Steroid metabolism gene polymorphisms and their implications on breast and ovarian cancer prognosis
Authors: E.V.W. dos Santos, L.N.R. Alves and I.D. Louro
A role for estrogen in the etiology of breast and ovarian cancers has been suggested; therefore, genetic polymorphisms in steroid metabolism genes could be involved in the carcinogenesis of these tumors. We have aimed to investigate the role of GSTP1 and CYP17 polymorphisms and their correlation with MSI (microsatellite instab.. Read More»
- Genet. Mol. Res. 16(3):
- gmr16039691
- DOI:
- 10.4238/gmr16039691
Genetic variability of a Brazilian Capsicum frutescens germplasm collection using morphological characteristics and SSR markers
Authors: S.I.C. Carvalho, L.B. Bianchetti, C.F. Ragassi, C.S.C. Ribeiro, F.J.B. Reifschneider, G.S.C. Buso and F.G. Faleiro
Characterization studies provide essential information for the conservation and use of germplasm in plant breeding programs. In this study, 103 Capsicum frutescens L. accessions from the Active Germplasm Bank of Embrapa Hortaliças, representative of all five Brazilian geographic regions, were characterized based on morp.. Read More»
- Genet. Mol. Res. 16(3):
- gmr16039689
- DOI:
- 10.4238/gmr16039689
Environmental stratifications for soybean cultivar recommendation and its consistency over time
Authors: R.M. Pacheco, J.B. Duarte, R.G. Branquinho and P.I.D.M. Souza
Stratification of environments is a strategy to capitalize genotype x environment (GxE) interaction, which can optimize the process of assessment and cultivar recommendation, increasing productivity in a target environmental population. The objective of this study was to assess environmental stratification methods based on the.. Read More»
- Genet. Mol. Res. 16(3):
- gmr16039693
- DOI:
- 10.4238/gmr16039693
Mitochondrial DNA control region analysis of three ethnic populations in lower Northern part of Thailand
Authors: U. Suyasunanont, M. Nakkuntod and S. Mirasena
The lower northern part of Thailand contains various genetically diverse ethnic populations. The sequences of the mitochondrial DNA hypervariable region were studied in three ethnic populations inhabiting Phitsanulok Province. One hundred and nine nucleotide sequences - 53, 29, and 27 from Hmongs (Hill tribe), Lao Songs, and T.. Read More»
- Genet. Mol. Res. 16(3):
- gmr16039687
- DOI:
- 10.4238/gmr16039687
Alteration of -656(G/T) and -607(C/A) polymorphisms in interleukin-18 (IL-18) gene in house dust mite-sensitive allergic rhinitis patients in Thailand
Authors: A. Tungtrongchitr, J. Jumpasri, N. Sookrung, N. Visitsunthorn, P. Tantilipikorn, O. Piboonpocanan, N. Indrawattana, R. Tungtrongchitr and W. Chaicumpa
Allergic rhinitis (AR) is an IgE-mediated inflammation of the nasal membranes, which is naturally triggered by aeroallergens. House dust mites (HDM) are the most common inhalant allergens. Interleukin-18 (IL-18) has been established as an essential cytokine that can activate the generation of IgE. This randomized controlled st.. Read More»
- Genet. Mol. Res. 16(3):
- gmr16039641
- DOI:
- 10.4238/gmr16039641
Molecular analysis of the GSTT1 gene polymorphism in patients with clinical manifestation of atherosclerosis
Authors: J.V.M. Martins, D.A. Rodrigues, K.S.F. Silva, I.R. Costa, M.H. Lagares, F.L. Campedelli, A.M. Barbosa, M.P. Morais and K.K.V.O. Moura
Atherosclerosis is a chronic inflammatory disease formed by the accumulation of lipids in the innermost layer and large-caliber artery (tunica intima). This accumulation, along with platelet factors, stimulates the proliferation of muscle cells in this region. Over than 400 genes may be related to the pathology since they regu.. Read More»
- Genet. Mol. Res. 16(3):
- gmr16039620
- DOI:
- 10.4238/gmr16039620
Bayesian analyses of genetic parameters for growth traits in Nellore cattle raised on pasture
Authors: F.B. Lopes, J.L. Ferreira, R.B. Lobo and G.J.M. Rosa
This study was carried out to investigate (co)variance components and genetic parameters for growth traits in beef cattle using a multi-trait model by Bayesian methods. Genetic and residual (co)variances and parameters were estimated for weights at standard ages of 120 (W120), 210 (W210), 365 (W365), and 450 days (W450), and f.. Read More»
- Genet. Mol. Res. 16(3):
- gmr16039606
- DOI:
- 10.4238/gmr16039606
Improvement in orthopedic outcome score and reduction in IL-1�², CXCL13, and TNF-�± in synovial fluid of osteoarthritis patients following arthroscopic knee surgery
Authors: Z.M. Li and M. Li
Knee osteoarthritis (KOA) is a common degenerative joint disease and immune system dysregulation has been implicated in its pathogenesis. The effect of arthroscopic knee surgery, an important method for KOA diagnosis and treatment, on the expression of immune regulators remains poorly understood. We aimed to investigate the cl.. Read More»
- Genet. Mol. Res. 16(3):
- gmr16039487
- DOI:
- 10.4238/gmr16039487
Selection of maize inbred lines and gene expression for resistance to ear rot
Authors: G.S. Pereira, R.G.V. Pinho, E.V.R.V. Pinho, L.P.M. Pires, L.A.Y. Bernardo Junior, J.L.A. Pereira and M.P. Melo
In recent years, there has been a large incidence of fungi causing “ear rot” in maize in Brazil, the main fungus being Fusarium verticillioides. The most efficient and competitive alternative for control of this disease consists of using maize hybrids resistant to this pathogen. Thus, the aims of this study were to.. Read More»
- Genet. Mol. Res. 16(3):
- gmr16039415
- DOI:
- 10.4238/gmr16039415
Clinical significance and expression of PUMA, MCL-1, and p53 in human renal cell carcinoma and para-carcinoma tissues
Authors: H.B. Xia, H.W. Cui, L. Su, Z.H. Zhang, X.Y. Yang, S.Q. Ning and X.L. Su
We investigated the expression level of p53 upregulated modulator of apoptosis (PUMA), myeloid cell leukemia-I (MCL-1), and p53 in renal cell carcinoma (RCC) and para-carcinoma tissues, as well as their clinical significance. The expression levels of PUMA, MCL-1, and p53 in RCC and para-carcinoma tissues were measured using im.. Read More»
- Genet. Mol. Res. 16(3):
- gmr16039278
- DOI:
- 10.4238/gmr16039278