Detection of targets and their mechanisms for early diagnosis of traumatic deep vein thrombosis
Authors: J.W. Mo, D-F. Zhang, G.L. Ji, X.-Z. Liu and B. Fan
The purpose of this investigation was to identify targets for the early diagnosis and predictors of deep venous thrombosis (DVT) and the role of these targets in the formation of venous thrombosis. A model of DVT was constructed in rats. Thromboses and venous walls were sampled for reverse transcription polymerase chain reaction study, and blood was sampl.. Read More»
- Genet. Mol. Res. 14(1):
- http://dx.doi.org/2015.March.27.26
- DOI:
- http://dx.doi.org/10.4238/2015.March.27.26
Development and characterization of novel EST-SSR markers and their application for genetic diversity analysis of Jerusalem artichoke (Helianthus tuberosus L.)
Authors: T. Mornkham, P.P. Wangsomnuk, X.C. Mo, F.O. Francisco, L.Z. Gao and H. Kurzweil
Jerusalem artichoke (Helianthus tuberosus L.) is a perennial tuberous plant and a traditional inulin-rich crop in Thailand. It has become the most important source of inulin and has great potential for use in chemical and food industries. In this study, expressed sequence tag (EST)-based simple sequence repeat (SSR) markers we.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048857
- DOI:
- 10.4238/gmr15048857
Pterostilbene as treatment for severe acute pancreatitis
Authors: Y.J. Lin, Y. Ding, J. Wu and B.T. Ning
Acute pancreatitis (AP) has a fast onset and progression, which lead to an unfavorable prognosis. Therefore, the development of novel drugs for its treatment is critical. As a homologous derivative of resveratrol, pterostilbene exerts a variety of effects including anti-inflammatory, antioxidant, and antitumor effects. This study investigated the potentia.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038330
- DOI:
- 10.4238/gmr.15038330
A novel polymorphic Alu insertion embedded in a LINE 1 retrotransposon in the human X chromosome (DXS225): identification and worldwide population study
Authors: Rinaldo Wellerson Pereira, Simone Silva dos Santos and S�©rgio Danilo Junho Pena
We describe a novel polymorphic Alu insertion (DXS225) on the human X chromosome (Xq21.3) embedded into an L1 retrotransposon. The DXS225 polymorphism was genotyped in 684 males from the CEPH Human Genome Diversity Panel. This insertion was found in all regions of the globe, suggesting that it took place before modern humans s.. Read More»
- Genet. Mol. Res. 5(1):
Using the attract method to identify core pathways in juvenile idiopathic arthritis
Authors: J.S. Li, X.L. Gao, Y.R. Liu and Y. Dong
The aim of this study was to identify core pathways associated with juvenile idiopathic arthritis (JIA) using the attract method. Kyoto Encyclopedia of Genes and Genomes pathways were determined using the GSEA-ANOVA method, based on the gene expression data of JIA. Syn-expression groups within core attractor pathways were identified by hierarchical cluste.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038331
- DOI:
- 10.4238/gmr.15038331
Genomic lesions and colorectal carcinogenesis: the effects of protein-calorie restriction and inulin supplementation on deficiency statuses
Authors: W.B. Cantero, N.A. Takahachi, M.O. Mauro, J.R. Pesarini,A.P.M. Rabacow, A.C.M.B. Antoniolli and R.J. Oliveira
The present study investigated the effects of restricting protein and calories and supplementation of inulin, a fiber comprising a linear type of polydisperse carbohydrates composed primarily of fructil-fructose bonds (β-(2→1), on the deficiency statuses of animals in which genomic lesion development and colorectal carcinogenesis had been induce.. Read More»
- Genet. Mol. Res. 14(1):
- http://dx.doi.org/2015.March.27.27
- DOI:
- http://dx.doi.org/10.4238/2015.March.27.27
Micronucleus test on gas station attendants
Authors: Cibelem Iribarrem Benites, LÃ?Âlian Lund Amado, Rita Aloma Packeiser Vianna and Maria da GraÃ?§a Martino-Roth
In the present study, the micronucleus test was applied in exfoliated cells of buccal mucosa to assess the mutagenicity risk associated with occupational exposure for gas station attendants. For each individual, 2000 exfoliated buccal cells were analyzed for micronucleus frequency. A highly significant difference was found bet.. Read More»
- Genet. Mol. Res. 5(1):
The time has come: a new scene for PKU treatment
Authors: Luciana Lara dos Santos, Myrian de Castro Magalh�£es, Jos�© N�©lio Janu�¡rio, Marcos Jos�© Burle de Aguiar and Maria Raquel Santos Carvalho
Phenylketonuria (PKU) is one of the few genetic diseases in which mental retardation can be prevented. Hence, diagnosis and treatment must be established early. PKU treatment consists of a phenylalanine-restricted diet supplemented with a phenylalanine-free mixture of amino acids. However, it is difficult to adhere to this die.. Read More»
- Genet. Mol. Res. 5(1):
Well-balanced commensal microbiota contributes to anti-cancer response in a lung cancer mouse model
Authors: Q.-F. Gui, H.-F. Lu, C.-X. Zhang, Z.-R. Xu and Y.-M. Yang
The intestinal microflora affects inflammation and immunity, not only locally at the mucosal level but also systemically, raising the question of whether the microflora affects inflammatory processes that contribute to cancer and its therapy. Prebiotics have also been found to play an antitumor role that is not limited to the gut. We investigated the anti.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.25.16
- DOI:
- 10.4238/2015.May.25.16
Frequencies of phenylalanine hydroxylase mutations I65T, R252W, R261Q, R261X, IVS10nt11, V388M, R408W, Y414C, and IVS12nt1 in Minas Gerais, Brazil
Authors: Luciana Lara dos Santos, Myrian de Castro Magalh�£es, Adriana de Oliveira Reis, Ana L�ºcia Pimenta Starling, Jos�© N�©lio Janu�¡rio, Cleusa Gra�§a da Fonseca, Marcos Jos�© Burle de Aguiar and Maria Raquel Santos Carvalho
In order to determine the phenylketonuria (PKU) mutation spectrum in the population of Minas Gerais State, Brazil, 78 unrelated PKU patients found by the neonatal screening program from 1993 to 2003 were tested for nine phenylalanine hydroxylase mutations. These mutations were selected due to their high frequencies in other Br.. Read More»
- Genet. Mol. Res. 5(1):