An algorithm to infer similarity among cell types and organisms by examining the most expressed sequences

Authors: S.A.P. Pinto and J.M. Ortega

Following sequence alignment, clustering algorithms are among the most utilized techniques in gene expression data analysis. Clustering gene expression patterns allows researchers to determine which gene expression patterns are alike and most likely to participate in the same biological process being investigated. Gene express.. Read More»

Genet. Mol. Res. 7(3):

vol7-3x-meeting010

DOI:

10.4238/vol7-3x-meeting010

Genes up- and down-regulated by dermcidin in breast cancer: a microarray analysis

Authors: D.F. Moreira, B.E. Strauss, E. Vannier and J.E. Beliz�¡rio

3-fold change and p 0.005). The gene expression of 208 was reduced and of 27 was increased in the three DCD-RNAi clones compared to pLKO control clone. The expression of 77 genes (37%) encoding for enzymes involved in amino acid metabolism, glucose metabolism and oxidoreductase activity and several genes required for cell surv.. Read More»

Genet. Mol. Res. 7(3):

vol7-3x-meeting009

DOI:

10.4238/vol7-3x-meeting009

Isolation and characterization of microsatellite loci in the fish Coilia mystus (Clupeiformes: Engraulidae) using PCR-based isolation of microsatellite arrays

Authors: J.-Q. Yang, X.-D. Zhou, D. Liu, Z.-Z. Liu and W.-Q. Tang

Coilia mystus is the most important harvested fish species in China; it inhabits quite different water environments during the different life history stages. Populations of C. mystus have dropped sharply due to overharvesting and water pollution. We developed eight microsatellite loci in C. mystus for conservation genetics stu.. Read More»

Genet. Mol. Res. 10(3):

vol10-3gmr1420

DOI:

10.4238/vol10-3gmr1420

A procedure to recruit members to enlarge protein family databases - the building of UECOG (UniRef-Enriched COG Database) as a model

Authors: G.R. Fernandes, D.V.C. Barbosa, F. Prosdocimi, I.A. Pena,L. Santana-Santos, O. Coelho Junior, A. Barbosa-Silva, H.M. Velloso, M.A. Mudado, D.A. Natale, A.C. Faria-Campos, S.V. A. Campos and J.M. Ortega

A procedure to recruit members to enlarge protein family databases is described here. The procedure makes use of UniRef50 clusters produced by UniProt. Current family entries are used to recruit additional members based on the UniRef50 clusters to which they belong. Only those additional UniRef50 members that are not fragments.. Read More»

Genet. Mol. Res. 7(3):

vol7-3x-meeting008

DOI:

10.4238/vol7-3x-meeting008

Boning up on mutations: assessing the significance of candidate disease-causing DNA sequence variation

Authors: R. Dalgleish

Genet. Mol. Res. 10(3):

vol10-3gmr1353

DOI:

10.4238/vol10-3gmr1353

Combined folate gene MTHFD and TC polymorphisms as maternal risk factors for Down syndrome in China

Authors: Y.P. Liao, D. Zhang, W. Zhou, F.M. Meng, M.S. Bao, P. Xiang and C.Q. Liu

We examined whether polymorphisms in the methylenetetrahydrofolate dehydrogenase (MTHFD) and transcobalamin (TC) genes, which are involved in folate metabolism, affect maternal risk for Down syndrome. We investigated 76 Down syndrome mothers and 115 control mothers from Bengbu, China. Genomic DNA was isolated from the peripher.. Read More»

Genet. Mol. Res. 13(1):

http://dx.doi.org/2014.March.17.4

DOI:

http://dx.doi.org/10.4238/2014.March.17.4

A simple and efficient method for predicting protein-protein interaction sites

Authors: R.H. Higa and C.L. Tozzi

Computational methods for predicting protein-protein interaction sites based on structural data are characterized by an accuracy between 70 and 80%. Some experimental studies indicate that only a fraction of the residues, forming clusters in the center of the interaction site, are energetically important for binding. In additi.. Read More»

Genet. Mol. Res. 7(3):

vol7-3x-meeting07

DOI:

10.4238/vol7-3x-meeting07

Higher frequency of CD4+CD25high Treg cells in hemophilia patients with factor VIII inhibitor

Authors: K.Y. Ding, W.C. Ji, J.S. Wu, T. Li and Y.Y. Sheng

The production of factor VIII inhibitor antibodies remains the most costly and serious complication in replacement therapy of hemophilia A. We investigated the clinical significance of CD4+CD25high T regulatory (Treg) cells in hemophilia patients. Our trial included 6 severe hemophilia A patients with factor VIII inhibitors, 6.. Read More»

Genet. Mol. Res. 13(1):

http://dx.doi.org/2014.March.17.5

DOI:

http://dx.doi.org/10.4238/2014.March.17.5

Genetic diversity in natural populations of mangaba in Sergipe, the largest producer State in Brazil

Authors: A.N.R. Soares, M.F. Vit�³ria, A.L.S. Nascimento, A.S. Ledo, A.R.C. Rabbani and A.V.C. Silva

Mangaba (Hancornia speciosa Gomes) is found in areas of coastal tablelands in the Brazilian Northeast and Cerrado regions. This species has been subjected to habitat fragmentation that is mainly due to human activity, and requires conservation strategies. The aim of this study was to analyze the structure and inter- and intrapopulation genetic diversity o.. Read More»

Genet. Mol. Res. 15(3):

gmr.15038624

DOI:

10.4238/gmr.15038624

The full Bayesian significance test for mixture models: results in gene expression clustering

Authors: M.S. Lauretto, C.A.B. Pereira and J.M. Stern

Gene clustering is a useful exploratory technique to group together genes with similar expression levels under distinct cell cycle phases or distinct conditions. It helps the biologist to identify potentially meaningful relationships between genes. In this study, we propose a clustering method based on multivariate normal mixt.. Read More»

Genet. Mol. Res. 7(3):

vol7-3x-meeting06

DOI:

10.4238/vol7-3x-meeting06