Zhi-Long-Huo-Xue-Tong-Yu modulates mitochondrial fission through the ROCK1 pathway in mitochondrial dysfunction caused by streptozotocin-induced diabetic kidney injury

Authors: W.H. Wu, M.P. Zhang, S.J. Yang, Q. Liu, X. Bai, J.H. Qin,B. Peng, S.T. Ou, J. Liu, C.Y. Zhao, Q. Zhang, Q.D. Hu and L. Xue

Zhi-Long-Huo-Xue-Tong-Yu (ZLHXTY) is a defined mixture of 5 herbs developed by Professor S.J. Yang according to the Buyang Huanwu decoction method, which has been recorded in the Yilingaicuo. This study investigated the renoprotective effects of ZLHXTY on mitochondrial dysfunction induced by diabetic kidney injury in a diabetic rat model. Diabetes was ind.. Read More»

Genet. Mol. Res. 14(2):

2015.May.4.18

DOI:

10.4238/2015.May.4.18

Analysis of the nucleolar cycle in the seminiferous epithelium of rodents

Authors: Peruquetti RL

Genet. Mol. Res. 6(4):

Correlation between polymorphism of platelet alloantigen genes HPA-1-5 and type 2 diabetes complication by carotid atherosclerosis in a Chinese population

Authors: Y.H. Zhang, S.F. Xu, J. Zheng, H.S. Hong and L.M. Fan

We investigated the association between the polymorphism of human platelet alloantigen genes HPA-1-HPA-5 and the complication of type 2 diabetes mellitus (T2DM) by carotid atherosclerosis (CA) among Han people in Guiyang District, China. Ninety-nine T2DM patients were selected from the Affiliated Hospital of Guiyang Medical College and divided into a CA(+.. Read More»

Genet. Mol. Res. 14(2):

2015.May.4.19

DOI:

10.4238/2015.May.4.19

Prediction and biochemical characterization of intrinsic disorder in the structure of proteolysis-inducing factor/dermcidin

Authors: Majczak G, Lilla S, Garay-Malpartida M, Markovic J, Medrano FJ, de Nucci G and Belizario JE

Proteolysis-inducing factor/dermcidin (PIF/DCD) is a novel human gene, located on chromosome 12, locus 12q13.1, that encodes a secreted 110-amino acid protein. Two transcripts for the protein have been identified in normal skin, breast, placenta and brain, and in various primary and metastatic tumor cells. The putative native-.. Read More»

Genet. Mol. Res. 6(4):

Matrix metalloproteinase variants associated with risk and clinical outcome of esophageal cancer

Authors: L. Zhang, R.-X. Xi and X.-Z. Zhang

We conducted a case-control study to investigate the role of matrix metalloproteinase (MMP) 2, MMP3, and MMP9 single nucleotide polymorphisms on susceptibility to esophageal squamous cell carcinoma (ESCC) in a Chinese population, and their association with environmental factors. A total of 226 patients with ESCC, and 226 age- and gender-matched healthy co.. Read More»

Genet. Mol. Res. 14(2):

2015.May.4.20

DOI:

10.4238/2015.May.4.20

Application of latent semantic indexing to evaluate the similarity of sets of sequences without multiple alignments character-by-character

Authors: Couto BRGM, Ladeira AP and Santos MA

Most molecular analyses, including phylogenetic inference, are based on sequence alignments. We present an algorithm that estimates relatedness between biomolecules without the requirement of sequence alignment by using a protein frequency matrix that is reduced by singular value decomposition (SVD), in a latent semanrelattic .. Read More»

Genet. Mol. Res. 6(4):

A simple genetic algorithm for multiple sequence alignment

Authors: Gondro C and Kinghorn BP

Multiple sequence alignment plays an important role in molecular sequence analysis. An alignment is the arrangement of two (pairwise alignment) or more (multiple alignment) sequences of ‘residues’ (nucleotides or amino acids) that maximizes the similarities between them. Algorithmically, the problem consists of ope.. Read More»

Genet. Mol. Res. 6(4):

Analysis and comparison of clinicohematological parameters and molecular and cytogenetic response of two Bcr/Abl fusion transcripts

Authors: S. Polampalli1, A. Choughule2, N. Negi1, S. Shinde2, C. Baisane3, P. Amre3, P.G. Subramanian2, S. Gujral2, K. Prabhash1 and P. Parikh1

Different forms of p210 are produced by alternative splicing, namely b2a2 and b3a2. There have been many contrasting data establishing a relationship between the two Bcr/Abl transcripts and platelet counts and also response to treatment. However, the data published to date have been on a small group of patients. The aim of the present study was to determi.. Read More»

Genet. Mol. Res. 7(4):

vol7-4gmr485

DOI:

10.4238/vol7-4gmr485

Finding protein-protein interaction patterns by contact map matching

Authors: Melo RC, Ribeiro C, Murray CS, Veloso CJM, da Silveira CH, Neshich G, Meira Jr. W, Carceroni RL and Santoro MM

We propose a novel method for defining patterns of contacts present in protein-protein complexes. A new use of the traditional contact maps (more frequently used for representation of the intra-chain contacts) is presented for analysis of inter-chain contacts. Using an algorithm based on image processing techniques, we can com.. Read More»

Genet. Mol. Res. 6(4):

Expression of splice variants of cancer-testis genes ODF3 and ODF4 in the testis of a prostate cancer patient

Authors: S. Ghafouri-Fard M.H. Modarressi

The outer dense fiber (ODF) genes encode proteins that co-assemble along the axoneme of the sperm tail. Recently, it was demonstrated that some ODF genes are aberrantly expressed in tumors, including prostate adenocarcinoma, basal cell carcinoma, and chronic myeloid lymphoma. We cloned ODF3 and ODF4 cDNA from the testis of a patient suffering from prostat.. Read More»

Genet. Mol. Res. 11(4):

2012.October.4.11

DOI:

10.4238/2012.October.4.11