genet. Mol. Res. 5(1):
Gene expression profiling: identification of genes with altered expression in Ayu17-449 knockout mice
Authors: Y. Li, T.T. Huang, H. Tang, K.I. Yamamura and X.Y. Pu
Ayu17-449, a novel gene in mice, has been identified as a tumor-suppressor gene in myeloid malignancy; its product catalyzes the conversion of 5-methylcytosine of DNA to 5-hydroxymethylcytosine. However, in vivo, its functional target genes and biological function have remained unclear. Based on the assumption that alterations.. Read More»
- Genet. Mol. Res. 10(3):
- vol10-3gmr1158
- DOI:
- 10.4238/vol10-3gmr1158
Characterization and comparison of transgenic Artemisia annua GYR and wild-type NON-GYR plants in an environmental release trial
Authors: H. Liu, G.G. Wu, J.B. Wang, X. Wu, L. Bai, W. Jiang, B.B. Lv, A.H. Pan, J.W. Jia, P. Li, K. Zhao, L.X. Jiang and X.M. Tang
The anti-malarial drug, artemisinin, is quite expensive as a result of its slow content in Artemisia annua. Recent investigations have suggested that genetic engineering of A. annua is a promising approach to improve the yield of artemisinin. In this study, the transgenic A. annua strain GYR, which has high artemisinin content, was evaluated in an environ.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038273
- DOI:
- 10.4238/gmr.15038273
Comparison of complete mitochondrial DNA control regions among five Asian freshwater turtle species and their phylogenetic relationships
Authors: Y. Jiang, L.W. Nie, Z.F. Huang, W.X. Jing, L. Wang, L. Liu and X.T. Dai
The complete mitochondrial DNA (mtDNA) control regions (CR), cytochrome b (Cyt b), NADH dehydrogenase subunit 4 (ND4) and cytochrome coxidase subunit I (CO I) genes of four Asian freshwater turtles, Mauremys japonica, Ocadia sinensis, M. mutica, and Annamemys annamensis, were sequenced using universal PCR and long-PCR techniqu.. Read More»
- Genet. Mol. Res. 10(3):
A fully resolved consensus between fully resolved phylogenetic trees
Authors: Jos�© Augusto Amgarten Quitzau and Jo�£o Meidanis
Nowadays, there are many phylogeny reconstruction methods, each with advantages and disadvantages. We explored the advantages of each method, putting together the common parts of trees constructed by several methods, by means of a consensus computation. A number of phylogenetic consensus methods are already known. Unfortunatel.. Read More»
- Genet. Mol. Res. 5(1):
Micronuclei as biomarkers for evaluating the risk of malignant transformation in the uterine cervix
Authors: G.M.A. Aires, J.R.C. Meireles, P.C. Oliveira, J.L. Oliveira, E.L. Ara�ºjo, B.C. Pires, E.S.A. Cruz, N.F. Jesus, C.A.B. Pereira and E.M.M. Cerqueira
We evaluated micronucleus and apoptosis occurrence among women with normal smears and women with different kinds of cervical abnormalities, i.e., inflammatory processes and low- and high-grade squamous intraepithelial lesions (N = 12, N = 10 and N = 27, respectively). The sample included 59 women who were seen at a public medi.. Read More»
- Genet. Mol. Res. 10(3):
- vol10-3gmr1156
- DOI:
- 10.4238/vol10-3gmr1156
White mold resistance-associated quantitative trait loci in the Jalo x Small White common bean population
Authors: D.A. Souza, M. Balestre, A.K.A. Pamplona, M.E. Leite, J.A. Dias and J.B. Santos
We aimed to identify simple sequence repeat (SSR) markers linked to quantitative trait loci (QTLs) associated with white mold resistance in a segregating population derived from a cross between common bean cultivars Jalo and Small White, in the Southern State of Minas Gerais. Parents were crossed to obtain the F2 generation of 190 plants. From these, F2:3.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038724
- DOI:
- 10.4238/gmr.15038724
Gene networks as a tool to understand transcriptional regulation
Authors: Diogo Fernando Veiga, F�¡bio Fernandes da Rocha Vicente and Gustavo Bastos
Gene regulatory networks, or simply gene networks (GNs), have shown to be a promising approach that the bioinformatics community has been developing for studying regulatory mechanisms in biological systems. GNs are built from the genome-wide high-throughput gene expression data that are often available from DNA microarray expe.. Read More»
- Genet. Mol. Res. 5(1):