Detecting the potential cancer association or metastasis by multi-omics data analysis
Authors: L. Hua, WY. Zheng, H. Xia and P. Zhou
Comprehensive multi-omics data analyses have become an important means for understanding cancer incidence and progression largely driven by the availability of high-throughput sequencing technologies for genomes, proteomes, and transcriptomes. However, how tumor cells from the site of origin of the cancer begin to grow in other sites of the body is very p.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038987
- DOI:
- 10.4238/gmr.15038987
Epigenetic mechanism of maternal post-traumatic stress disorder in delayed rat offspring development: dysregulation of methylation and gene expression
Authors: X.G. Zhang, H. Zhang, X.L. Liang, Q. Liu, H.Y. Wang, B. Cao, J. Cao, S. Liu, Y.J. Long, W.Y. Xie and D.Z. Peng
Maternal post-traumatic stress disorder (PTSD) increases the risk of adverse neurodevelopmental outcomes in the child. Epigenetic alternations may play an essential role in the negative effects of PTSD. This study was aimed to investigate the possible epigenetic alterations of maternal PTSD, which underpins the developmental and behavioral impact. 24 preg.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15039009
- DOI:
- 10.4238/gmr.15039009
Statistical analyses of conserved features of genomic islands in bacteria
Authors: F.-B. Guo, Z.-K. Xia, W. Wei and H.-L. Zhao
We performed statistical analyses of five conserved features of genomic islands of bacteria. Analyses were made based on 104 known genomic islands, which were identified by comparative methods. Four of these features include sequence size, abnormal G+C content, flanking tRNA gene, and embedded mobility gene, which are frequent.. Read More»
- Genet. Mol. Res. 13(1):
- http://dx.doi.org/2014.March.17.6
- DOI:
- http://dx.doi.org/10.4238/2014.March.17.6
In silico reconstruction of the amino acid metabolic pathways of Trypanosoma cruzi
Authors: A.C.R. Guimar?£es, T.D. Otto, M. Alves-Ferreira, A.B. Miranda and W.M. Degrave
Trypanosoma cruzi is the epidemiological agent of Chagas’ disease, affecting most of Central and South America, constituting a significant health and socio-economic problem. The parasite has a metabolism largely based on the consumption of amino acids, which participate in a diversity of metabolic pathways, leading to ma.. Read More»
- Genet. Mol. Res. 7(3):
- vol7-3x-meeting05
- DOI:
- 10.4238/vol7-3x-meeting05
Defective eyelid leading edge cell migration in C57BL/6-corneal opacity mice with an â??eye open at birthâ? phenotype
Authors: L.C. Wu, C. Liu, M.R. Jiang ,Y.M. Jiang, Q.H. Wang, Z.Y. Lu, S.J. Wang, W.L. Yang and Y.X. Shao
Development of the eyelid requires coordination of the cellular processes involved in proliferation, cell size alteration, migration, and cell death. C57BL/6J-corneal opacity (B6-Co) mice are mutant mice generated by the administration of N-ethyl-N-nitrosourea (100 mg/kg). They exhibit the eyelids open at birth phenotype, abnormal round cell shape from ti.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15036741
- DOI:
- 10.4238/gmr.15036741
Whole exome sequencing implicates PTCH1 and COL17A1 genes in ossification of the posterior longitudinal ligament of the cervical spine in Chinese patients
Authors: W. Wei1, H.-L. He, C.-Y. Chen, Y. Zhao, H.L. Jiang, W.-T. Liu, Z.F. Du, X.-L. Chen, S.Y. Shi, and X.N. Zhang
Ossification of the posterior longitudinal ligament (OPLL) of the cervical spine is a complex multifactorial disease. Patients with OPLL commonly present with symptoms in their 40s or 50s. The genetic basis of OPLL remains poorly understood. Exome capture combined with massively parallel DNA sequencing has been proposed as an .. Read More»
- Genet. Mol. Res. 13(1):
- http://dx.doi.org/2014.March.17.7
- DOI:
- http://dx.doi.org/10.4238/2014.March.17.7
MicroRNA-338-3p inhibits glucocorticoid-induced osteoclast formation through RANKL targeting
Authors: X.H. Zhang, G.L. Geng, B. Su, C.P. Liang, F. Wang and J.C. Bao
The differentiation deficiencies of osteoclast precursors (pre-OCs) may contribute to osteoporosis. Research on osteoporosis has recently focused on microRNAs (miRNAs) that play crucial roles in pre-OC differentiation. In the current study, we aimed to analyze the expression and function of the glucocorticoid (GC)-associated miRNA-338-3p (miR-338-3p) in o.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15037674
- DOI:
- 10.4238/gmr.15037674
ChromaPipe: a pipeline for analysis, quality control and management for a DNA sequencing facility
Authors: T.D. Otto, E.A. Vasconcellos, L.H.F. Gomes, A.S. Moreira,W.M. Degrave, L. Mendon?§a-Lima and M. Alves-Ferreira
Optimizing and monitoring the data flow in high-throughput sequencing facilities is important for data input and output, for tracking the status of results for the users of the facility, and to guarantee a good, high-quality service. In a multi-user system environment with different throughputs, each user wants to access his/h.. Read More»
- Genet. Mol. Res. 7(3):
- vol7-3x-meeting04
- DOI:
- 10.4238/vol7-3x-meeting04
Analysis of the prevalence of polymorphisms in the glutathione S transferase gene (GST) in cataract patients from Goi?¢nia
Authors: I.R. Costa, R.S. Mascarenhas, J.F. Corr?ªa, F.R.B. Oliveira, S.G. Fernandes, F.O. Souza, G.M. dos Reis, A. de P.R. J?ºnior, D.A. Rodrigues, J.V.M. Martins, K.S.F. e Silva and K.K.V.O. Moura
The aim of this study was to determine the prevalence of polymorphisms in the glutathione S-transferase genes GSTM1 and GSTT1 in patients with lens opacity (cataract). Peripheral blood samples were obtained from male and female patients (N = 23) with cataract. The GSTM1 and GSTT1 polymorphic regions were amplified by polymerase chain reaction, and the amp.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038050
- DOI:
- 10.4238/gmr.15038050
Pheno-morphological variation, genetic diversity and population structure of Tunisian Echinus Medic (Medicago ciliaris L.)
Authors: C. Jabri, H. Sbei, N. Zitouna, N. Trifi-Farah and A. Zoghlami Khelil
Medicago ciliaris L., considered as a valuable genetic resource, is a good candidate for the improvement of marginal or degraded lands with low fertility or high salinity. In this study, the pheno-morphological and genetic diversity were investigated in 14 Tunisian populations of M. ciliaris for the first time. Fourteen morphological traits showed signifi.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038595
- DOI:
- 10.4238/gmr.15038595