TLR4/NF-�ºB signaling pathway-mediated and oxLDL-induced up-regulation of LOX-1, MCP-1, and VCAM-1 expressions in human umbilical vein endothelial cells..
Authors: Y. Feng, Z.R. Cai, Y. Tang, G. Hu, J. Lu, D. He and S. Wang
This study aimed to investigate the function and signaling pathway of Toll-like receptor 4 (TLR4) in oxidized low-density lipoprotein (oxLDL)-induced up-regulated expressions of oxidized LDL receptor 1 (LOX-1), monocyte chemoattractant protein 1 (MCP-1), and vascular cell adhesion molecule 1 (VCAM-1) in human umbilical vein en.. Read More»
- Genet. Mol. Res. 13(1):
- 2014.January.28.13
- DOI:
- 10.4238/2014.January.28.13
A novel mutation links to von Hippel-Lindau syndrome in a Chinese family with hemangioblastoma
Authors: X.M. Fu, S.L. Zhao, J.C. Gui, Y.Q. Jiang, M.N. Shen, D.L. Su, B.J. Gu,X.Q. Wang, Q.J. Ren, X.D. Yin, W.B. Huang and X.G. Chen
Hemangioblastoma of the central nervous system occurs as sporadic tumors or as a part of von Hippel-Lindau (VHL) disease, an autosomal dominant hereditary tumor syndrome caused by a germline mutation in the VHL tumor suppressor gene. We screened a Chinese family with VHL for mutations in the VHL gene and evaluated a genetic test for diagnosing VHL disease.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.4.9
- DOI:
- 10.4238/2015.May.4.9
Expression of high-mobility group box protein 1 in diabetic foot atherogenesis
Authors: C.F. Tsao, W.T. Huang, T.T. Liu, P.W. Wang, C.W. Liou, T.K. Lin,C.J. Hsieh and S.W. Weng
The role of high mobility group box 1 (HMGB1) has been demonstrated in stroke and coronary artery disease but not in peripheral arterial occlusive disease (PAOD). The pathogenesis of HMGB1 in acute and chronic vascular injury is also not well understood. We hypothesized that HMGB1 induces inflammatory markers in diabetic PAOD patients. We studied 36 diabe.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.4.10
- DOI:
- 10.4238/2015.May.4.10
Cumulative methylation alternations of gene promoters and protein markers for diagnosis of epithelial ovarian cancer
Authors: B.L. Xing, T. Li, Z.H. Tang, L. Jiao, S.M. Ge, X. Qiang and J. OuYang
DNA methylation plays an important role in carcinogenesis and cancer development. In this study, we examined gene methylation in epithelial ovarian cancer (EOC) using cationic conjugated polymer (CCP)-based fluorescence resonance energy transfer (FRET) to evaluate the application of cumulative methylation alternations of genes associated with cancer antig.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.4.11
- DOI:
- 10.4238/2015.May.4.11
Clinicopathological analysis of idiopathic membranous nephropathy in young adults
Authors: Y. Wang, G.P. Wang, B.M. Li and Q.K. Chen
The aim of this study was to understand the clinicopathological features and prognosis of idiopathic membranous nephropathy (IMN) in youth. A retrospective analysis of the clinicopathological features and prognoses of pathologically confirmed IMN in 21 patients aged 15-30 years was performed. IMN was mainly characterized as nephrotic syndrome (NS), with s.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.4.12
- DOI:
- 10.4238/2015.May.4.12
Taxonomic status of Pinus henryi using multiplexed microsatellite markers
Authors: Q. Xie, Z.-H. Liu and Z.-Q. Li
The taxonomic status of Pinus henryi, a rare species endemic to China, is still ambiguous. In this study, the genetic relationships among P. henryi and its congeners (P. tabulaeformis, P. tabulaeformis var. mukdensis, and P. massoniana) were revealed using multiplexed microsatellite markers, including chloroplast microsatellites, nuclear microsatellites, .. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.4.13
- DOI:
- 10.4238/2015.May.4.13
Novel bioinformatic identification of differentially expressed tissue-specific and cancer-related proteins from the Human Protein Atlas for biomarker discovery
Authors: X.-X. Liu and F.-J. Liu
Identification of cancer-associated and tissue-specific proteins is important for research on carcinogenesis mechanisms and biomarker discovery. Here we performed a new strategy to identify candidate cancer proteins by mining immunohistochemistry protein profiles. Proteins with quantitative values from 14 normal tissues and their corresponding cancer tiss.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.4.14
- DOI:
- 10.4238/2015.May.4.14
Phylogeographic analysis of African swine fever virus based on the p72 gene sequence
Authors: Y. Muangkram, M. Sukmak and W. Wajjwalku
African swine fever virus (ASFV) outbreak has been considered as an emerging and re-emerging disease for almost a century. Diagnostically, simple polymerase chain reaction and sequencing-based molecular detection could be employed for both viral identification and genotyping. This study established a novel phylogenetic analysis and epidemiology comparison.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.4.15
- DOI:
- 10.4238/2015.May.4.15
Molecular cloning and expression analysis of GhLOF genes in upland cotton (Gossypium hirsutum L.)
Authors: T.C. Dai and Z.M. Wang
Shoot branching, i.e., the timing and position of shoot growth, determines to a large extend the pattern of plant architecture, and is the result of the integration of a plant’s genetic background and environmental cues. Many genes that are involved in the formation and outgrowth of axillary buds have been cloned, but the exact mechanism is still un.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.4.16
- DOI:
- 10.4238/2015.May.4.16
Association between the rs189037 single nucleotide polymorphism in the ATM gene promoter and cognitive impairment
Authors: X. Ding, J.R. Yue, M. Yang, Q.K. Hao, H.Y. Xiao, T. Chen, L.Y. Gao and B.R. Dong
The aim of this study was to explore the existence of a relationship between the rs189037 single nucleotide polymorphism (SNP) of the ataxia telangiectasia mutated (ATM) gene and cognitive impairment in the elderly (aged 60 years and above). In a cohort, 505 residents of Suinung City were consecutively recruited and their cognitive function was measured u.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.4.17
- DOI:
- 10.4238/2015.May.4.17